A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels. The findings, published in Nature Communications, may improve current strategies to improve blood flow in ischemic tissue, such as that found in atherosclerosis and peripheral vascular disease associated with diabetes.
“Our research shows that the formation of fully functional blood vessels requires activation of protein kinase Akt by a protein called R-Ras, and this mechanism is necessary for the formation of the hallow structure, or lumen, of a blood vessel.” says Masanobu Komatsu, Ph.D., associate professor at SBP’s Lake Nona campus. “The findings are important because they shed new light on the biological process needed to increase blood flow in ischemic tissues.”
Previous efforts to treat ischemia by creating new blood vessels have focused on delivering angiogenic growth factors like vascular endothelial growth factor (VEGF) to ischemic sites. But all of these studies, including more than 25 phase II and III clinical trials, have failed to offer significant benefit to patients.
Komatsu’s research team used a combination of 3D cell culture and living tissue to show that VEGF promotes vascularization, but the vessel structures formed are chaotic, unstable and non-functional. “Functional vessels need to have a lumen; a pipe-like opening that allows oxygenated blood and nutrients to travel through the body,” explains Komatsu, “and VEGF alone cannot fully support the formation of such a vessel structure.”
“Generating new blood vessels is similar to the way trees grow; sprouts develop from existing vessels and then branch out further and further to restore vascularity, says Fangfei Li, Ph.D., postdoctoral associate in Komatsu’s lab and lead author of the paper. “This study shows that there are distinct steps and signals that control the process.
“First, VEGF activates Akt to induce endothelial cells to sprout. Then, R-Ras activates Akt to induce lumen formation,” explains Li. “The second step involving Akt activation by R-Ras stabilizes the microtubule cytoskeleton in endothelial cells, creating a steady architecture that promotes lumen formation,” explains Li.
“We propose that VEGF and R-Ras activation of Akt signaling are complementary to each other, both are necessary to generate fully functional blood vessels to repair ischemic tissue,” says Komatsu. “Our next step is to work toward promoting the combined signaling of Akt in clinical studies; prompting R-Ras activation through either gene therapy or pharmacologically in parallel with VEGF therapy,” says Komatsu.
The Latest on: New blood vessels
[google_news title=”” keyword=”new blood vessels” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
- Why Episodes of Low Blood Sugar Worsen Eye Disease in People With Diabeteson January 26, 2023 at 4:40 pm
People with diabetes who experience low blood sugar are more likely to experience worsening diabetic retinopathy.
- New exhibit showcases Mexico's endangered salamanderon January 26, 2023 at 4:16 pm
STORY: This is Mexico’s legendary axolotl salamander an amphibian with the ability to heal itselfThe critically endangered animal is the focusof a new museum and conservation centerat Mexico City’s ...
- Researchers unravel why episodes of low blood sugar worsen eye disease in people with diabeteson January 26, 2023 at 11:11 am
People with diabetes who experience periods of low blood sugar—a common occurrence in those new to blood sugar management—are more likely to have worsening diabetic eye disease. Now, researchers at ...
- Why gene variant impairing alcohol breakdown raises heart disease riskon January 25, 2023 at 6:11 pm
All these effects were exacerbated by exposing cells to alcohol. The gene variant also impairs the growth of new blood vessels. “That means that when there is a heart attack, when there is a ...
- New Study Shows 4 Categories of Long COVID Symptoms To Watch Out for—Do These Signs Sound Familiar?on January 24, 2023 at 4:15 pm
While long COVID affects everyone differently, there is a new study that reveals four major types of symptoms. Researchers found symptoms fall under the following categories: Interestingly, results ...
- New Approaches To Macular Degeneration: Test Tube Retinason January 24, 2023 at 5:40 am
Researchers have developed a new model of the retina to study one of the leading causes of blindness: age-related macular degeneration.
- New tool uses ultrasound 'tornado' to break down blood clotson January 23, 2023 at 12:57 pm
"The fact that our new technique works quickly is important, because CVST clots increase pressure on blood vessels in the brain," says Chengzhi Shi, co-corresponding author of the work and an ...
- Moderna Begins Administering New MRNA Shot That Is Injected Directly Into the Hearton January 23, 2023 at 7:25 am
Moderna is currently developing an mRNA shot that aims to help the body produce relaxin, a hormone that can increase blood flow and potentially reduce the risk of a heart attack. Using the same ...
- Artificial Blood Vessels Market (New Forecast Report) 2023-2029 With Rising Demand and Growth, Competitors strategicson January 19, 2023 at 9:23 am
TOP MANUFACTURERS Listed in The Artificial Blood Vessels Market Report Are: Global Artificial Blood Vessels Market Report 2023 is spread across 115 pages and provides exclusive vital statistics, data, ...
- Males with obesity may be more at risk of heart complications, but why?on January 16, 2023 at 4:00 pm
Share on Pinterest Recent animal research delves into the mechanisms underlying the higher risk of heart problems in males with obesity. Image credit: Lilith Matevosyan/Stocksy. Women show ...
via Google News and Bing News