A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels. The findings, published in Nature Communications, may improve current strategies to improve blood flow in ischemic tissue, such as that found in atherosclerosis and peripheral vascular disease associated with diabetes.
“Our research shows that the formation of fully functional blood vessels requires activation of protein kinase Akt by a protein called R-Ras, and this mechanism is necessary for the formation of the hallow structure, or lumen, of a blood vessel.” says Masanobu Komatsu, Ph.D., associate professor at SBP’s Lake Nona campus. “The findings are important because they shed new light on the biological process needed to increase blood flow in ischemic tissues.”
Previous efforts to treat ischemia by creating new blood vessels have focused on delivering angiogenic growth factors like vascular endothelial growth factor (VEGF) to ischemic sites. But all of these studies, including more than 25 phase II and III clinical trials, have failed to offer significant benefit to patients.
Komatsu’s research team used a combination of 3D cell culture and living tissue to show that VEGF promotes vascularization, but the vessel structures formed are chaotic, unstable and non-functional. “Functional vessels need to have a lumen; a pipe-like opening that allows oxygenated blood and nutrients to travel through the body,” explains Komatsu, “and VEGF alone cannot fully support the formation of such a vessel structure.”
“Generating new blood vessels is similar to the way trees grow; sprouts develop from existing vessels and then branch out further and further to restore vascularity, says Fangfei Li, Ph.D., postdoctoral associate in Komatsu’s lab and lead author of the paper. “This study shows that there are distinct steps and signals that control the process.
“First, VEGF activates Akt to induce endothelial cells to sprout. Then, R-Ras activates Akt to induce lumen formation,” explains Li. “The second step involving Akt activation by R-Ras stabilizes the microtubule cytoskeleton in endothelial cells, creating a steady architecture that promotes lumen formation,” explains Li.
“We propose that VEGF and R-Ras activation of Akt signaling are complementary to each other, both are necessary to generate fully functional blood vessels to repair ischemic tissue,” says Komatsu. “Our next step is to work toward promoting the combined signaling of Akt in clinical studies; prompting R-Ras activation through either gene therapy or pharmacologically in parallel with VEGF therapy,” says Komatsu.
The Latest on: New blood vessels
[google_news title=”” keyword=”new blood vessels” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
- MUSC touts new medical device as life-saving treatment for aneurysms, tears in main arteryon November 20, 2022 at 8:00 am
Officials at The Medical University of South Carolina said the hospital is the first in the Southeast region to use the Thoraflex Hybrid frozen elephant trunk device to treat complex ...
- Researchers Just Found a Surprising New Treatment for Erectile Dysfunctionon November 20, 2022 at 5:04 am
Sometimes a problem with your sex life is linked with another health-related issue. For example, erectile dysfunction (ED) can result from blood pressure problems, taking certain medications, and ...
- Study reveals a new approach for Alzheimer's therapieson November 20, 2022 at 4:34 am
We were able to demonstrate that medin considerably increases the pathological changes in the blood vessels of Alzheimer's patients " explained Dr Jonas Neher, the study's principal investigator and ...
- Major Implications – Scientists Have Created a “Living Blood Vessel”on November 19, 2022 at 6:10 pm
This is the first time scientists have observed vessels form with such a close resemblance to the complicated structure of naturally occurring blood vessels. An international research collaboration he ...
- Study Reveals How Growing Motor Neurons Guide Blood Vessel Growthon November 18, 2022 at 7:40 am
Researchers have discovered how motor neurons direct blood vessel growth around them while growing toward target muscles.
- New target for Alzheimer's therapies foundon November 17, 2022 at 10:02 am
Of these proteins, amyloid-β is best known because it clumps together in the brains of Alzheimer's patients. These aggregates then deposit both as so-called plaques directly in the brain tissue, but ...
- 4 Crucial Questions to Ask Before Taking Blood Pressure Medication, According to a Pharmaciston November 17, 2022 at 4:03 am
You probably already know that blood pressure medications can keep your blood pressure at a healthy level—but do you know how they do that? The Centers for Disease Control and Prevention (CDC) ...
- Meditation practice done by millions can rapidly lower your blood pressure - new studyon November 17, 2022 at 12:26 am
Systolic blood pressure is the top number in a blood pressure reading and reflects the amount of pressure in your blood vessels during a heartbeat. It was a decrease that was four ...
- Scientists develop new injectable hydrogel for treatment of aneurysmson November 16, 2022 at 9:10 am
Aneurysms, abnormal enlargement or ballooning in the wall of blood vessels can result in rupture and fatal bleeding ... Terasaki Institute for Biomedical Innovation (TIBI), developed a new injectable ...
- Team applies fiber optics instead of lenses to open a new horizon of super-resolution photoacoustic microscopeson November 16, 2022 at 6:18 am
Newly developed photoacoustic microscopy uses vibrations generated when light is absorbed and captures images of cells or blood vessels. This development has ... Recently, a POSTECH research team has ...
via Google News and Bing News