A new drug being trialled for treating breast cancer and diabetes has been shown to ‘melt away’ the fat inside arteries that can cause heart attacks and strokes.
Researchers from the University of Aberdeen, using pre-clinical mouse models, showed that just a single dose of the drug (Trodusquemine) completely reversed the effects of a disease that causes a host of heart problems.
Atherosclerosis is the build-up of fatty material inside the arteries.
Over time this fatty material can grow bigger until your arteries become so narrow that not enough blood can pass through.
Atherosclerosis is the condition that causes most heart attacks and strokes.
In pre-clinical tests, mice with set-in atherosclerosis, mimicking what happens in humans, had less fatty plaques in their arteries whether they had regular doses over time or just a single dose of Trodusquemine.
The drug works by stopping an enzyme called PTP1B, which is normally increased in people with obesity or diabetes and conditions involving prolonged inflammation such as sepsis, inflamed diabetic foot ulcers and allergic lung inflammation. The researchers found that it also stimulated the action of another protein (AMPK), which effectively mimics exercise and reduces chronic inflammation.
It has already been shown to be effective with diabetes and breast cancer patients but this is the first time the drug has been shown to have benefits for long-term cardiovascular disease.
The £236,000 study was funded by the British Heart Foundation.
Professor Mirela Delibegovic and Dr Dawn Thompson from the University of Aberdeen’s Institute of Medical Sciences who led the study said: “All humans have some level of atherosclerosis. As you age you start to develop these fatty streaks inside your arteries. It is a big problem for people who are overweight or have underlying cardiovascular conditions.”
“Trodusquemine has already been trialled for treatment of diabetes and breast cancer but this is the first time it has been used in models of atherosclerosis.
“These have only been tested at pre-clinical level, in mice, so far but the results were quite impressive and showed that just a single dose of this drug seemed to completely reverse the effects of arthrosclerosis.
“The next step is to test the ability of this drug to improve outcomes in human patients with developed atherosclerosis and cardiovascular disease”.
Learn more: Drug ‘melts away’ fat inside arteries
The Latest on: Atherosclerosis
- Global Atherosclerosis Drugs Market 2021: Research Report: Size, Share, Growth, Trends and Forecast 2025on January 18, 2021 at 11:55 pm
Global “Atherosclerosis Drugs market” competitive landscape provides particulars and data information by players.
- Why Are My Feet Always Cold When My Body Is Warm? 5 Surprising Reasonson January 18, 2021 at 12:41 am
Having cold feet when your body is warm might be your body's way of telling you to watch out for a more serious condition.
- Is Heart Disease Genetic?on January 15, 2021 at 11:54 am
Your blue eyes, your brown hair, and, yes, your heart health can be passed down through the generations. Here's what to know about risk, treatments, and more. The post Is Heart Disease Genetic?
- Cannabis Use Not Associated With Hardening Of The Arterieson January 15, 2021 at 9:23 am
Hardening of arteries happens when fat and cholesterol (and other substances) build upon the walls of people’s arteries. It’s most common in the heart, but can occur elsewhere. The deposits, commonly ...
- High cholesterol can lead to deadly atherosclerosis - can the condition be reversed?on January 14, 2021 at 7:14 am
HIGH cholesterol refers to too much of the fatty substance in the bloodstream; it can clump together and settle on the artery walls. This narrowing of the arteries may lead to life-threatening health ...
- Reflections on the Pathologic Physiology of Atherosclerosison January 13, 2021 at 4:00 pm
Serum Lipids and AtherogenesisWith this necessarily sketchy discussion of lipid physiology as a background, it is appropriate to consider what the relation of the serum lipids and atherosclerosis ...
- Senescent intimal foam cells are deleterious at all stages of atherosclerosison January 5, 2021 at 4:00 pm
Studying mouse models, Childs et al. examined the role of senescent lipid-loaded macrophages (so-called “foam cells”) in the pathogenesis of atherosclerosis. At early stages of atherosclerosis, ...
- Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activationon January 1, 2021 at 4:00 pm
See allHide authors and affiliations Although fatty foods often have a bad reputation when it comes to atherosclerosis, a study by Çimen et al. identifies a type of fat that is not only harmless but ...
- A New 3D Imaging Method for Atherosclerosis Analysis in Miceon December 22, 2020 at 11:52 am
Atherosclerosis is the build-up of fatty plaques in blood vessels that, when ruptured, can cause thrombosis (aka a blood clot). The workflow described in this study would be able to obtain 3D images ...
- Protecting against atherosclerosis at the molecular levelon December 19, 2020 at 4:00 pm
Tsukuba, Japan - Atherosclerosis is the result of a buildup of lipids in the inner walls of blood vessels, and is a major cause of heart disease and stroke. In a new study, researchers from the ...
via Google News and Bing News