Scientists have found a way of mimicking our body’s natural healing process, using cell derived nano-sized particles called vesicles, to repair damaged tissue.
The paper, published in Scientific Reports, describes a new approach to bone regeneration; stimulating cells to produce vesicles which can then be delivered to facilitate tissue regeneration.
The research team, led by the University of Birmingham, believe that the findings mark the first step in a new direction for tissue regeneration with the potential to help repair bone, teeth and cartilage.
Fracture numbers are expected to double by 2020, putting tremendous strain on healthcare-systems worldwide. Osteoporosis-fragility fractures alone represent a cost of £1.5 billion to the NHS, and for individuals it can have a detrimental impact on quality of life.
Current approaches have significant limitations; autologous grafts cannot meet demand and cause patient morbidity, allogeneic bone lacks bioactive factors, and growth factor-based approaches (e.g. BMP-2) may have serious side-effects and high costs.
Consequently, there is a considerable need to devise new methods for the generation of large volumes of bone without associated patient morbidity.
In recent years, attention has been focused on cell-based approaches. However, translation is frequently prevented by insurmountable regulatory, ethical and economic issues.
This novel solution delivers all the advantages of cell-based therapies but without using viable cells, by harnessing the regenerative capacity of nano-sized particles called extracellular vesicles that are naturally generated during bone formation.
Excitingly, the team have shown in-vitro that if extracellular vesicles are applied in combination with a simple phosphate the therapy outperforms the current gold standard, BMP-2.
Dr Sophie Cox, from the School of Chemical Engineering at the University of Birmingham, explained, “Though we can never fully mimic the complexity of vesicles produced by cells in nature, this work describes a new pathway harnessing natural developmental processes to facilitate hard tissue repair.”
Dr Owen Davies, EPSRC E-TERM Landscape Fellow at the University of Birmingham and Loughborough University, added, “It is early days, but the potential is there for this to transform the way we approach tissue repair. We’re now looking to produce these therapeutically valuable particles at scale and also examine their capacity to regenerate other tissues.”
The team includes researchers from the University of Loughborough and University College Dublin, and was funded by an EPSRC E-TERM Landscape Fellowship (Dr Davies), MRC Confidence in Concept grant (Dr Davies and Dr Cox) and the School of Chemical Engineering at the University of Birmingham.
The Latest on: Tissue regeneration
[google_news title=”” keyword=”tissue regeneration” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
- Researchers discover how rapid tendon regeneration occurs in newtson November 28, 2023 at 6:55 pm
A research group led by Nagoya University's Graduate School of Engineering has uncovered how rapid tendon regeneration occurs in newts.
- Reprogramming tissue mechanically to promote wound healingon November 28, 2023 at 7:43 am
Researchers at PSI and ETH Zurich have taken connective tissue cells that have been mechanically reprogrammed to resemble stem cells and transplanted them into damaged skin. In their laboratory ...
- Cell fate choice during adult regeneration is highly disorganized, study findson November 28, 2023 at 7:31 am
A team of scientists at the Whitehead Institute for Biomedical Research and MIT has spatially mapped the choices stem cells make during tissue regeneration in flatworms, revealing an unexpected ...
- Reprogramming tissue mechanicallyon November 28, 2023 at 1:12 am
Villigen, 28.11.2023 - Researchers at PSI and ETH Zurich have taken connective tissue cells that have been mechanically reprogrammed to resemble stem cells and transplanted them into damaged skin. In ...
- Review shows benefits of regenerative medicine for joint issues in horseson November 23, 2023 at 12:51 pm
Regenerative therapies involve the use of living cells and non-cell therapies to treat various diseases, injuries, and medical conditions to restore affected tissue to its native state.
- Vitamin B12 could boost tissue repair, help treat ulcerative colitison November 23, 2023 at 9:01 am
Research using mouse models of ulcerative colitis suggests that vitamin B12 can accelerate tissue regeneration, potentially helping treat this form of IBD, among other uses.
- This biomaterial can regenerate bone tissueon November 22, 2023 at 3:30 pm
Researchers have created a unique biomaterial that can regenerate bone tissue in order to improve a variety of treatments, including bone grafts and dental implants.
- Satellos Bioscience Announces 2023 Q3 Financial Results and Operational Highlightson November 22, 2023 at 4:00 am
Satellos appointed Michael Cross, PhD, MBA, as Chief Business Officer and other key leadership team members including Chief Financial Officer and Senior Vice President, Clinic ...
- Pamela and Paul Austin Chair in Precision and Regenerative Medicine will accelerate breakthroughson November 17, 2023 at 8:03 am
New research chair at U of T Engineering made possible by a $2.5-million donation from The P. Austin Family Foundation ...
- Vitamin B12: A key player in cellular reprogramming and tissue regenerationon November 16, 2023 at 8:25 pm
Researchers reveal that vitamin B12 significantly boosts the efficiency of cellular reprogramming, thus holding promise for regenerative medicine. Vitamin B12 supplementation shows potential in ...
via Google News and Bing News