Sleep deprivation – typically administered in controlled, inpatient settings – rapidly reduces symptoms of depression in roughly half of depression patients, according the first meta-analysis on the subject in nearly 30 years, from researchers at the Perelman School of Medicine at the University of Pennsylvania.
Partial sleep deprivation (sleep for three to four hours followed by forced wakefulness for 20-21 hours) was equally as effective as total sleep deprivation (being deprived of sleep for 36 hours), and medication did not appear to significantly influence these results. The results are published today in the Journal of Clinical Psychiatry.
Although total sleep deprivation or partial sleep deprivation can produce clinical improvement in depression symptoms within 24 hours, antidepressants are the most common treatment for depression. Such drugs typically take weeks or longer to experience results, yet 16.7 percent of 242 million U.S. adults filled one or more prescriptions for psychiatric drugs in 2013. The findings of this meta-analysis hope to provide relief for the estimated 16.1 million adults who experienced a major depressive episode in 2014.
Previous studies have shown rapid antidepressant effects from sleep deprivation for roughly 40-60 percent of individuals, yet this response rate has not been analyzed to obtain a more precise percentage since 1990 despite more than 75 studies since then on the subject.
“More than 30 years since the discovery of the antidepressant effects of sleep deprivation, we still do not have an effective grasp on precisely how effective the treatment is and how to achieve the best clinical results,” said study senior author Philip Gehrman, PhD, an associate professor of Psychiatry and member of the Penn Sleep Center, who also treats patients at the Cpl. Michael J. Crescenz VA Medical Center. “Our analysis precisely reports how effective sleep deprivation is and in which populations it should be administered.”
Reviewing more than 2,000 studies, the team pulled data from a final group of 66 studies executed over a 36 year period to determine how response may be affected by the type and timing of sleep deprivation performed (total vs early or late partial sleep deprivation), the clinical sample (having depressive or manic episodes, or a combination of both), medication status, and age and gender of the sample. They also explored how response to sleep deprivation may differ across studies according to how “response” is defined in each study.
“These studies in our analysis show that sleep deprivation is effective for many populations,” said lead author Elaine Boland, PhD, a clinical associate and research psychologist at the Cpl. Michael J. Crescenz VA Medical Center. “Regardless of how the response was quantified, how the sleep deprivation was delivered, or the type of depression the subject was experiencing, we found a nearly equivalent response rate.”
The Latest on: Depression
- This top-rated therapy light used to treat seasonal depression is on sale at Nordstrom Rack for 30% offon January 19, 2022 at 3:46 pm
If you’ve been feeling the effects of seasonal affective disorder (SAD) — colloquially known as the “winter blues” — it might be time to invest in a therapy lamp. While these can sometimes run you up ...
- Jamie Chung had twins via surrogate, so why did she have postpartum depression?on January 19, 2022 at 1:06 pm
Actor Jamie Chung, who welcomed twin boys via surrogate, is opening up about her experience with postpartum depression. “I was so resentful, and I had anxiety ...
- Advanced AIs Exhibiting Depression and Addiction, Scientists Sayon January 19, 2022 at 12:37 pm
A new preprint study out of the Chinese Academy of Science (CAS) claims that many big name chatbots, when asked the types of questions generally used as cursory intake queries for depression and ...
- Fierce JPM Week: Sage wants to 'raise the bar' on depression meds with quick start zuranoloneon January 19, 2022 at 12:30 pm
Existing meds haven't delivered on treating the depression that impacts millions of Americans. That's how Sage Therapeutics sees it, and with partner Biogen, the biopharma thinks it can "raise the bar ...
- Two-Thirds Of Physicians Say Psilocybin Therapy Can Help Treatment-Resistant Depression, New Survey Showson January 19, 2022 at 10:35 am
Psilocybin-focused mental health care company COMPASS Pathways plc (NASDAQ: CMPS) and Sermo announced on Wednesday findings from a survey of Sermo physician members that showed two-thirds of doctors s ...
- My Students, Their Familes, The Lockdowns and Depressionon January 19, 2022 at 9:50 am
Bouts of depression are a normal, even inevitable, part of life. Anyone who tries to tell you otherwise is either deluded, dishonest or hasn't actually experienced the full emotional panorama of human ...
- Feelings of depression and anxiety ‘increased sharply over Christmas’on January 19, 2022 at 6:16 am
A survey found that, despite there being fewer Covid restrictions, symptoms were on a par with levels during lockdown at the start of 2021.
- Depression, anxiety symptoms linked to changes in biological rhythms and nighttime activity in new mothers: studyon January 19, 2022 at 6:11 am
TORONTO-- Any new mother can tell you that sleep is an important factor in how they feel, but a new study has found that certain changes in sleep and in ...
- Duchess of Cambridge's brother on former depression: 'Some of us are just surviving'on January 19, 2022 at 5:42 am
The mental health advocate shared his thoughts on January, goal setting, and how he's approached the month – in a way that's best for his mental health.
- Postnatal depression in dads: The science underlining this overlooked conditionon January 18, 2022 at 7:00 pm
Nearly one in four new fathers suffer from anxiety and depression in the first year following their children's birth. Should we be doing more to help them?
via Google News and Bing News