Self-destroyed redox-sensitive stomatocyte nanomotor delivers and releases drugs for cells
Autonomous targeting and release of drugs at their site of action are desired features of nanomedical systems. Now, a team of Dutch scientists has designed a nanomotor that has these functions: An antitumor drug encapsulated in self-propelled, self-assembled stomatocytes is carried across the cellular membrane and released inside the cell upon a chemical redox signal that disassembles the vesicle membrane. This deliver and unpack nanomedicinal system is introduced in the journal Angewandte Chemie.
Self-propelling nanovesicles are attractive transport vehicles for drugs. If they are fueled by hydrogen peroxide, these vesicles can take up directed motion responding to its concentration gradient. Combining the ideas of self-propelling nanomotors, drug encapsulation, and triggered destruction of the nanocarrier, Daniela A. Wilson and her team at Radboud University, The Netherlands, have designed an artificial self-propelling vesicle, which is sealed by a block copolymer shell and opens to release the loaded drug load if it encounters higher concentrations of glutathione, a chemical signal inside cells.
Glutathione is a so-called redox molecule, an antioxidant. In the cell, this small peptide acts as a scavenger of reactive oxygen species; besides, it serves as a pool for the amino acid cysteine. Elevated levels of glutathione are frequently found inside tumor cells. Wilson and her team came upon glutathione in their attempt to find a door-opener for their drug-loaded, self-propelling artificial vesicles: “The small glutathione can enter into the PEG shell of the nanomotor and then break down the redox-responsive disulfide bonds […], resulting in cleavage of the outside PEG shell,” they wrote. Thus, upon cleaving disulfide bonds, glutathione triggers the vesicle membrane disassembly, and the content of the vesicle, which can be a drug, is distributed in the target cell.
The material of the vesicle membrane is a block copolymer made of poly(ethylene glycol) (PEG) and polystyrene, both of which are connected by a disulfide bond. During self-assembly, a hydrophilic anticancer drug can be encapsulated. Then, the artificial vesicle is transformed into a bowl-shaped stomatocyte, a vesicle with a special dent or groove, by adding the engine, platinum nanoparticles. This nanoparticle catalyst degrades hydrogen peroxide, which is typically produced by tumor cells, propelling the stomatocytes forward, for example, across the cell membrane. There, glutathione, as it were, presses the door handle, opens the vesicle, and stops the motion by catalyst poisoning.
For human cell cultures, the authors demonstrated internalization of the stomatocyte nanomotors, their degradation, and drug release. They propose the nano-submarine as an attractive concept for future drug delivery applications.
Learn more: Nanosubmarine with Self-Destroying Activity
The Latest on: Nanomedical systems
- Review Highlights Potential of Nanotherapies In Diagnosing, Treating Rare CNS Diseaseson February 26, 2021 at 7:02 am
Current delivery systems and diagnostic tools ... An additional limitation to the development of nanomedical approaches is a lack of information on cellular and tissue interactions of the nanocarriers ...
- Nanomedical Market Size, Share, Growth, Sales and Drivers Analysis Research Report 2027on February 18, 2021 at 9:36 am
Market Research Engine is a global market research and consulting organization. We provide market intelligence in emerging, niche technologies and markets. Our market analysis powered by rigorous ...
- NanoMedical Tackles Opioid Abuse with Combination Deviceon February 10, 2021 at 4:00 pm
NanoMedical Systems has received a nearly $3 million grant from the Department of Defense to develop a combination device for the long-term treatment of opioid use. The grant provides $2,993,398 over ...
- Fully Synthetic Bioengineered Nanomedical Scaffold in Chronic Neuropathic Foot Ulcerson October 12, 2018 at 11:00 am
The nanomedical scaffold was rehydrated in room temperature saline ... Affiliation: Southern Arizona VA Health Care System, Tucson, AZ Correspondence: Jodi L. Walters, DPM, Podiatrist and Director of ...
- Implantable Nanomedical Scaffold Facilitates Healing of Chronic Lower Extremity Woundson September 20, 2018 at 4:12 pm
and Provant Therapy Systems (Regenesis Biomedical Inc, Scottsdale, AZ). The wound was treated with the implantable nanomedical scaffold and healed in 4 weeks with 3 applications. Case 2 (Figure 1F-1J) ...
via Google News and Bing News