DNA, the stuff of life, may very well also pack quite the jolt for engineers trying to advance the development of tiny, low-cost electronic devices.
Much like flipping your light switch at home—only on a scale 1,000 times smaller than a human hair—an ASU-led team has now developed the first controllable DNA switch to regulate the flow of electricity within a single, atomic-sized molecule. The new study, led by ASU Biodesign Institute researcher Nongjian Tao, was published in the advanced online journal Nature Communications ( DOI: 10.1038/ncomms14471).
“It has been established that charge transport is possible in DNA, but for a useful device, one wants to be able to turn the charge transport on and off. We achieved this goal by chemically modifying DNA,” said Tao, who directs the Biodesign Center for Bioelectronics and Biosensors and is a professor in the Fulton Schools of Engineering. “Not only that, but we can also adapt the modified DNA as a probe to measure reactions at the single-molecule level. This provides a unique way for studying important reactions implicated in disease, or photosynthesis reactions for novel renewable energy applications.”
Engineers often think of electricity like water, and the research team’s new DNA switch acts to control the flow of electrons on and off, just like water coming out of a faucet.
Previously, Tao’s research group had made several discoveries to understand and manipulate DNA to more finely tune the flow of electricity through it. They found they could make DNA behave in different ways — and could cajole electrons to flow like waves according to quantum mechanics, or “hop” like rabbits in the way electricity in a copper wire works –creating an exciting new avenue for DNA-based, nano-electronic applications.
Tao assembled a multidisciplinary team for the project, including ASU postdoctoral student Limin Xiang and Li Yueqi performing bench experiments, Julio Palma working on the theoretical framework, with further help and oversight from collaborators Vladimiro Mujica (ASU) and Mark Ratner (Northwestern University).
To accomplish their engineering feat, Tao’s group, modified just one of DNA’s iconic double helix chemical letters, abbreviated as A, C, T or G, with another chemical group, called anthraquinone (Aq). Anthraquinone is a three-ringed carbon structure that can be inserted in between DNA base pairs but contains what chemists call a redox group (short for reduction, or gaining electrons or oxidation, losing electrons).
These chemical groups are also the foundation for how our bodies’ convert chemical energy through switches that send all of the electrical pulses in our brains, our hearts and communicate signals within every cell that may be implicated in the most prevalent diseases.
The modified Aq-DNA helix could now help it perform the switch, slipping comfortably in between the rungs that make up the ladder of the DNA helix, and bestowing it with a new found ability to reversibly gain or lose electrons.
Through their studies, when they sandwiched the DNA between a pair of electrodes, they careful controlled their electrical field and measured the ability of the modified DNA to conduct electricity. This was performed using a staple of nano-electronics, a scanning tunneling microscope, which acts like the tip of an electrode to complete a connection, being repeatedly pulled in and out of contact with the DNA molecules in the solution like a finger touching a water droplet.
“We found the electron transport mechanism in the present anthraquinone-DNA system favors electron “hopping” via anthraquinone and stacked DNA bases,” said Tao. In addition, they found they could reversibly control the conductance states to make the DNA switch on (high-conductance) or switch-off (low conductance). When anthraquinone has gained the most electrons (its most-reduced state), it is far more conductive, and the team finely mapped out a 3-D picture to account for how anthraquinone controlled the electrical state of the DNA.
For their next project, they hope to extend their studies to get one step closer toward making DNA nano-devices a reality.
“We are particularly excited that the engineered DNA provides a nice tool to examine redox reaction kinetics, and thermodynamics the single molecule level,” said Tao.
Learn more: Switched-on DNA
[osd_subscribe categories=’DNA-electronics’ placeholder=’Email Address’ button_text=’Subscribe Now for any new posts on the topic “DNA ELECTRONICS”‘]
Receive an email update when we add a new DNA ELECTRONICS article.
The Latest on: DNA electronics
via Google News
The Latest on: DNA electronics
- Super-fast 5G to be rolled out in India in October, says Centre; know spectrum auction detailson August 1, 2022 at 6:26 pm
The 5G telecom network will be rolled out in India in October this year, according to Union Minister Ashwini Vaishnaw’s announcement.
- 'A mountain that just keeps growing.' What to know about the e-waste left behind by your gadgetson August 1, 2022 at 6:26 am
The most recent United Nation's data indicates the world generated a staggering 53.6 million metric tons of e-waste in 2019, and only 17.4% of that was recycled. The burden and ha ...
- Illumina and Best Buy have been highlighted as Zacks Bull and Bear of the Dayon August 1, 2022 at 6:00 am
Zacks Equity Research shares Illumina ILMN as the Bull of the Day and Best Buy BBY asthe Bear of the Day. In addition, Zacks Equity Research provides analysis on Starbucks Corporation SBUX, The ...
- Strange, never-before-seen diamond crystal structure found inside 'Diablo canyon' meteoriteon July 28, 2022 at 1:40 pm
Scientists found something unexpected inside a meteorite that hit Earth 50,000 years ago. While studying diamonds inside an ancient meteorite, scientists have found a strange, interwoven microscopic ...
- Programming pH: New technique could accelerate DNA synthesison July 27, 2022 at 11:00 am
H—the concentration of protons in a watery solution—indicates how acidic the solution is. It regulates a broad range of natural and engineered chemical processes, including the synthesis of designed ...
- Democrats Want to Outlaw Apple From Thinking Differentlyon July 25, 2022 at 12:59 am
Piyas Biswas/SOPA Images/LightRocket via GettyDemocrats are calling on the U.S. Commerce Department to standardize charging ports on smartphones and other consumer electronics, a move inspired by a ...
- QR code labelling on electronics items to de-clutter product info to start soonon July 23, 2022 at 7:23 am
However, the electronic industry will have to declare on the package itself details like MRP, phone number and e-mail address.
- RS Recommends: These DNA Test Kits Are 50% Off for Prime Dayon July 16, 2022 at 2:33 pm
Amazon More from Rolling Stone RS Recommends: The Best Prime Day Tech and Electronics Deals The Best ... from its original price of $119. With this DNA testing kit, you can learn more about ...
- DNA Analysis in the Government Sector Market Growth, Size, Analysis, Outlook by 2022- Trends, Opportunities and Forecast to 2028on July 13, 2022 at 7:42 am
Ultra Electronics Forensic, NetBio, EyeLock, 3M, A-T Solutions, Stanley Black & Decker, and Others. Also, the DNA Analysis in the Government Sector market analysis report includes information on ...
via Bing News