UMass Amherst study finds impaired behavior in pregnant and lactating mice
In the first study of its kind, environmental health scientist Laura Vandenberg and neuroscientist Mary Catanese at the University of Massachusetts Amherst examined the effects of the compound bisphenol S (BPS) on maternal behavior and related brain regions in mice. They found subtle but striking behavior changes in nesting mothers exposed during pregnancy and lactation and in their daughters exposed in utero.
BPS, found in baby bottles, personal care products and thermal receipts, is a replacement chemical for BPA and was introduced when concern was raised about possible health effects of that plastic compound. Though studies have found human BPS exposure is likely low, it is widespread and has increased over the past 10 years, the authors note. As with BPA, there is evidence that BPS is an endocrine disruptor.
Assistant professor Vandenberg and Catanese, a recent graduate of UMass Amherst’s neuroscience and behavior graduate program, report, “BPS affects maternal behavior as well as maternally relevant neural correlates.” Their results suggest that maternal care of pups, including mothers’ ability to adjust to the needs of their young during early development, was impaired after BPS exposure “with differing effects based on dose, postpartum period and generational timing of exposure.”
They note effects including “a surprising increased incidence of infanticide” in one treated group and poor maternal care, for example. Details appear in the current issue of Endocrinology.
For this work, the researchers divided pregnant mice into three treatment groups and administered no BPS or one of two low doses of BPS throughout pregnancy and lactation. The researchers then monitored nest-building, pup care and other maternal behaviors during the nursing period. Further, two female offspring from each of these litters were mated with unexposed male mice and tested for maternal behavior using the same assays used to test their mothers.
Trained observers recorded each mother’s position on or off the nest, self grooming, eating, drinking, sleeping/resting, nest repair and pup grooming at three separate time points after pups were born. Animals were also evaluated on time to retrieve pups that were moved out of the nest, another measure of maternal care.
Further, the researchers examined effects of BPS exposure in a brain region sensitive to estrogen or estrogen-mimicking chemicals that is also believed to be important in maternal behavior in mice.
The authors found a surprising increased incidence of infanticide among mouse mothers exposed to the lower dose in utero. Vandenberg and Catanese report that “although these same effects were not seen at the higher dose, more than 10 percent of females exposed to 2 microgram BPS/kg/day either killed their pups or provided such poor instrumental maternal care that one or more pups needed to be euthanized. While not statistically significant, the neglect and poor maternal care we observed were striking.”
In addition to the effects on infanticide, they also found BPS-induced effects on important aspects of maternal care in both exposed mothers and their daughters. They report that females exposed to the higher dose of BPS during pregnancy and lactation spent significantly more time on the nest than controls at one observation point, an unexpected finding given that mouse mothers usually spend less time on the nest as pups grow and develop. The researchers suggest that the mother’s BPS exposure “may indicate a lack of adjustment” to the changing needs of her pups.
BPS-exposed mothers also showed significantly shorter latency to retrieve their first pup and significantly shorter latency to retrieve their entire litter on one of the three observation days, which may not represent improved care but instead “may indicate hyperactivity, compulsivity-like behavior, heightened stress response to scattered pups, or a displaced form of retrieval.”
Different effects were seen in maternal behaviors of the exposed daughters. BPS-exposed daughters spent significantly less time on the nest compared to unexposed controls. The authors also add, “Observations suggesting an inability to attend to the changing development and needs of the pups may also be extended to measures of nest building.” In the exposed daughters, BPS treatment increased time spent nest building on one of the observation days, which “may indicate a repetitive or OCD-like behavior.”
Overall, Vandenberg and Catanese write that “uncovering effects of environmental chemicals that might influence proper maternal care have broad social and public health implications” because from an evolutionary perspective, maternal behavior is related to survival of offspring.
[osd_subscribe categories=’bps’ placeholder=’Email Address’ button_text=’Subscribe Now for any new posts on the topic “BPS”‘]
Receive an email update when we add a new BPS article.
The Latest on: BPS-induced effects
via Google News
The Latest on: BPS-induced effects
- BP Zone Reviews [Beware Website Alert]: “Zenith Labs BP Zone” Price UK, Canada, Australia & Side Effectson August 5, 2022 at 3:40 am
Zenith Labs BP Zone is a supplement that may help in balancing your disturbed blood pressure levels. Zenith Labs BP Zone Reviews NY, USA: You must have heard about problems related to blood pressure.
- The impact of the Bank of Canada’s Government Bond Purchase Programon August 2, 2022 at 5:19 pm
Our analysis suggests that a $1 billion GoC purchase caused an average decline in yields of about 0.8 bps on purchased bonds on the day of a QE operation (Chart 4). Flow effects may materialize ... in ...
- Live news updates: First grain ship from Ukraine reaches Turkey after months-long blockadeon August 2, 2022 at 2:26 pm
The first grain ship to set sail from Ukraine in months has reached Turkey, marking the completion of a critical first step in a deal aimed at alleviating soaring global food prices. The Sierra ...
- GLOBAL ECONOMY Factories squeezed by higher prices, weak demandon August 1, 2022 at 6:33 am
Factories across the United States, Europe and Asia struggled for momentum in July as flagging global demand and China's strict COVID-19 restrictions slowed production, surveys showed on Monday, ...
- Treatment of Hypertension in Diabeteson July 31, 2022 at 5:01 pm
The reduced levels of angiotensin II lead not only to vasodilatation and a fall in BP but also to a reduction of potential harmful effects of ... and as the hypovolemia-induced rise in renin ...
- Walking pace that induces leg pain may improve walking velocity, leg function in PADon July 27, 2022 at 8:53 am
Walking at a pace that induced ischemic leg pain in patients with lower-extremity peripheral artery disease improved 12-month walking velocity and Short Physical Performance Battery score vs. a pace ...
- Increasingly hawkish central bank assumes ‘firefighter’ stanceon July 17, 2022 at 7:28 pm
Just as the Philippine economy’s bounce back from pandemic-induced recession was gaining ... and the lag between the policies and their effects. “We, of course, know that our forecasts can ...
- UPDATE 4-Euro zone bond yields fall as German inflation cools offon June 29, 2022 at 8:43 am
driven by one-off effects, as an end to price pressures. Nonetheless, Germany’s 10-year government bond yield, the benchmark for the euro zone bloc, was down nearly 13 basis points (bps ...
- Perindopril versus Angiotensin II Receptor Blockade in Hypertension and Coronary Artery Diseaseon June 12, 2022 at 5:00 pm
Although both groups of drugs lower blood pressure, studies of the ACE inhibitor perindopril have revealed preservation of beneficial vascular and endothelial effects mediated by bradykinin and ...
via Bing News