UMass Amherst study finds impaired behavior in pregnant and lactating mice
In the first study of its kind, environmental health scientist Laura Vandenberg and neuroscientist Mary Catanese at the University of Massachusetts Amherst examined the effects of the compound bisphenol S (BPS) on maternal behavior and related brain regions in mice. They found subtle but striking behavior changes in nesting mothers exposed during pregnancy and lactation and in their daughters exposed in utero.
BPS, found in baby bottles, personal care products and thermal receipts, is a replacement chemical for BPA and was introduced when concern was raised about possible health effects of that plastic compound. Though studies have found human BPS exposure is likely low, it is widespread and has increased over the past 10 years, the authors note. As with BPA, there is evidence that BPS is an endocrine disruptor.
Assistant professor Vandenberg and Catanese, a recent graduate of UMass Amherst’s neuroscience and behavior graduate program, report, “BPS affects maternal behavior as well as maternally relevant neural correlates.” Their results suggest that maternal care of pups, including mothers’ ability to adjust to the needs of their young during early development, was impaired after BPS exposure “with differing effects based on dose, postpartum period and generational timing of exposure.”
They note effects including “a surprising increased incidence of infanticide” in one treated group and poor maternal care, for example. Details appear in the current issue of Endocrinology.
For this work, the researchers divided pregnant mice into three treatment groups and administered no BPS or one of two low doses of BPS throughout pregnancy and lactation. The researchers then monitored nest-building, pup care and other maternal behaviors during the nursing period. Further, two female offspring from each of these litters were mated with unexposed male mice and tested for maternal behavior using the same assays used to test their mothers.
Trained observers recorded each mother’s position on or off the nest, self grooming, eating, drinking, sleeping/resting, nest repair and pup grooming at three separate time points after pups were born. Animals were also evaluated on time to retrieve pups that were moved out of the nest, another measure of maternal care.
Further, the researchers examined effects of BPS exposure in a brain region sensitive to estrogen or estrogen-mimicking chemicals that is also believed to be important in maternal behavior in mice.
The authors found a surprising increased incidence of infanticide among mouse mothers exposed to the lower dose in utero. Vandenberg and Catanese report that “although these same effects were not seen at the higher dose, more than 10 percent of females exposed to 2 microgram BPS/kg/day either killed their pups or provided such poor instrumental maternal care that one or more pups needed to be euthanized. While not statistically significant, the neglect and poor maternal care we observed were striking.”
In addition to the effects on infanticide, they also found BPS-induced effects on important aspects of maternal care in both exposed mothers and their daughters. They report that females exposed to the higher dose of BPS during pregnancy and lactation spent significantly more time on the nest than controls at one observation point, an unexpected finding given that mouse mothers usually spend less time on the nest as pups grow and develop. The researchers suggest that the mother’s BPS exposure “may indicate a lack of adjustment” to the changing needs of her pups.
BPS-exposed mothers also showed significantly shorter latency to retrieve their first pup and significantly shorter latency to retrieve their entire litter on one of the three observation days, which may not represent improved care but instead “may indicate hyperactivity, compulsivity-like behavior, heightened stress response to scattered pups, or a displaced form of retrieval.”
Different effects were seen in maternal behaviors of the exposed daughters. BPS-exposed daughters spent significantly less time on the nest compared to unexposed controls. The authors also add, “Observations suggesting an inability to attend to the changing development and needs of the pups may also be extended to measures of nest building.” In the exposed daughters, BPS treatment increased time spent nest building on one of the observation days, which “may indicate a repetitive or OCD-like behavior.”
Overall, Vandenberg and Catanese write that “uncovering effects of environmental chemicals that might influence proper maternal care have broad social and public health implications” because from an evolutionary perspective, maternal behavior is related to survival of offspring.
[osd_subscribe categories=’bps’ placeholder=’Email Address’ button_text=’Subscribe Now for any new posts on the topic “BPS”‘]
Receive an email update when we add a new BPS article.
The Latest on: BPS-induced effects
[google_news title=”” keyword=”BPS-induced effects” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: BPS-induced effects
- Effects of Vitamin D on Immune Disorders With Special Regard to Asthma, COPD and Autoimmune Diseaseson February 15, 2024 at 4:00 pm
VD inhibits the genesis of both Th1- and Th2-cell mediated diseases. The pleiotropic character VD-induced effects are due to the altered transcription of hundreds of genes. VD supplementation in ...
- BSP keeps rate steady as price risks ebbon February 15, 2024 at 7:33 am
By Keisha B. Ta-asan, Reporter THE PHILIPPINE central bank kept its benchmark interest rate — as expected — at a near 17-year high for a third straight meeting on Thursday, as policy makers remained ...
- Salt Subs in Normal BP; Stroke Thrombectomy Without $$; Walmart's CVD Blood Teston February 13, 2024 at 10:12 am
Fewer than half of Americans know their blood pressure or ideal weight, an Ohio State University survey found. In older adults with normal blood pressure, salt substitution was associated with less ...
- 10 Best CBD Creams, Balms And Lotions Of 2024on February 5, 2024 at 11:16 pm
From price to potency to special effects, learn which CBD cream products stand out as our top picks. Note: Prices listed are accurate as of the publication date.
- What Is BPA? Should I Be Concerned About It?on January 28, 2024 at 4:00 pm
This article provides a detailed review of BPA and its potential health effects. Many people worry ... products have replaced BPA with bisphenol-S (BPS) or bisphenol-F (BPF), compounds that ...
- Drug-Induced Effects on Erlotinib Metabolismon January 24, 2024 at 4:00 pm
Two months later, progressive disease with chest pain developed, but neither diarrhea nor skin rash, both expected side effects of erlotinib, was observed. The plasma trough concentration for ...
- Effects of exercise on lymphocytes and cytokineson December 24, 2023 at 2:02 am
The clinical consequences of the exercise induced immune changes have not formally been identified, but the exercise effect on lymphocyte dynamics and immune function may be linked to the exercise ...
- Hypertension in Women: How Blood Pressure-Issues Affect Women Differently - 5 Tips to Manage iton December 20, 2023 at 3:55 pm
While hypertension is more prevalent in men below the age of 50, for women high BP is more after menopause ... women benefit from the protective effects of oestrogen, those who are susceptible ...
- Toprol-xlon June 30, 2022 at 3:53 am
Administration of beta-blockers alone in the setting of pheochromocytoma may cause a paradoxical increase in BP. Limited available ... information regarding the effects of metoprolol on milk ...
via Bing News