The shortening of telomeres in cells was thought to be an important biomarker for lifespan and aging. The edible dormouse (Glis glis), a small hibernating rodent, now turns everything upside down. In contrast to humans and other animals, telomere length in the edible dormouse significantly increases in the second half of its life, as researchers from Vetmeduni Vienna found out just recently.
The study was published in Scientific Reports.
“As far as I know, no previous study has reported such an effect of age on telomere lengthening,” says Franz Hoelzl, one of the authors. Apparently, this unique pattern is due to the peculiar life history of this species. They can reach maximum lifespan of 13 years, which is a Methuselah-like age for a small rodent. “This extreme lifespan is almost certainly related to their ability to rejuvenate telomeres”, says Hoelzl. Telomeres are the endcaps of chromosomes, which prevent, together with proteins, the degradation of coding DNA sequences.
Telomeres in small animals shorten fast, but in edible dormice they even grow
In normal somatic cells, telomeres are shortened with every cell division. Besides, oxidative stress has a strong effect on telomere erosion. However, the rate of telomere shortening differs between species. For instance, it has been shown before that telomeres in fast-aging, short-lived wild animals erode more rapidly than in slow-aging, long-lived species.
Earlier this year, the author Franz Hoelzl and his colleagues from Vetmeduni Vienna showed that edible dormice has the capability to re-elongated its telomeres, given that food availability is high. This finding raised the question about the long-term balance between telomere attrition and repair.
The relative telomere length (RTL) gave evidence
To find an answer, the team started a long-tem study on changes in telomere length. In the Vienna Woods in Austria they regularly checked 130 nest-boxes that are occupied by free-living dormice. The researchers collected the rodent’s buccal mucosa for three years. Thus, they could extract the DNA and determine the relative telomere length for each dormouse individually using qPCR. With this method scientists can define the amount of target DNA compared to a reference gene of the same sample.
Elongation does not only occur, it even increases in older edible dormice
“We found out that the telomeres were shortened in young animals but length significantly increased once the dormice were six years old or older. To top it all, the rate of telomere elongation also increased with increasing age of the dormice”, says Franz Hoelzl.
Among the variables tested, only age significantly affected RTL in a non-linear pattern with telomere length decreasing in younger and increasing in older dormice. Hoelz says, “Telomere length was not affected by time of the year, sex, body mass or reproductive activity at the time of sampling.” Nevertheless, the analysis of long term reproduction-data of the same population shows that the probability to reproduce also increases with age. This finding could indicate that telomere elongation is actually part of the preparation for upcoming reproductive events, as gestation and lactation could increase oxidative stress and the animals may attempt to protect their genome.
The Latest on: Telomeres
via Google News
The Latest on: Telomeres
- Having Successfully Reversed Aging, Extended Longevity, Inc., Opens Fundraise through Wefunderon May 23, 2022 at 7:23 am
The company is currently running medically supervised studies, with independent lab tests revealing that these formulations have regrown telomeres to lengths consistent with preteens ...
- Mice live longer with nasal gene therapyon May 18, 2022 at 3:51 am
Research using nasal gene therapy has successfully extended mice lifespans, providing new hope for human longevity research.
- Telomeres and Telomerases in Canceron May 16, 2022 at 5:00 pm
To understand the role of telomeres in development, cancer and aging, DePinho and colleagues,  at Dana-Farber Cancer Institute in Boston, Massachusetts, developed several mouse models to study ...
- An Electron Micrograph Showing Telomeres in Red (IMAGE)on May 11, 2022 at 4:39 pm
Telomeres shorten progressively over time -- at an average rate of approximately 50-100 base pairs annually. Telomere length is variable, shortening more rapidly under conditions of high ...
- Telomeres and Telomerases in Canceron May 8, 2022 at 5:00 pm
The ends of chromosomes consist of specialized nucleoprotein structures called telomeres that stabilize chromosome ends to help maintain genomic integrity. With each cell division, telomeres ...
- Brisk walking makes body younger, could add years to your life, study showson May 3, 2022 at 8:15 am
Walking fast every day will help you live longer, a new study indicates. A brisk pace is associated with longer telomeres, a biological-age genetic marker, and so a lifetime of speedy walking ...
- Signs of aging in DNA associated with higher COVID-19 death riskon April 25, 2022 at 5:00 pm
Now, new research identifies another risk factor. Shorter telomeres are associated with an increased likelihood of death from COVID-19, particularly in older women, researchers say. Advertisement ...
- Study links telomere length to risk of death from COVID-19on April 22, 2022 at 1:05 am
New research to be presented at this year's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Lisbon, Portugal (23-26 April), suggests that shorter telomeres ...
- Riding Into Old Age Is Beneficial to Your DNA, Which Is Good News for Various Reasonson April 15, 2022 at 11:13 am
According to new research, masters athletes have longer telomeres (which “cap” off the ends of chromosomes and prevent them from fraying) than non-athletes of the same age. This is important ...
via Bing News