Researchers are now working to design stable micro-bubbles which, combined with ultrasound, can deliver cancer drugs straight to the target tumour.
The project recently started up in Trondheim is called ‘BubbleCAN’ and is based on SINTEF proprietary technology. Researchers are making stable micro-bubbles containing chemotherapeutic drugs.
The bubbles can be used in combination with ultrasound and are highly suitable for inoperable cancers and brain tumours that are difficult to treat using current methods.
Highly targeted therapy – fewer side-effects
Yrr Mørch at SINTEF tells Gemini that in traditional chemotherapy approaches, as little as between 0.001 and 0.01% of the drug injected into the body will reach the target tumour.
“The rest damages healthy cells and tissue, resulting in terrible side-effects”, says Mørch. “But when we combine bubbles with ultrasound we can increase the amount of drug delivered directly to the cancer by creating small pores in the walls of the vessels supplying blood to the tumour.
Stable, customised micro-bubbles
The challenge facing researchers is that the bubbles are delicate and only have a restricted lifetime in the bloodstream. There is an urgent need to develop bubbles specially designed for ultrasound-based cancer treatments, but there are currently no such products on the market.
The aim of the BubbleCAN project is to optimise the micro-bubble concept and develop a commercial product.
- You may also read: Stealth Medisine
“The most important task in this project is to make the bubbles stable”, says Mørch. “To do this we need nanoparticles that create a protective shell around the bubbles. The bubbles are injected into the blood and circulate to all parts of the body. When they reach the tumour, targeted ultrasound waves burst the bubbles, releasing the nanoparticles and simultaneously creating small pores in the blood vessel walls. This enables large amounts of nanoparticles to accumulate in the tumour, gradually dissolving and releasing the chemotherapeutic drugs”, says Mørch.
The Latest on: Gas bubbles for cancer drug delivery
[google_news title=”” keyword=”gas bubbles for cancer drug delivery” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Gas bubbles for cancer drug delivery
- Mimicking Nature's Nanocarrier: Synthetic Low-density Lipoprotein-like Nanoparticles for Cancer-drug Deliveryon February 18, 2024 at 4:00 pm
Engineered drugs or diagnostic probes targeted specifically to the patient's disease state promises to improve the efficacy of cancer chemotherapy. Nanocarrier delivery systems are proposed to ...
- “Bubble” CRISPR Delivery System Advances Gene Editing in Living Animalson February 4, 2024 at 4:00 pm
Subscribe for FREE The delivery method, developed in the University of California, Berkeley, laboratory of Jennifer Doudna, co-inventor of CRISPR-Cas9 genome editing, involves wrapping the Cas9 ...
- Researchers develop nanofiber-based drug delivery system for skin canceron January 23, 2024 at 4:00 pm
More information: Baljinder Singh et al, Light-responsive layer-by-layer assembled nanofibers for sequential drug release, Journal of Drug Delivery Science and Technology (2023). DOI: 10.1016/j ...
- Researchers Use Bubbles in Cancer Treatment and Drug Deliveryon December 22, 2023 at 4:27 am
University of Michigan researchers hope to use gas bubbles like corks to block oxygen flow to tumors, or to deliver drugs ... allow very precise delivery because their formation can be controlled ...
- Drug delivery articles from across Nature Portfolioon November 15, 2021 at 11:41 pm
The authors propose a one-step method of incorporating chimeric nanobodies tagged to hydrophobic linkers into liposomes, allowing targeted delivery of small-molecule anti-cancer drugs to tumours.
- DNA nanostructures manipulate cell membranes for optimized drug deliveryon October 19, 2021 at 5:00 pm
The use of liposomes, nanosized ‘bubbles’ of cellular membranes, has been well established in drug delivery for cancer and other diseases. However, there is still much room for improvement in this ...
- Drug Delivery and Molecular Sensingon August 17, 2020 at 6:15 pm
The Drug Delivery and Molecular Sensing (DDMS) Research Program is comprised of faculty members at Purdue University with the mission of providing physical science/engineering and technology solutions ...
- Cancer Drug Delivery Improvedon June 2, 2019 at 10:00 pm
Chemotherapeutic drugs,in controlled doses, is delivered to cancer tissues without harming healthy body cells in a new way found by University of Arizona researchers. If successful, the invention ...
- Smart nanoparticles for cancer drug deliveryon March 29, 2019 at 3:50 am
well-designed delivery system, enhanced toxic responses [in cancerous cells] can be attained,” offering huge potential as selective anti-cancer drug carriers.
- Design and Technology/Chemistry KS3 & KS4: Nano-bubbles and drug deliveryon October 18, 2017 at 7:00 am
Dr Stride explains that cancer drugs are poisonous and have many side effects. Her research uses microscopic bubbles of gas coated with ... one aspect (in this case, delivery).
via Bing News