via momentum.vicc.org
Scientists have demonstrated a method for generating several key types of eye tissue from human stem cells in a way that mirrors whole eye development.
When transplanted to an animal model of corneal blindness, these tissues are shown to repair the front of the eye and restore vision, which scientists say could pave the way for human clinical trials of anterior eye transplantation to restore lost or damaged vision.
A collaborative team comprising researchers from Cardiff University and Osaka University in Japan describe their findings today (embargo: 18:00GMT, 09 March, 2016) in Nature.
The eye is composed of highly specialized tissues that are derived from a variety of cell lineages during development.
Previous studies have demonstrated that particular cell types, such as those that constitute the retina or cornea, can be created in the laboratory from pluripotent stem cells. However, these studies do not represent the complexity of whole eye development.
This latest study reports the generation of multiple cell lineages of the eye, including the lens, cornea, and conjunctiva, using human induced pluripotent stem cells.
The scientists have been able to show that the corneal epithelial cells can be cultivated and transplanted onto the eyes of rabbits with experimentally induced blindness to surgically repair the front of the eye.
Study co-author, Professor Andrew Quantock, said: “This research shows that various types of human stem cells are able to take on the characteristics of the cornea, lens and retina.
“Importantly, it demonstrates that one cell type – the corneal epithelium – could be further grown in the lab and then transplanted on to a rabbit’s eye where it was functional, achieving recovered vision.
“Our work not only holds potential for developing cells for treatment of other areas of the eye, but could set the stage for future human clinical trials of anterior eye transplantation to restore visual function.”
Learn more: Vision restored in rabbits following stem cell transplantation
The Latest on: Stem cell transplantation
via Google News
The Latest on: Stem cell transplantation
- Making stem cell transplants safer and more effectiveon April 21, 2021 at 5:55 pm
For cancer patients, the use of hematopoietic stem cell transplants can be a game changer in terms of treatment and recovery.
- Toward safer stem cell transplantson April 21, 2021 at 5:03 am
A new article in Chemical & Engineering News, the weekly newsmagazine of the American Chemical Society, sheds light on progress toward making stem cell transplants safer and more effective.
- Hematopoietic Stem Cell Transplantation (HSCT) Market Trend, Technology Innovations and Growth Prediction 2021-2026on April 21, 2021 at 4:19 am
The business intelligence report of Hematopoietic Stem Cell Transplantation (HSCT) market is a collection of important datapoints, including prevailing trends, growth ...
- Severe allo-immune antibody-associated peripheral and central nervous system diseases after allogeneic hematopoietic stem cell transplantationon April 19, 2021 at 2:36 pm
Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a curative treatment for hematologic malignancies. Acute and chronic graft-versus-host disease (GvHD) are the major immune-mediated ...
- Ruxolitinib early administration reduces acute GVHD after alternative donor hematopoietic stem cell transplantation in acute leukemiaon April 19, 2021 at 12:16 pm
This study aimed to observe the safety and clinical efficacy of early application of ruxolitinib to prevent acute graft-versus-host disease (aGVHD) after alternative donor transpl ...
- MIPT and Harvard researchers grow and transplant retinal ganglion cells to treat glaucomaon April 19, 2021 at 10:49 am
A joint research carried out by MIPT scientists and Harvard researchers have presented retinal cells that can integrate into the retina.
- Researchers grow stem cells to cure glaucomaon April 19, 2021 at 9:03 am
A joint research effort carried out by MIPT scientists and Harvard researchers has yielded retinal cells that can integrate into the retina. This is the first successful attempt to transplant ganglion ...
- Stem cells embedded into eyes to cure glaucomaon April 19, 2021 at 6:58 am
Researchers present a study that proves stem cells ability to cure glaucoma. It is the world's first successful attempt to grow and transplant retinal ganglion cells in laboratory settings. It ...
- Making stem cell transplants saferon April 18, 2021 at 1:26 pm
Biotech firms hope less harsh, more effective conditioning therapies will expand the kinds of diseases treated by stem cell transplants ...
- Stem cell therapy for kidney transplants has changed since Louisville patient's canceron April 16, 2021 at 3:37 am
The stem cell therapy for kidney transplant patients has changed since the first experiments in Louisville, and it is now showing "promising results." ...
via Bing News
