Imagine telling a patient suffering from age-related (type-II) osteoporosis that a single injection of stem cells could restore their normal bone structure. This week, with a publication in STEM CELLS Translational Medicine, a group of researchers from the University of Toronto and The Ottawa Hospital suggest that this scenario may not be too far away.
Osteoporosis affects over 200M people worldwide and, unlike post-menopausal (type-I) osteoporosis, both women and men are equally susceptible to developing the age-related (type-II) form of this chronic disease. With age-related osteoporosis, the inner structure of the bone diminishes, leaving the bone thinner, less dense, and losing its function. The disease is responsible for an estimated 8.9 M fractures per year worldwide. Fractures of the hip—one of the most common breaks for those suffering from type-II osteoporosis—lead to a significant lack of mobility and, for some, can be deadly.
But how can an injection of stem cells reverse the ravages of age in the bones?
Professor William Stanford, senior author of the study, had in previous research demonstrated a causal effect between mice that developed age-related osteoporosis and low or defective mesenchymal stem cells (MSCs) in these animals.
“We reasoned that if defective MSCs are responsible for osteoporosis, transplantation of healthy MSCs should be able to prevent or treat osteoporosis,” said Stanford, who is a Senior Scientist at The Ottawa Hospital and Professor at the University of Ottawa.
To test that theory, the researchers injected osteoporotic mice with MSCs from healthy mice. Stem cells are “progenitor” cells, capable of dividing and changing into all the different cell types in the body. Able to become bone cells, MSCs have a second unique feature, ideal for the development of human therapies: these stem cells can be transplanted from one person to another without the need for matching (needed for blood transfusions, for instance) and without being rejected.
After six months post-injection, a quarter of the life span of these animals, the osteoporotic bone had astonishingly given way to healthy, functional bone.
“We had hoped for a general increase in bone health,” said John E. Davies, Professor at the Faculty of Dentistry and the Institute of Biomaterials & Biomedical Engineering (IBBME) at the University of Toronto, and a co-author of the study. “But the huge surprise was to find that the exquisite inner “coral-like” architecture of the bone structure of the injected animals—which is severely compromised in osteoporosis—was restored to normal.”
The study could soon give rise to a whole new paradigm for treating or even indefinitely postponing the onset of osteoporosis. Currently there is only one commercially available therapy for type-II osteoporosis, a drug that maintains its effectiveness for just two years.
And, while there are no human stem cell trials looking at a systemic treatment for osteoporosis, the long-range results of the study point to the possibility that as little as one dose of stem cells might offer long-term relief.
“It’s very exciting,” said Dr. Jeff Kiernan, first author of the study. A graduate from IBBME who is beginning a Postdoctoral Fellowship at The Ottawa Hospital with the Centre for Transfusion Research, Kiernan pursued the research for his doctoral degree.
“We’re currently conducting ancillary trials with a research group in the U.S., where elderly patients have been injected with MSCs to study various outcomes. We’ll be able to look at those blood samples for biological markers of bone growth and bone reabsorption,” he added.
If improvements to bone health are observed in these ancillary trials, according to Stanford, larger dedicated trials could follow within the next 5 years.
Learn more: Stem cell therapy reverses age-related osteoporosis in mice
The Latest on: Age-related osteoporosis
[google_news title=”” keyword=”age-related osteoporosis” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Age-related osteoporosis
- How to Age Gracefully: Proven Strategies for Healthy Agingon September 27, 2023 at 11:10 pm
As we journey through life, aging is an inevitable part of the process. While we cannot stop the clock, we can certainly take steps to ensur..|News Track ...
- Blocking Notch Signalling Lessens Age Related Bone Losson September 27, 2023 at 6:01 pm
Ebf3 emerges as a potential drug target to combat age-related osteoporosis. Notch Signaling Impacts Bone Health: A study led by NYU Grossman School of Medicine found that the Notch signaling pathway, ...
- What Is It Like to Get a Bone Mineral Density Scan?on September 27, 2023 at 5:00 pm
Getting tested, when appropriate, can help determine whether you have osteoporosis and are at risk of a serious bone break.
- Coming Soon: NASA-Based Vibration Treatment For Osteoporosison September 27, 2023 at 6:09 am
combat osteoporosis and osteopenia ... This grant supports late-stage research and development and technical assistance programs focusing on age-related health innovations. In partnership with the San ...
- Healthy aging calls for dairy productson September 25, 2023 at 3:22 pm
Muscle and bone health matters at every age. That’s why dairy products are not only an important part of the diet for children as they build muscle and bone density, but also for older adults as they ...
- High Osteoporosis-Related Fracture Risk found in Rheumatoid Arthritis Patientson September 24, 2023 at 7:30 am
In a recent study published in BMC Rheumatology uncovered a heightened risk of osteoporosis-related fractures among individuals with rheumatoid arthritis (RA), shedding light on the significance ...
- The #1 Simple Workout Plan for Women Over 50 With Osteoporosison September 21, 2023 at 3:30 pm
Ready to go? Dr. Brittany Leboeuf, Ph.D., a doctor of exercise science and a certified nutrition coach at Orangetheory Fitness, says women over 50 with osteoporosis should focus on getting 150 minutes ...
- How to Avoid a Stooped Posture as You Ageon September 18, 2023 at 11:00 pm
Growing older, medical problems, and computer use can cause us to hunch over. These strategies can help.By Michele StantenHas standing up straight become more of a challenge? A hunched-over, ...
- End the worry of osteoporosis: exercises backed by science for strong bone health for womenon September 18, 2023 at 6:10 am
Regular exercise has gained substantial recognition for its profound benefits, not only in terms of longevity, but also in preventing various age-related illnesses. Moreover, for women, exercise plays ...
- What are some possible early warning signs of osteoporosis?on September 17, 2023 at 5:00 pm
Many people do not have noticeable symptoms of osteoporosis until they experience an injury or fracture. However, early signs of the condition can include receding gums, weakened grip strength ...
via Bing News