A research team from the University of Liverpool and the University of the West of England (UWE Bristol) has reached an important milestone towards creating a urine diagnostic test for prostate cancer that could mean that invasive diagnostic procedures that men currently undergo eventually become a thing of the past.
‘The use of a gas chromatography (GC)-sensor system combined with advanced statistical methods towards the diagnosis of urological malignancies’, published today in the Journal of Breath Research, describes a diagnostic test using a special tool to ‘smell’ the cancer in men’s urine.
Working in collaboration with the Bristol Urological Institute team at Southmead Hospital andBristol Royal Infirmary, the pilot study included 155 men presenting to urology clinics. Of this group, 58 were diagnosed with prostate cancer, 24 with bladder cancer and 73 with haematuria or poor stream without cancer. The results of the pilot study using the GC sensor system indicate that it is able to successfully identify different patterns of volatile compounds that allow classification of urine samples from patients with urological cancers.
Urgent need for earlier diagnosis
Professor Chris Probert from the University of Liverpool’s Institute of Translational Medicine began work on this project with UWE Bristol when he was working in Bristol as a gastroenterologist with clinical and research interest in inflammatory bowel disease.
The research team used a gas chromatography sensor system called Odoreader that was developed by a team led by Professor Probert and Professor Norman Ratcliffe at UWE Bristol. The test involves inserting urine samples into the Odoreader that are then measured using algorithms developed by the research team at the University of Liverpool and UWE Bristol.
Professor Probert, said: “There is an urgent need to identify these cancers at an earlier stage when they are more treatable as the earlier a person is diagnosed the better. After further sample testing the next step is to take this technology and put it into a user friendly format. With help from industry partners we will be able to further develop the Odoreader, which will enable it to be used where it is needed most; at a patient’s bedside, in a doctor’s surgery, in a clinic or Walk In Centre, providing fast, inexpensive, accurate results.”
Like an electronic nose
Professor Norman Ratcliffe said, “There is currently no accurate test for prostate cancer, the vagaries of the PSA test indicators can sometimes result in unnecessary biopsies, resulting in psychological toll, risk of infection from the procedure and even sometimes missing cancer cases. Our aim is to create a test that avoids this procedure at initial diagnosis by detecting cancer in a non-invasive way by smelling the disease in men’s urine. A few years ago we did similar work to detect bladder cancer following a discovery that dogs could sniff out cancer. We have been using the Odoreader, which is like an electronic nose to sense the cancer.”
The Odoreader has a 30 metre column that enables the compounds in the urine to travel through at different rates thus breaking the sample into a readable format. This is then translated into an algorithm enabling detection of cancer by reading the patterns presented. The positioning of the prostate gland which is very close to the bladder gives the urine profile a different algorithm if the man has cancer.
Mr Raj Prasad, Consultant Urologist at Southmead Hospital, North Bristol NHS Trust, said: “If this test succeeds at full medical trial it will revolutionise diagnostics. Even with detailed template biopsies there is a risk that we may fail to detect prostate cancer in some cases. Currently indicators such as diagnosed prostatomegaly (enlarged prostate) and unusually high PSA levels can lead to recommendations for biopsy if there is a concern that cancer may be prevalent. An accurate urine test would mean that many men who currently undergo prostate biopsy may not need to do so.”
The Latest on: Electronic nose
via Google News
The Latest on: Electronic nose
- Electronic Nose Market Share 2022-2027: Key Vendor Landscape by Regional Output, Demand by Countries and Future Growthon May 12, 2022 at 4:27 am
Electronic Nose Market” industry is estimated to grow highest in the upcoming period as the scope and its applications ...
- Red Nose Dayon May 11, 2022 at 5:25 am
A cornhole tournament is the latest in a series of annual events Columbus Walgreens holds during the month-long Red Nose Day campaign to raise funds for children in poverty. Store Manager Seth ...
- E-bikes are everywhere in Spokane as riders look for a fun assiston May 11, 2022 at 3:39 am
For years I’d thumbed my nose at e-bikes as some sort of crutch for folks who can’t push themselves to the limit. Turns out I’d missed the whole point: Because you’re using less energy, e-Bikes will ...
- Cancer symptoms: Numerous sensations you could feel if a tumour is growing in the noseon May 11, 2022 at 2:17 am
NASAL cancer, while considered rare in the UK, still affects around 460 people each year as they receive a life-threatening diagnosis - and there will be people who simply do not seek help in the ...
- New Ford E-Transit Custom Is an Electric Van With a Funny Faceon May 9, 2022 at 11:08 am
While we only get the massive big-boy Transit and the smaller, now outdated Transit Connect in the US, Ford sells a Transit Custom van in Europe that sits in between the two in terms of size and is ...
- New Approach for Nose Job Without Breaking Boneson May 4, 2022 at 5:57 am
Since the beginning of rhinoplasty, the procedure has been performed with hammers and chisels to break and reposition the bones of the nose. These methods are still commonly used for most surgeons in ...
- Esempi di "by a nose" in una fraseon May 3, 2022 at 8:06 pm
Questi esempi sono stati selezionati automaticamente e possono contenere contenuti sensibili. We welcome feedback: report an example sentence to the Collins team. Leggi tutto ... The car is in the ...
- Cardea Bio receives funding to develop electronic nose to rapidly diagnose infectious diseases via breathon May 3, 2022 at 8:41 am
Developing an electronic nose with the potential to diagnose diseases like COVID, malaria, cancer, and so on, is literally a dream come true!" states Michael Heltzen, CEO at Cardea Bio.
via Bing News