Focus on increasing throughput of processes has favoured poorer models with lower chances of success
The search for new medicines is becoming unsustainably expensive despite huge technological advances because researchers are using the wrong methods, experts say.
They say drug discovery should focus on ‘validity’ – how well the results of experiments predict results in sick people. Instead, it has focused on methods that are easy to industrialize or methods that are academically fashionable.
In a report published in the journal PLOS ONE, Jack Scannell, from Oxford University’s Centre for the Advancement of Sustainable Medical Innovation, and consultant Jim Bosley approach drug discovery using mathematical tools that are used by economists to study decision making. They show that the chance of discovering an effective drug is surprisingly sensitive to the validity of the experimental methods. Small changes in validity can have a bigger effect than running 10 or even 100 times more experiments.
They argue that productivity has declined because the most predictive methods lead to the discovery of good drugs, and research in those areas stops (e.g., stomach ulcers). This leaves scientists working on as-yet-untreated diseases using less predictive discovery methods (e.g., Alzheimer’s). They also suggest that changing industrial and scientific fashions have contributed to the problem.
The result: Methods have become less predictive over time, worse decisions have been made, and the cost of discovery has gone up.
Drug approvals have increased since 2012. The researchers say that this is likely down to the rising use of genetic information which improves the validity of the methods to discover treatments for rare diseases, though less so for common diseases.
Dr Jack Scannell said: ‘There is a nasty puzzle at the heart of modern biomedical research. On one hand, the technologies that people think are important have become hundreds, thousands, or even billions of times cheaper. On the other hand, it costs nearly 100 times more to bring a drug to market today than it did in 1950. New drugs can be very expensive, yet the industry is closing labs and firing scientists. Our work goes some way towards explaining the puzzle. Governments, companies, and charities should focus on identifying and funding predictive methods, even if they don’t match current scientific fashion.’
The Latest on: Drug development crisis
via Google News
The Latest on: Drug development crisis
- Despite those amazing jabs, big pharma shares are ailing - experts say it may be time to get a profit booster - by investing in drug firmson May 8, 2021 at 1:51 pm
The pharmaceuticals and biotechnology index is the second-worst performer out of 40 industrial sectors within the FTSE350 Index over the past year. It has registered a fall of nearly 12 per cent.
- DCGI approves anti-Covid drug developed by DRDO for emergency useon May 8, 2021 at 2:01 am
The Drugs Controller General of India (DCGI) has approved the emergency use of drug 2-deoxy-D-glucose (2-DG) developed by DRDO.
- To filmmaker Gibney, opioid crisis is ‘Crime of the Century’on May 6, 2021 at 1:32 pm
Not unexpectedly given the subject matter, HBO's two-part documentary “The Crime of the Century” opens with a body bag. It contained a man from San Diego — his remains carried away in the predawn ...
- A plan to expand a crisis center introduced to city planningon May 6, 2021 at 9:26 am
A crisis care stabilization center development was introduced at Rapid City’s Panning Commissioners meeting. The center would be a place with many different services provided by the county…a few being ...
- Calls for drug companies to share vaccine formulas grow as global COVID crisis worsenson May 5, 2021 at 12:04 pm
While some of the world's wealthiest nations move closer to mass immunity, dozens of low- and middle-income countries have been left clambering for scarce coronavirus vaccines.
- New PhRMA Report Shows Nearly 90 Medicines in Development to Fight Drug-Resistant Infections, but Future Pipeline Remains Challengingon April 29, 2021 at 4:37 am
Unfortunately, the current treatments were not developed to treat these resistant strains and the pipeline of new antimicrobials needed to stem the tide of AMR has been on the decline. A robust ...
- The pandemic will end, but another crisis awaits: drug costson April 28, 2021 at 10:01 am
But there's another crisis mounting beneath the surface: the persistent unaffordability of prescription drugs. The cost of retail prescription drugs increased by 5.7% in 2019, up from 3.8% in 2018, ...
- Atriva Therapeutics to speed up development of Covid-19 drug with €11.4 million federal fundingon April 23, 2021 at 1:29 am
“Especially in such a global health crisis as this, a broad public funding initiative is extremely important and can be decisive for speeding up the drug development process – as has been impressively ...
- New Method To Fast Track Drug Developmenton April 21, 2021 at 7:16 pm
Findings were published in in Nature Communications Biology and describes how the conclusions can motivate how we may change responses to pandemics and how to address the antibiotic resistance crisis.
- PRESS RELEASE: Atriva Therapeutics to Speed up Development of COVID-19 Drug with Federal Fundingon April 21, 2021 at 9:04 am
"Especially in such a global health crisis as this, a broad public funding initiative is extremely important and can be decisive for speeding up the drug development process - as has been ...
via Bing News