In a first, Japanese researchers have regenerated functional joints in frogs by activating a newly-found “reintegration” mechanism. Further understanding of this process may help transplanted tissues integrate with the original organs and limbs after surgical removal or amputation.
“We expect that by applying this approach to other animals, we may also achieve functional joint regeneration in mammals, including humans, in the future,” says Kyoto University study author Kiyokazu Agata.
Some animals — for instance newts — can regenerate a smaller, but fully functioning limb after the original has become detached. Frogs are considered to be the intermediate between such animals and mammals, that cannot regenerate limbs. Frogs regenerate “spikes”, which are cartilage rods protruding from the disfigured area. These new cartilage limbs lack joints, and are therefore unable to bend at will.
A functional joint requires integration of multiple tissues: two opposing skeletal elements forming an interlocking structure, and muscles which insert into skeletal tissues via tendons across joints. Newts, but not frogs, are capable of reconnecting these tissues.
When a frog limb is detached at an elbow joint, however, the interaction between the remaining and the regenerated tissues affects the regrowth of the regenerated elbow so that it resembles the original tissue more closely. As a result, the tissue attached to the joint is more similar in size to the original limb. The team named this interaction mechanism “reintegration”.
The researchers hope that further understanding of these mechanisms could ultimately bring about limb regeneration in mammals — and in the long run perhaps even humans.
“As a next step we would like to attempt functional joint regeneration in mice by activating the reintegration mechanism,” said Agata.
Read more: Regrowing functional joints in frogs
The Latest on: Regenerative medicine
[google_news title=”” keyword=”regenerative medicine” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Regenerative medicine
- Hydrogel spheres compose a microporous structure for localized mRNA deliveryon February 29, 2024 at 1:52 pm
In a significant leap forward in the realm of regenerative medicine, a team at the Terasaki Institute for Biomedical Innovation has introduced a pioneering approach to mRNA therapy using microspheres ...
- 3D Systems: Another Difficult Year Aheadon February 28, 2024 at 8:54 pm
D Systems is implementing cost-cutting initiatives and focusing on regenerative medicine to stem losses and drive growth. Learn why DDD stock is a Hold.
- Roots Start to Show for Hair Loss Startup Pelage With a Peek at First Clinical Dataon February 28, 2024 at 5:31 pm
Regenerative medicine startup Pelage Pharmaceuticals has clinical data showing its small molecule activated hair follicle stem cells. GV led a Series A round that funded the UCLA spinout’s Phase 1 ...
- Pelage secures funds to develop regenerative medicine for hair losson February 28, 2024 at 4:49 am
Pelage Pharmaceuticals has secured $16.75m in a Series A financing round to further the development of PP405, a promising regenerative treatment for hair loss caused by androgenetic alopecia. GV led ...
- Contour Medical's an all-encompassing approach to regenerative medicine and functional wellnesson February 27, 2024 at 9:11 am
((SL Advertiser)) Contour Medical's an all-encompassing approach to regenerative medicine and functional wellness. To learn more, go to ContourMedical.com ...
- Albert Einstein College of Medicine to offer free tuition after billion-dollar gifton February 26, 2024 at 10:53 am
Students at the Albert Einstein College of Medicine in New York will receive free tuition after a $1 billion dollar donation from a former faculty member.
- Advances in medicine are changing the way stem cells are used, research for Alzheimer’s underwayon February 23, 2024 at 9:26 am
“We've actually seen cord blood and cord tissue being used in newer applications in this newer area of medicine called regenerative medicine,” Isley said. “Regenerative medicine looks to repair and ...
- QC Kinetix Launches Groundbreaking Clinical Trial to Enhance Musculoskeletal Pain Treatment Using Regenerative Medicineon February 22, 2024 at 6:45 am
CHARLOTTE, NC / ACCESSWIRE / February 22, 2024 / QC Kinetix, a leader in the field of regenerative medicine, announces the launch of a new ...
- 3D bioprinting landmark breakthroughs signify turning point in regenerative medicineon February 22, 2024 at 4:52 am
Stratasys: GlobalData’s proprietary technology innovation intelligence tool ‘Technology Foresights’ indicates a consistent increase in the number of patents associated with 3D bioprinting over the ...
- Regenerative Medicine Market Size, Share, Industry Analysis, Trends, Forecast 2024-2032on February 21, 2024 at 6:14 pm
(MENAFN- IMARC Group) According to the latest report by IMARC Group, titled“ Regenerative Medicine Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2024-2032 ”, offers a ...
via Bing News