Thermal ablation with magnetic resonance–guided focused ultrasound surgery (MRgFUS) is a noninvasive technique for treating fibroids and cancer. New research from UC Davis shows that combining the technique with chemotherapy can allow complete destruction of tumors in mice.
MRgFUS combines an ultrasound beam that heats and destroys tissue with a magnetic resonance imaging to guide the beam and monitor the effects of treatment. The effectiveness of the treatment can be limited by the need to spare normal tissue or critical structures on the tumor margins, as well as the need to eliminate micrometastases.
In a new paper in The Journal of Clinical Investigation, Katherine W. Ferrara, distinguished professor of biomedical engineering at UC Davis, and colleagues report on a strategy that can destroy an entire tumor without thermal destruction of the tumor margin. Her group demonstrated a dramatic increase in the concentration of anti-cancer chemotherapy within several types of MRgFUS thermal ablation-treated tumors.
“MRgFUS is already FDA approved for the treatment of uterine fibroids and palliation of bone metastases. We hope to expand the indication for MRgFUS by supplementing it with chemotherapy,” said first author Andrew Wong, a graduate student with the UC Davis Physician Scientist Training Program.
Ferrara’s previous research has shown that ultrasound-induced mild hyperthermia can enhance the accumulation of tiny nanoparticles carrying anti-cancer drugs, but the accumulation is dependent on the type of tumor. Her group hypothesized that combining thermal ablation and chemotherapy could improve efficacy across multiple types of tumors.
The team used a variety of techniques including combined positron emission tomography/computed tomography (PET-CT), magnetic resonance imaging, autoradiography, and fluorescence imaging to track nanoparticles loaded with the chemotherapy drug doxorubicin in a mouse model of breast cancer.
They found that as the ultrasound damaged the tumor and induced a local immune response, nanoparticles accumulated in the tumor and the local drug concentration increased 50-fold. The high drug concentrations continued over several weeks, increasing total exposure of the tumor to the drug.
Ferrara’s research team found that the enhanced drug accumulation induced by MRgFUS resulted in improved survival and a consistent cure in their preclinical model of breast cancer, even when part of the tumor was left intact.
They also demonstrated that an effective cure could be achieved with a carefully designed protocol involving heat-activated nanoparticles, which, when gently heated by ultrasound, release their chemotherapeutic payload in the vasculature surrounding the tumor.
The Latest on: MRgFUS
via Google News
The Latest on: MRgFUS
- Dr. Ehdaie weighs in on focal therapy with MRgFUS for GG2/3 prostate canceron September 14, 2021 at 6:54 am
This device is unique in that because it's done during real-time MRI imaging while the patient is in the MRI machine, [we] can monitor the temperatures achieved by our treatment in real time and make ...
- MR-guided focal therapy emerges as alternative to radical therapy for intermediate-risk prostate canceron September 14, 2021 at 5:40 am
Magnetic resonance–guided focused ultrasound (MRgFUS) may be an effective alternative to radical therapy that improves outcomes for sexual function and urinary incontinence in men with ...
- Global Ablation Technology Market to Witness Tremendous Growth in Forecasted Period 2021-2028on September 9, 2021 at 7:45 am
DBMR has added a new report titled Global Ablation Technology Market with analysis provides the insights which bring marketplace clearly into the focus and thus help organizations make better ...
- HIFU Treatment That Preserves Women's Fertility Now Available In Malaysiaon September 8, 2021 at 10:48 pm
A non-invasive procedure to treat uterine fibroids known as High-Intensity Focused Ultrasound (HIFU) is set to change the treatment landscape for women nationwide. According to Mahkota Medical Centre ...
- Ultrasound Ablators Market 2021 Report Enlightening Development Scope and Business Strategies Developed By Leading Vendorson September 3, 2021 at 4:37 am
Magnetic Resonance Guided Focused Ultrasound (Mrgfus) Ablators, Others), By Applications (Cardiovascular Disease, Cancer, Ophthalmologic, Gynecologic, Pain Management, others), By End users ...
- MR-Guided Focused Ultrasound for the Novel and Innovative Management of Osteoarthritic Knee Painon August 20, 2021 at 5:00 pm
MRgFUS treatment had a potential of rapid and long-lasting pain alleviation without adverse side effects. Significant increase of PPTs on treated area showed successful denervation effect on the ...
- MR-Guided Focused Ultrasound for the Novel and Innovative Management of Osteoarthritic Knee Painon August 7, 2021 at 5:01 pm
This is the first report of clinical application of MRgFUS for knee OA. Real-time monitoring of the sonication area and temperature elevation enabled performance of safe and accurate treatment.
- The Technology Redefining Surgery: MR-Guided Focused Ultrasoundon August 4, 2021 at 5:00 pm
Looking Ahead: The Impact of MRgFUS on Patients and Physicians MR-guided focused ultrasound devices have been adopted and are being used by physicians in more than 80 leading medical facilities in the ...
- Missing Treatment Optionon May 7, 2015 at 6:05 am
The authors discuss numerous treatments of fibroids (1), including MR-guided focused ultrasound surgery (MRgFUS/MRgHIFU). However, no reference is made to the option of ultrasound-guided high ...
- What Is Magnetic Resonance Guided Focused Ultrasound For Fibroids? - Dr. LeBlang (VIDEO)on January 31, 2015 at 12:50 am
The focused ultrasound part, which is the FUS part of MRgFUS, stands for Focused Ultrasound, and that’s where we take a normal ultrasound beam and guide it into the fibroid to generate enough heat ...
via Bing News