Researchers at North Carolina State University and the University of North Carolina at Chapel Hill have developed a new drug delivery technique that uses a biodegradable liquid metal to target cancer cells. The liquid metal drug delivery method promises to boost the effect of cancer drugs. To date, the technique has only been tested in an animal model.
“The advance here is that we have a drug-delivery technique that may enhance the effectiveness of the drugs being delivered, can help doctors locate tumors, can be produced in bulk, and appears to be wholly biodegradable with very low toxicity,” says Zhen Gu, corresponding author of a Nature Communications paper on the work and an assistant professor in the joint biomedical engineering program at NC State and UNC-CH. “And one of the advantages of this technique is that these liquid metal drug carriers – or ‘nano-terminators’ – are very easy to make.”
To create the nano-terminators, researchers place the bulk liquid metal (gallium indium alloy) into a solution that contains two types of molecules called polymeric ligands. The solution is then hit with ultrasound, which forces the liquid metal to burst into nanoscale droplets approximately 100 nanometers in diameter. The ligands in the solution attach to the surface of the droplets as they break away from the bulk liquid metal. Meanwhile, an oxidized “skin” forms on the surface of the nanodroplets. The oxidized skin, together with the ligands, prevents the nanodroplets from fusing back together.
The anticancer drug doxorubicin (Dox) is then introduced into the solution. One of the ligands on the nanodroplet sucks up the Dox and holds on to it. These drug-laden nanodroplets can then be separated from the solution and introduced into the bloodstream.
The second type of ligand on the nanodroplets effectively seeks out cancer cells, causing receptors on the surface of the cancer cell to latch on to the nanodroplets. The cancer cell then absorbs the nanodroplets.
Once absorbed, the higher level of acidity inside the cancer cell dissolves the oxidized skin of the nanodroplets. This releases the ligands, which will go on to release the Dox inside the cell.
“Without the oxidized skin and ligands, the nanodroplets fuse together, forming larger drops of liquid metal,” says Michael Dickey, a co-author on this paper and professor in the Department of Chemical and Biomolecular Engineering at NC State. “These larger droplets are fairly easy to detect using diagnostic techniques, which can potentially help doctors locate tumors.”
Meanwhile, the liquid metal continues reacting with the acidic environment in the cancer cell and dissolves, releasing gallium ions. Interestingly, these gallium ions enhance the performance of anticancer drugs – including their effectiveness against drug-resistant cell lines.
In addition, this process gradually degrades the metal, minimizing long-term toxicity.
“Based on in vitro tests, we believe the liquid metal degrades completely in a matter of days into a form that the body can successfully absorb or filter out, without notable toxic effects,” says Yue Lu, a Ph.D. student in Gu’s lab.
The researchers have tested the liquid metal technique in a mouse model, and found that it is significantly more effective than Dox alone at inhibiting the growth of ovarian cancer tumors. Importantly, the researchers tracked the mice for up to 90 days, and found no signs of toxicity related to the liquid metal.
“This was a proof-of-concept study, but very encouraging,” Gu says. “Like the fictional Terminator, this carrier is transformable: smashed from bulk material, fused inside cancer cells and eventually degraded and cleared. We are hoping to do additional testing in a large animal study to get closer to potential clinical trials.”
Read more: Liquid Metal ‘Nano-Terminators’ Target Cancer Cells
The Latest on: Nano-Terminators
[google_news title=”” keyword=”Nano-Terminators” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Nano-Terminators
- How Instagram nano influencers make money with under 10,000 followerson March 16, 2023 at 5:00 pm
An envelope. It indicates the ability to send an email. An curved arrow pointing right. "Nano" influencers may only have a few thousand followers, but that's not keeping them from turning a social ...
- "Terminator habitability" not in the realm of sci-fi, says researchon March 16, 2023 at 12:38 pm
The area between these two sides is called the "terminator zone" and is a logical place to search for other life in the galaxy, says a new study. Much like the Moon is to Earth, many planets are ...
- 'Terminator zones' on distant planets could harbor lifeon March 16, 2023 at 10:08 am
'Terminator zones' on distant planets could harbor life These in-between regions could be prime sites for liquid water Date: March 16, 2023 Source: University of California - Irvine Summary: In a ...
- 'Terminator zones' on distant planets could harbor life, astronomers sayon March 15, 2023 at 5:00 pm
One key to the finding, Lobo added, was pinpointing exactly what kind of terminator zone planet can retain liquid water.If the planet is mostly covered in water, then the water facing the star ...
- Terminator 3: What Makes It Such A Good Sequel?on March 14, 2023 at 9:02 am
Terminator 3 is one of the films in the franchise that's been ridiculed for being similar to Cameron's films, but why is it actually a worthy sequel? While The Terminator sequels overall haven't ...
- PowerA Nano Enhanced Wired Controller Reviewon March 13, 2023 at 6:20 pm
PowerA’s Nano Enhanced Wired Controller tackles the problem head-on with a controller that comes in significantly smaller than first-party offerings. It also maintains the excellent performance ...
- Best Nano Cap Stocks Right Nowon March 12, 2023 at 5:00 pm
Investors who are looking for higher risk and more potential profit often turn to nano-cap stock options. A nano cap stock is a stock with a total market capitalization below $50 million.
- Coinbase hit with proposed trademark lawsuit over Nano derivative productson February 26, 2023 at 7:44 pm
Crypto exchange Coinbase has been named as a defendant in a legal complaint brought by NanoLabs — the company behind the digital currency Nano (NANO) — over alleged trademark infringement.
- Repair Stuck IPod Nano Buttonson February 22, 2023 at 6:01 pm
A system is only as strong as its weakest link and [Roberto Barrios] found that on the sixth generation iPod nano the buttons are the problem. It makes sense that the buttons would be exposed to ...
- Nano-optics from sensing to waveguidingon September 10, 2022 at 12:59 am
The design and realization of metallic nanostructures with tunable plasmon resonances has been greatly advanced by combining a wealth of nanofabrication techniques with advances in computational ...
via Bing News