By isolating cells into a monolayer within a fluid via acoustic levitation, a group of Utah Valley University researchers created a new method to detect cell stiffness — enabling exploration of cell changes that occur during the metastasis of cancer or other diseases.
Utah Valley University physicists are literally applying rocket science to the field of medical diagnostics. With a few key changes, the researchers used a noninvasive ultrasonic technique originally developed to detect microscopic flaws in solid fuel rockets, such as space shuttle boosters, to successfully detect cell stiffness changes associated with certain cancers and other diseases.
Brian Patchett, a research assistant and instructor within the Department of Physics at Utah Valley University, will describe the group’s method, which uses sound waves to manipulate and probe cells, during the Acoustical Society of America’s Fall 2015 Meeting, held Nov. 2-6, in Jacksonville, Fla.
The method combines a low-frequency ultrasonic wave to levitate the cells and confine them to a single layer within a fluid and a high-frequency ultrasonic wave to measure the cell’s stiffness.
“An acoustic wave is a pressure wave so it travels as a wave of high and low pressure. By trapping a sound wave between a transducer — such as a speaker — and a reflective surface, we can create a ‘standing wave’ in the space between,” explained Patchett. “This standing wave has stationary layers of high and low pressure, a.k.a. ‘anti-nodes,’ and areas, ‘the nodes’ where the pressure remains the same.”
This standing wave allowed the group to acoustically levitate the cells and isolate them in manner similar to their natural state — as they would be within human tissue or the bloodstream. Previous work in this realm relied on “growing the cell cultures in a Petri dish, which tends to deform the structure, as well as create all sorts of interference,” Patchett said.
The significance of the group’s work is that it focuses on an unexplored method of measuring the properties of cells and how they change during the process of cancer and disease development. “The stiffness of the cell is the primary change detected with our high-frequency ultrasound; it reveals detailed information about the internal structure of the cell and how it changes in certain diseases,” Patchett said.
The group’s method can also help distinguish between different types of cancer — such as aggressive breast cancer vs. less aggressive forms. “By isolating the cells in a monolayer of fluid via acoustic levitation, we’re providing a better method for the detection of cell stiffness,” Patchett said. “This method can be used to explore the aspect of cells that changes during Alzheimer’s disease, the metastasis of cancer, or during the onset of autoimmune responses to better understand these conditions and provide insight into possible treatment methods.”
The Latest on: Acoustic levitation
via Google News
The Latest on: Acoustic levitation
- Using Acoustic Levitation For Applications Going Way Beyond Noveltyon April 10, 2021 at 4:59 pm
We’ve all seen acoustic levitation, it’s one of the scientific novelties of our age and a regular on the circuit of really impressive physical demonstrations of science to the public.
- Acoustic Levitation With A Twiston April 8, 2021 at 5:00 pm
It looks like a lot of fun. Acoustic levitation is nothing new here – we’ve covered 3D acoustic airbending, as well as an acoustic flip-dot display. Being able to control the power of sound ...
- Design approach of perforated labyrinth-based acoustic metasurface for selective acoustic levitation manipulationon April 7, 2021 at 2:03 am
This paper proposes a metasurface design approach with perforated labyrinthine path coil structure to manipulate the acoustic transmission with inexpensive materials. The medium in the ...
- ISS: Gravitational Effects on the Faraday Instabilityon March 15, 2021 at 5:00 pm
Validation of models by irrefutable evidence gathered under a well-controlled, unique microgravity environment have the potential to be translatable to other important fields such as acoustic, ...
- Window and Door Systems - EBE 85 ASon August 11, 2020 at 6:58 pm
EBE 85 AS combines top-level insulation with excellent air and water-tightness, resistance to wind load and acoustic insulation.
- Ultrasonic Hands Could Give Robots a Lighter Touchon January 23, 2020 at 2:11 pm
Schuck can suspend a small object between the two halves of the sphere — a phenomenon called “acoustic levitation.” Schuck now plans to survey experts from various industries to explore ...
- Extreme commitment to progresson December 23, 2018 at 1:07 am
Their electrostatic, electromagnetic and acoustic levitation techniques offer new approaches for materials preparation and property measurement. They have explored containerless preparation of ...
- Scientists Used a Tractor Beam to Levitateon April 4, 2018 at 1:53 pm
Acoustic levitation uses this wave to balance against gravity. The result is a free-floating particle that looks a little like science fiction magic. Dialing in the sound waves means lifting ...
- Could We Levitate Humans With the World’s Most Powerful Acoustic Tractor Beam?on January 22, 2018 at 7:17 am
Acoustic tractor beams use sound, or more specifically soundwaves, to hold particles in mid-air. While magnetic levitation also exists, acoustic levitation tends to work better for handling ...
- Nanobiotechnology and Nanomedicine Companieson November 10, 2017 at 5:42 pm
Develops and manufactures acoustic droplet ejection (ADE ... a device for culturing cells in three-dimensions by magnetic levitation. The Bio-Assembler combines nanoparticle based Nanoshuttle-PL with ...
via Bing News