By isolating cells into a monolayer within a fluid via acoustic levitation, a group of Utah Valley University researchers created a new method to detect cell stiffness — enabling exploration of cell changes that occur during the metastasis of cancer or other diseases.
Utah Valley University physicists are literally applying rocket science to the field of medical diagnostics. With a few key changes, the researchers used a noninvasive ultrasonic technique originally developed to detect microscopic flaws in solid fuel rockets, such as space shuttle boosters, to successfully detect cell stiffness changes associated with certain cancers and other diseases.
Brian Patchett, a research assistant and instructor within the Department of Physics at Utah Valley University, will describe the group’s method, which uses sound waves to manipulate and probe cells, during the Acoustical Society of America’s Fall 2015 Meeting, held Nov. 2-6, in Jacksonville, Fla.
The method combines a low-frequency ultrasonic wave to levitate the cells and confine them to a single layer within a fluid and a high-frequency ultrasonic wave to measure the cell’s stiffness.
“An acoustic wave is a pressure wave so it travels as a wave of high and low pressure. By trapping a sound wave between a transducer — such as a speaker — and a reflective surface, we can create a ‘standing wave’ in the space between,” explained Patchett. “This standing wave has stationary layers of high and low pressure, a.k.a. ‘anti-nodes,’ and areas, ‘the nodes’ where the pressure remains the same.”
This standing wave allowed the group to acoustically levitate the cells and isolate them in manner similar to their natural state — as they would be within human tissue or the bloodstream. Previous work in this realm relied on “growing the cell cultures in a Petri dish, which tends to deform the structure, as well as create all sorts of interference,” Patchett said.
The significance of the group’s work is that it focuses on an unexplored method of measuring the properties of cells and how they change during the process of cancer and disease development. “The stiffness of the cell is the primary change detected with our high-frequency ultrasound; it reveals detailed information about the internal structure of the cell and how it changes in certain diseases,” Patchett said.
The group’s method can also help distinguish between different types of cancer — such as aggressive breast cancer vs. less aggressive forms. “By isolating the cells in a monolayer of fluid via acoustic levitation, we’re providing a better method for the detection of cell stiffness,” Patchett said. “This method can be used to explore the aspect of cells that changes during Alzheimer’s disease, the metastasis of cancer, or during the onset of autoimmune responses to better understand these conditions and provide insight into possible treatment methods.”
The Latest on: Acoustic levitation
via Google News
The Latest on: Acoustic levitation
- These levitating beads can teach physicists about spinning celestial objectson April 29, 2022 at 11:30 am
“Acoustic levitation is a really cool way to manipulate objects, because it’s literally using something very much like a loudspeaker,” says lead study author Melody Lim, an experimental soft matter ...
- Willie Nelson at the peak of his powers, Bloc Party attempt a comeback – the week’s best albumson April 29, 2022 at 2:50 am
Given the circumstances surrounding its creation, there is unsurprisingly a sadness at the heart of Two Ribbons, but even in quieter moments such as the acoustic Strange Conversations ... uplifting ...
- Let’s Eat Grandma: Two Ribbons review – an unforgettably powerful study of friendshipon April 28, 2022 at 5:00 am
Written amid grief and separation, the duo’s third album uses beautiful melodies and Top 40 choruses to consider their evolving bond ...
- Let’s Eat Grandma – Two Ribbonson April 28, 2022 at 1:31 am
For all the sonic invention which they usually display, it’s the raw emotion and sadness which make this their finest album yet It’s fair to say that Let’s Eat Grandma have been through a lot. Not ...
- Acoustic Levitation With A Twiston April 11, 2022 at 5:00 pm
It looks like a lot of fun. Acoustic levitation is nothing new here – we’ve covered 3D acoustic airbending, as well as an acoustic flip-dot display. Being able to control the power of sound ...
- Using Acoustic Levitation For Applications Going Way Beyond Noveltyon April 4, 2022 at 5:00 pm
We’ve all seen acoustic levitation, it’s one of the scientific novelties of our age and a regular on the circuit of really impressive physical demonstrations of science to the public.
- 2018 Award Winnerson March 26, 2020 at 11:49 am
presented in this image is the titanium oxide deposited in aluminum oxide. Image width is 0.05 mm. Acoustic Levitation by Aleks Labuda, Oxford Instruments, California, USA. This micro-photograph ...
- Could We Levitate Humans With the World’s Most Powerful Acoustic Tractor Beam?on January 22, 2018 at 7:17 am
Acoustic tractor beams use sound, or more specifically soundwaves, to hold particles in mid-air. While magnetic levitation also exists, acoustic levitation tends to work better for handling ...
- Physicists Successfully Levitate Large Objects With Sound Waveson August 15, 2016 at 12:56 pm
The objects’ size, at most, was a quarter of the wavelength of an acoustic wave ... The cause of levitation actually changes previous experiments involving the small objects had them trapped ...
via Bing News