An excess of bacteria in the gut can change the way the liver processes fat and could lead to the development of metabolic syndrome, according to health researchers.
Metabolic syndrome is a group of conditions including obesity, type 2 diabetes, high blood pressure, high blood sugar and excess body fat around the waist. People experiencing three or more of these conditions are considered to have metabolic syndrome and are vulnerable to liver and heart diseases. Approximately 20 to 25 percent of adult Americans have the syndrome, according to the American Heart Association.
Research supported by the National Institutes of Health has recommended that Americans add more fiber to their diets because higher fiber diets have been found to improve many aspects of health. However in a certain segment of the population, this advice could be doing more harm than good.
“It is a common misconception that plant-derived dietary fiber contains zero calories,” said Matam Vijay-Kumar, assistant professor of nutritional sciences and medicine at Penn State.
While it’s true that neither people nor mice can digest plant-derived fiber, their gut bacteria can readily ferment the fibers and then release them as energy-rich short-chain fatty acids, such as acetic acid. Once they reach the liver, these compounds convert into lipids and add to fat deposits that could potentially lead to the development of metabolic syndrome, especially in people and mice lacking toll-like receptor 5 (TLR5).
TLR5 is a receptor for bacterial flagellin and is part of the innate immune system that maintains gut-bacteria homeostasis, keeping gut bacteria from over-proliferating. Approximately 10 percent of the human population has a genetic mutation in TLR5, resulting in a complete lack of its function, according to Vijay-Kumar. These individuals have a weakened immune system that may increase the risk of developing metabolic syndrome.
“Our present study suggests that bacterial fermentation of dietary fiber and the production of short-chain fatty acids contribute to deposition of fat in the liver,” said Vijay-Kumar, adding that it may be detrimental to the liver if these processes become dysregulated, especially in individuals with excess gut bacteria commonly associated with intestinal and liver disorders.
Short-chain fatty acids may be beneficial to the host’s health, but could be unfavorable in certain contexts where dysregulated gut bacteria generate uncontrolled short-chain fatty acids for a prolonged period of time.
In the current study, published today (Oct. 29) in the journal Cell Metabolism, the researchers found a link between unchecked bacterial fermentation, short-chain fatty acids and increased liver lipids — which can cause non-alcoholic fatty liver disease, leading to liver damage. They also found that overconsumption of dietary fiber may have adverse consequences in mice with compromised TLR5 function and gut bacterial overgrowth.
“Most of the observations describing the beneficial effects of short-chain fatty acids in metabolic disorders are from short-term studies and primarily from healthy subjects and experimental animals,” said Vishal Singh, postdoctoral fellow in nutritional sciences, Penn State. “Our next goal is to analyze the long-term effects of short-chain fatty acids, specifically in experimental models of type 2 diabetes and/or metabolic syndrome. We envision that our studies would drive the field towards ‘personalized’ cautioned dietary intake of plant-derived fiber in immunocompromised individuals.”
The Latest on: Gut bacteria
[google_news title=”” keyword=”Gut bacteria” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Gut bacteria
- Gut bacteria diversity linked to body weight, athletes show healthier profileson February 29, 2024 at 7:58 pm
The role of the gut microbiome in the human body The human gut microbiome comprises millions of microorganisms, particularly bacteria, which significantly contribute to normal body functioning. The ...
- Surprising Link Found Between Gut Bacteria And Vision Losson February 29, 2024 at 2:30 pm
According to a new mouse study, gut bacteria may cause vision loss in certain eye diseases, which could potentially be treated with antibiotics. Researchers from China and the UK discovered bacteria ...
- Restricting Your Diet in the Name of Gut Health Can Exacerbate Digestive (and Mental Health) Issues. Here’s Whyon February 29, 2024 at 7:24 am
How elimination diets work is that certain foods are initially eliminated from your diet, then gradually reintroduced to help you better identify what things might be contributing to symptoms like ...
- 3 easy dinner recipes by a gut health dietitian who eats 30 plants a weekon February 28, 2024 at 4:04 am
A gut health dietitian shares three easy dinner recipes. She buys 10 types of vegetables and lots of whole grains weekly and combines them into meals.
- Some Cases of Blindness are Linked to Gut Bacteriaon February 27, 2024 at 8:44 am
Trillions of microbes live in the human gastrointestinal tract, and this community of microbes known as the gut microbiome has been linked to many aspects | Cell And Molecular Biology ...
- Gut bacteria may cause blindness due to some inherited eye conditions: Studyon February 26, 2024 at 10:19 pm
The international study observed that in eyes with sight loss caused by a particular genetic mutation, known to cause eye diseases that lead to blindness, gut bacteria were found within the damaged ...
- Gut bacteria may be responsible for sight loss in certain inherited eye diseaseson February 25, 2024 at 3:59 pm
Sight loss in certain inherited eye diseases may be caused by gut bacteria, and is potentially treatable by antimicrobials, finds a new study in mice co-led by a UCL and Moorfields researcher.
- Biodiversity of gut bacteria is associated with sexual behavioron February 25, 2024 at 3:59 pm
Although certain groups of bacteria dominate the human gut microbiome, the exact composition varies from person to person. For example, bacteria from the Prevotellaceae family and the associated ...
- Blindness from some inherited eye diseases may be caused by gut bacteriaon February 25, 2024 at 3:59 pm
Sight loss in certain inherited eye diseases may be caused by gut bacteria, and is potentially treatable by antimicrobials, finds a new study in mice.
- The surprising link between gut bacteria and devastating eye diseaseson February 25, 2024 at 3:59 pm
Finding raises hopes that antibiotics could treat some genetic diseases that can cause blindness — but also prompts doubts.
via Bing News