University of Wisconsin scientists have succeeded in growing functional vocal-cord tissue in the laboratory, a major step toward restoring a voice to people who have lost their vocal cords to cancer surgery or other injuries.
Dr. Nathan Welham, a speech-language pathologist, and colleagues from several disciplines, were able to bioengineer vocal-cord tissue able to transmit sound, they reported in a study published today in the journal Science Translational Medicine.
About 20 million Americans suffer from voice impairments, and many have damage to the vocal-cord mucosae, the specialized tissues that vibrate as air moves over them, giving rise to voice.
While injections of collagen and other materials can help some in the short term, Welham says not much can be done for people who have had larger areas of their vocal cords damaged or removed.
Voice is a pretty amazing thing, yet we don’t give it much thought until something goes wrong,” says Welham, an associate professor of surgery in the UW School of Medicine and Public Health. “Our vocal cords are made up of special tissue that has to be flexible enough to vibrate, yet strong enough to bang together hundreds of times per second. It’s an exquisite system and a hard thing to replicate.”
Welham and colleagues began with vocal-cord tissue from a cadaver and four patients who had their larynxes removed but did not have cancer. They isolated, purified and grew the cells from the mucosa, then applied them to a 3-D collagen scaffold, similar to a system used to grow artificial skin in the laboratory.
In about two weeks, the cells grew together to form a tissue with a pliable but strong connective tissue beneath, and layered epithelial cells on top. Proteomic analysis showed the cells produced many of the same proteins as normal vocal cord cells. Physical testing showed that the epithelial cells had also begun to form an immature basement membrane which helps create a barrier against pathogens and irritants in the airway.
Welham says the lab-grown tissue “felt like vocal-cord tissue,” and materials testing showed that it had qualities of viscosity and elasticity similar to normal tissue.
The Latest on: Vocal-cord tissue
via Google News
The Latest on: Vocal-cord tissue
- She’s only 6 years old and has endured 34 surgeries, with many more to come. ‘It’s OK, though’ says Eden Tansey.on October 8, 2021 at 1:52 pm
The surgeon gave Lisa Tansey an incisive diagnosis and a shocking prognosis after operating on her 18-month-old daughter. “Your daughter’s airway was 90% blocked. She most likely had a week ...
- Ella Eyre ‘had to learn to sing again’ after operation on her vocal cordson October 7, 2021 at 12:38 am
Ella Eyre has revealed she “basically had to learn how to sing and speak again” after an operation on her vocal cords ... in December to remove scar tissue she believes could date back ...
- Ella Eyre ‘had to learn to sing again’ after operation on her vocal cordson October 6, 2021 at 11:00 pm
Ella Eyre has revealed she “basically had to learn how to sing and speak again” after an operation on her vocal cords, but described it as “the best thing” she has ever done. The singer, 27, underwent ...
- Diagnosis and Management of Vocal Cord Dysfunctionon October 6, 2021 at 4:59 pm
Care must be taken not to anesthetize the vocal cords. Direct laryngoscopy is done in an operating room and is performed if tissue samples are needed or growths need to be removed from the vocal ...
- Vocal cordson October 1, 2021 at 6:16 am
In humans, vocal cords, also known as vocal folds or voice reeds, are folds of tissue in the throat that are key in creating sounds through vocalization. The size of vocal cords affects the pitch of ...
- Health Matters 9/24: Therapy Can Help Treat Voice and Swallowing Disorderson September 21, 2021 at 7:50 pm
Most people take swallowing and vocalizing for granted — they are simply spontaneous activities that people do hundreds of times a day without giving them a second thought. But with age, or as a ...
via Bing News