Models of hearts, arteries, bones and brains are 3-D printed out of biological materials
As of this month, over 4,000 Americans are on the waiting list to receive a heart transplant. With failing hearts, these patients have no other options; heart tissue, unlike other parts of the body, is unable to heal itself once it is damaged. Fortunately, recent work by a group at Carnegie Mellon could one day lead to a world in which transplants are no longer necessary to repair damaged organs.
“We’ve been able to take MRI images of coronary arteries and 3-D images of embryonic hearts and 3-D bioprint them with unprecedented resolution and quality out of very soft materials like collagens, alginates and fibrins,” said Adam Feinberg, an associate professor of Materials Science and Engineering and Biomedical Engineering at Carnegie Mellon University. Feinberg leads the Regenerative Biomaterials and Therapeutics Group, and the group’s study was published in the October 23 issue of the journal Science Advances. A demonstration of the technology can be viewed online.
“As excellently demonstrated by Professor Feinberg’s work in bioprinting, our CMU researchers continue to develop novel solutions like this for problems that can have a transformational effect on society,” said Jim Garrett, Dean of Carnegie Mellon’s College of Engineering. “We should expect to see 3-D bioprinting continue to grow as an important tool for a large number of medical applications.”
Traditional 3-D printers build hard objects typically made of plastic or metal, and they work by depositing material onto a surface layer-by-layer to create the 3-D object. Printing each layer requires sturdy support from the layers below, so printing with soft materials like gels has been limited.
“3-D printing of various materials has been a common trend in tissue engineering in the last decade, but until now, no one had developed a method for assembling common tissue engineering gels like collagen or fibrin,” said TJ Hinton, a graduate student in biomedical engineering at Carnegie Mellon and lead author of the study.
“The challenge with soft materials — think about something like Jello that we eat — is that they collapse under their own weight when 3-D printed in air,” explained Feinberg. “So we developed a method of printing these soft materials inside a support bath material. Essentially, we print one gel inside of another gel, which allows us to accurately position the soft material as it’s being printed, layer-by-layer.”
One of the major advances of this technique, termed FRESH, or “Freeform Reversible Embedding of Suspended Hydrogels,” is that the support gel can be easily melted away and removed by heating to body temperature, which does not damage the delicate biological molecules or living cells that were bioprinted. As a next step, the group is working towards incorporating real heart cells into these 3-D printed tissue structures, providing a scaffold to help form contractile muscle.
Bioprinting is a growing field, but to date, most 3-D bioprinters have cost over $100,000 and/or require specialized expertise to operate, limiting wider-spread adoption. Feinberg’s group, however, has been able to implement their technique on a range of consumer-level 3-D printers, which cost less than $1,000 by utilizing open-source hardware and software.
The Latest on: 3-D bioprinting
[google_news title=”” keyword=”3-D bioprinting” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: 3-D bioprinting
- Bioprinting: Donor hearts from 3D printers?on February 22, 2024 at 5:06 pm
Could 3D-printed organs be the solution? For years, international researchers have striven to print functional organs from living cells. Skip next section More on Digital World from Europe ...
- Perspectives on 3D Bioprinting: Conversation with Vidmantas Šakalys from Vital3Don February 22, 2024 at 8:45 am
Charles R. Goulding and Andressa Bonafe sit down for a chat with Vidmantas Šakalys, co-founder and CEO of Vital3D Technologies.
- 3D bioprinting landmark breakthroughs signify turning point in regenerative medicineon February 22, 2024 at 4:52 am
Stratasys: GlobalData’s proprietary technology innovation intelligence tool ‘Technology Foresights’ indicates a consistent increase in the number of patents associated with 3D bioprinting over the ...
- Mother of MS boy detained for public urination files $2 million lawsuiton February 22, 2024 at 2:10 am
Watch this segment to experience the cutting-edge world of 3-D bioprinting with graduate student Blass Watson on Live at Nine. Learn how this innovative method combines traditional 3-D printing ...
- Understanding the Complexity of the Human Heart with 3D Bioprintingon February 20, 2024 at 7:03 am
Researchers in Montreal have turned to 3D bioprinting to create a "heart on a chip" which could be used to study the organ.
- Bioinks with improved electromechanical properties for 3D printing of cardiac BioRingson February 14, 2024 at 1:45 pm
Justine, affiliated with Université de Montreal, have developed a device that accurately simulates the electrical activity, mechanics and physiology of a human heart.
- Students create 3D-bioprinting system to replicate chemicals in plantson February 6, 2024 at 10:21 am
Students engineer an affordable bioprinter to improve how we produce essential pharmaceuticals without relying on actual plants.
- 3D Bioprinting in Medical Market to Reach $4.9 Billion, Globally, by 2032 at 15.5% CAGR: Allied Market Researchon January 21, 2024 at 4:00 pm
Rise in prevalence of chronic diseases, surge in usage of 3D bioprinting in biomedical applications, and advancements in 3D bioprinting drive the growth of the global 3D bioprinting in medical ...
- Global 3D Bioprinting Market Report 2022 to 2027: Rise in Focus on 3D Organ Bioprinting Presents Opportunitieson November 13, 2022 at 4:01 pm
Dublin, Nov. 14, 2022 (GLOBE NEWSWIRE) -- The "3D Bioprinting Market - Global Outlook and Forecast 2022-2027" report has been added to ResearchAndMarkets.com's offering. The global 3D Bioprinting ...
via Bing News