via University of Sheffield
Scientists from the University of Sheffield have discovered MRI scanners, normally used to produce images, can steer cell-based, tumour busting therapies to specific target sites in the body.
Magnetic resonance imaging (MRI) scanners have been used since the 1980s to take detailed images inside the body – helping doctors to make a medical diagnosis and investigate the staging of a disease.
An international team of researchers, led by Dr Munitta Muthana from the University of Sheffield’s Department of Oncology, have now found MRI scanners can non-invasively steer cells, which have been injected with tiny super-paramagnetic iron oxide nanoparticles (SPIOs), to both primary and secondary tumour sites within the body.
This targeted approach is extremely beneficial for patients as it dramatically increases the efficiency of treatment and drug doses could potentially be reduced – helping to alleviate side effects.
Revolutionary cell-based therapies, which exploit modified human cells to treat diseases such as cancer, have advanced greatly over recent years. However, targeted application of cell-based therapy in specific tissues, such as those lying deep in the body where injection is not possible, has remained problematic.
The new research suggests MRI scanners are the key to administering treatments directly to both primary and secondary tumours wherever they are located in the body.
The study, published today (date) in Nature Communications shows that cancer mouse models injected with immune cells carrying SPIOs and armed with the cancer killing oncolytic virus (OV) which infects and kills cancer cells, showed an 800 per cent increase in the effects of the therapy.
Dr Munitta Muthana, from the University of Sheffield, said: “Our results suggest that it is possible to use a standard MRI scanner to naturally deliver cell-based therapies to both primary and secondary tumours which would normally be impossible to reach by injection.
“This not only increases the therapeutic efficacy but also decreases the risk of unwanted side effects.
“The beauty of using the MRI scanner to administer the therapy is that you can also use it for its original purpose providing a real-time image-guide to ensure the treatment has gone where it is needed.”
Read more: MRI scanners can steer tumour busting viruses to specific target sites within the body
The Latest on: Tumour busting therapies
[google_news title=”” keyword=”tumour busting therapies” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Tumour busting therapies
- Breast cancer treatment: Oncologist reveals how treatment options have evolved over the yearson June 6, 2023 at 4:47 am
Unlike traditional chemotherapy that targets all the cells of the body especially the rapidly dividing cells, targeted therapies focus on specific molecules specially on cancer cells involved in its ...
- Fine-tuning 3D lab-grown mini tumors to help predict how patients respond to cancer therapieson June 6, 2023 at 2:00 am
Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a new method to bioprint miniature tumor organoids that are designed to mimic the function and architecture of real tumors.
- Is Focal Therapy the Future for Prostate Cancer?on June 3, 2023 at 4:59 pm
Focal therapy aims to find a middle ground between surveillance and radical therapies by treating the cancer alone, with a margin, and preserving as much tissue as is practical. Early feasibility ...
- Immunotherapy for Melanomaon June 1, 2023 at 5:00 pm
This "second generation version" of immunotherapy works by increasing the number of cancer-busting T-cells ... with chimeric antigen receptor T-cell therapy, or CAR-T, in treating lymphoma ...
- Man Sees Cancer Disappear After a Month of Advanced Therapyon May 31, 2023 at 11:15 pm
The 61-year-old had received CAR-T cell therapy—one of the most advanced cancer treatments developed to date. It involves removing and isolating immune cells known as T lymphocytes, or T cells ...
- Management of Neuroendocrine Tumors: Current and Future Therapieson May 31, 2023 at 5:01 pm
Somatostatin analogs (e.g., octreotide, lanreotide) will continue to be main therapies for functioning neuroendocrine tumors over the next years. Pasireotide, a new panreceptor analog, might ...
- Anocca raises SEK 400 million for large-scale development of cancer cell therapieson May 30, 2023 at 11:01 pm
Each active TCR identified by Anocca can be further developed into a highly specialised cancer treatment, or a "TCR-T" therapy. "We appreciate the opportunity to invest in such an interesting and ...
- Anocca raises SEK 400 million for large-scale development of cancer cell therapieson May 30, 2023 at 10:42 pm
Get 7 Days Free Sign In Sign In Topics ...
- Radiation for prostate cancer: What does it involve?on May 25, 2023 at 5:00 pm
Radiation therapy can be an effective treatment for prostate cancer. It can shrink a tumor, relieve symptoms, and delay or halt the growth of cancer cells. A therapist may target a tumor with an ...
- Pharmacovigilance – News and Featureson May 16, 2023 at 9:07 pm
Scientists from the University of Sheffield have discovered MRI scanners, normally used to produce images, can steer cell-based, tumour busting therapies to specific target sites in the body.
via Bing News
One Comment
Thomas Prevenslik
MRI to direct nanoparticles (NPs) to a cancer cell is a great idea. It may be simpler and economically better to intravenously inject biodegradable 80 nm NPs in to the blood stream, the NPs sized to emit low levels of UV, the UV killing the cancer by damaging the reproductive DNA of the cancer. With patients tested positive for Covid-19, the virus is killed in vivo and the killed virus acts as the antigen to elict immunity. See the “Nanoparticle Treatment” at nanoQED.org , 2020.