A pH-responsive polymer gel could create swallowable devices, including capsules for ultra-long drug delivery
Medical devices designed to reside in the stomach have a variety of applications, including prolonged drug delivery, electronic monitoring, and weight-loss intervention. However, these devices, often created with nondegradable elastic polymers, bear an inherent risk of intestinal obstruction as a result of accidental fracture or migration. As such, they are usually designed to remain in the stomach for a limited time.
Now, researchers at MIT’s Koch Institute for Integrative Cancer Research and Massachusetts General Hospital (MGH) have created a polymer gel that overcomes this safety concern and could allow for the development of long-acting devices that reside in the stomach, including orally delivered capsules that can release drugs over a number of days, weeks, or potentially months following a single administration.
This polymer is pH-responsive: It is stable in the acidic stomach environment but dissolves in the small intestine’s near-neutral pH, allowing for safe passage through the remainder of the gastrointestinal (GI) tract. The material is also elastic, allowing for the compression and folding of devices into easily ingestible capsules — meaning this polymer can be used to create safe devices designed for extremely prolonged residence in the stomach.
“One of the issues with any device in the GI tract is that there’s the potential for an obstruction, which is a medical emergency potentially requiring surgical intervention,” says Koch Institute research affiliate Giovanni Traverso, also a gastroenterologist at MGH and an instructor at Harvard Medical School. “A material like this represents a real advance because it is both safe and stable in the stomach environment.”
Traverso and Robert Langer, the David H. Koch Institute Professor at MIT and a member of the Koch Institute, are the senior authors of a paper in the July 27 issue of Nature Materials that describes the application of this new polymer gel for creating gastric devices. Shiyi Zhang, a postdoc at the Koch Institute, is the paper’s lead author.
Designing devices for the stomach is a complicated matter of sizes and shapes. The stomach naturally empties its contents in a matter of hours, so for devices to be retained, they must be wider than the pylorus — the valve at the end of the stomach, about 1.5 to 2 centimeters in diameter, that allows gastric contents to pass into the small intestine. However, because the most convenient path to deliver these devices is through the esophagus, which is only marginally wider than the pylorus, the researchers were interested in developing a polymer with elastic properties.
“An elastic device can be folded into something small, such as a capsule, and be easily ingested through the esophagus before expanding in the stomach, restoring its original shape,” Zhang says. “When you have a device that’s larger than the pylorus, there’s a much higher probability that it will be retained longer in the stomach.”
But the size and shape of existing devices with elastic polymers have been limited by safety concerns, as there is a greater risk for fracture if a device is too large or too complex. Because of this, the researchers wanted their polymer to also be enteric — or have a mechanism that would enable it to pass through the stomach unaltered before disintegrating in the intestines.
“To lower any possible risk of obstruction, we wanted a material that could dissolve in the intestines, thereby dissociating the device, and safely pass out of the body,” Zhang says.
To create this new material, the researchers synthesized an elastic polymer and combined it in solution with a clinically utilized enteric polymer. Adding hydrochloric acid and centrifuging the solution resulted in a flexible, yet resilient, polymer gel that exhibits both elastic and enteric properties.
The researchers used the gel polycaprolactone (PCL), a nontoxic, degradable polyester, to construct several device prototypes. They first created ring-shaped devices by using the gel to link arcs of PCL in a circular mold. These elastic devices had a diameter of 3 centimeters — wider than the pylorus — before they were folded into orally ingestible capsules.
In testing the capsules in pigs, the researchers found that the rings expanded into their original shape within 15 minutes of ingestion and remained in the stomach for up to seven days. After the device passed out of the stomach, the polymer gel dissolved, allowing for the safe passage of the small PCL pieces without obstruction. The researchers also created larger devices in various shapes that could be folded and delivered through the esophagus with the assistance of an endoscope. These devices remained in the stomach for up to five days, after which the gel similarly dissolved, allowing for the remnants of the device to safely pass.
The Latest on: Long-acting pills
via Google News
The Latest on: Long-acting pills
- 2 Reasons This Will Be Gilead’s Year, Says Morgan Stanleyon January 19, 2021 at 3:50 pm
Analyst Matthew Harrison raised his rating on the stock from a Hold to a Buy, setting a price target of $83. If he proves right, there’s still more than 20% upside to the stock.
- Luye’s schizophrenia drug approval in China challenges J&J’s Risperdal Constaon January 19, 2021 at 3:48 pm
Luye Pharma Group Ltd. won marketing approval in China for its risperidone microspheres for injection to treat schizophrenia, which the company said is the first formulation developed by a Chinese ...
- Attitudes Toward Long-acting Injectable HIV Therapy May Vary Among Womenon January 19, 2021 at 8:30 am
A recent study sought to investigate the attitudes of women with a history of injection—both medical and substance use—toward long-acting injectable HIV therapies.
- Diabetes Devices and Drugs Market to Score Past US$ 231909.8 Million Valuation by 2023, Owing to R& - PharmiWeb.comon January 18, 2021 at 3:17 am
Diabetes may give rise to other conditions related to the eyes, nervous system, heart, kidney, and skin. There are several types of insulin used in the treatment of diabetes that include, rapid-acting ...
- Gilead Stock 2021: Why The Biotech Stock Isn't Depending On Covid Drugson January 16, 2021 at 1:16 am
Gilead Sciences (GILD) isn't betting its 2021 on coronavirus treatment Veklury. But the biotech company still sees plenty of catalysts for ...
- A much-hyped CV drug failed, repeatedly. Now, investors are betting nearly $200M on one last PhIII bidon January 14, 2021 at 4:41 am
Eli Lilly announced early results for a new drug that lowered bad cholesterol and raised good cholesterol. It was a ...
- Teva's long-acting schizophrenia drug hits goal in phase 3on January 11, 2021 at 9:25 am
A phase 3 clinical trial of an extended-release formulation of the antipsychotic drug risperidone has met its primary endpoint. The study boosts Teva’s efforts to establish a presence in the market ...
- PATHways provides second chance for pregnant moms struggling with substance use disorderon January 8, 2021 at 10:02 pm
By Allison Perry University of Kentucky After more than a decade of struggling with addiction, Fleming County resident Marie Vice found herself at a low point, taking herself to a local hospital in ...
- Study explores women's interest in long-acting injectable antiretroviral therapyon January 7, 2021 at 4:09 pm
A study led by Columbia University Mailman School of Public Health researchers examines attitudes toward long-acting injectable (LAI) HIV therapies, among women with a history of injection--including ...
- Integral Molecular and Optimeos Partner to Deliver Long-acting Therapeutic Antibodies Using Nanoparticle Formulation Technologyon January 7, 2021 at 12:00 pm
Integral Molecular and Optimeos Life Sciences have partnered to develop antibody therapeutics using long-acting, sustained ...
via Bing News