Ben-Gurion University of the Negev (BGU) and University of Colorado researchers have developed a dynamic “smart” drug that targets inflammation in a site-specific manner and could enhance the body’s natural ability to fight infection and reduce side effects.
The uniqueness of this novel anti-inflammatory molecule, reported in the current issue of Journal of Immunology, can be found in a singular property. When injected, it is as a non-active drug. However, a localized site with excessive inflammation will activate it. Most other anti-inflammatory agents effectively inhibit inflammatory processes, though in a non-specific manner and in areas that include sites of necessary normal inflammatory homeostasis.
“This development is important because inhibition of inflammation in a non-specific manner reduces the natural ability to fight infections and is a common side effect of anti-inflammatory biologic therapeutics,” says Dr. Peleg Rider of BGU’s Department of Clinical Biochemistry and Pharmacology.
When a non-specific agent is used, any patient who suffers from local inflammation might then be exposed to opportunistic infections at distant sites, such as lungs, risking, for example, tuberculosis. This risk is mainly of concern to immunosuppressed patients, as well as older patients and patients undergoing chemotherapy as part of an anti-cancer treatment course.
“The beauty of this invention lies in the use of a known natural biological code,” Dr. Rider explains. “We mimicked a natural process that occurs during inflammation.”
The protein molecule is actually a chimera comprised of two domains, both originating from the potent inflammatory cytokine family of IL-1. The first part of the protein holds the functional part of the molecule inactive, as occurs in normal living cells, and is connected to a potent natural inhibitor of IL-1. When it encounters inflammatory enzymes, the molecule is cleaved and the functional part becomes active.
Read more: BGU Develops “Smart” Drug to Reduce Inflammation
The Latest on: Inflammation Research
[google_news title=”” keyword=”Inflammation Research” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Inflammation Research
- Potential Drug Target Identified for Infection, Inflammation and Hemolytic Diseaseson June 5, 2023 at 2:04 am
Researchers have found a key ‘on’ switch, called NLRP12, for innate immune cell death in diseases that cause red blood cells to rupture, which can lead to inflammation and multi-organ failure.
- Anxiety, Your Brain, and Long COVID: What the Research Sayson June 4, 2023 at 1:34 pm
The ramifications of the research linking anxiety ... “The first and most mainstream mechanism for long COVID is chronic inflammation and immune dysregulation,” she said. “Several mental health ...
- 5 Best CBD Oil for Pain & Inflammation: 2023 Updateon June 1, 2023 at 10:00 pm
Possibly our favorite part of the job of finding the top 5 CBD oil brands for pain and inflammation was the hours of research and testing to determine which CBD oil brands consistently produced the ...
- New Insight into Brain Inflammation Inspires New Hope for Epilepsy Treatmenton June 1, 2023 at 7:37 pm
Clinicians and researchers teamed up to investigate how inappropriate proinflammatory mechanisms contribute to the pathogenesis of drug-refractory epilepsy.
- NLRP12 as a new drug target for infection, inflammation and hemolytic diseaseson June 1, 2023 at 10:55 am
Infections and other diseases can cause red blood cells to rupture, releasing the oxygen-binding molecule hemoglobin, which breaks down into heme. Free heme can cause significant inflammation and ...
- St. Jude finds NLRP12 as a new drug target for infection, inflammation and hemolytic diseaseson May 31, 2023 at 5:01 pm
Scientists at St. Jude Children’s Research Hospital found key “on” switch, NLRP12, for innate immune cell death in diseases that cause red blood cells to rupture, which can lead to inflammation and ...
- New study reveals Alzheimer’s inflammation protectionon May 30, 2023 at 8:56 am
A possible explanation has been found in a study for why apoE4, associated with Alzheimer’s, fails to protect the brain from inflammation.
- Connection between immune system and brain in mice may explain why stress can worsen gut inflammationon May 29, 2023 at 6:20 am
A team of medical researchers affiliated with multiple institutions in the U.S. and the Netherlands has found a connection between the immune system and the brain in mice that could explain why ...
- Alzheimer’s development: Study reveals why apoE4 gene fails to protect the brain from inflammationon May 25, 2023 at 9:59 am
A possible explanation has been found in a study for why apoE4, the most significant genetic risk factor associated with Alzheimer's disease, fails to protect the brain from inflammation.
- 10 Best CBD Creams for Back Pain in 2023: Cost, Potency, and Moreon May 23, 2023 at 5:00 pm
Some studies suggest CBD can treat physical pain and inflammation, though research is ongoing. THC is the compound, or cannabinoid, responsible for the “high” that people associate with cannabis.
via Bing News