It’s a notion that might be pulled from the pages of science-fiction novel – electronic devices that can be injected directly into the brain, or other body parts, and treat everything from neurodegenerative disorders to paralysis.
It sounds unlikely, until you visit Charles Lieber’s lab.
A team of international researchers, led by Lieber, the Mark Hyman, Jr. Professor of Chemistry, an international team of researchers developed a method for fabricating nano-scale electronic scaffolds that can be injected via syringe. Once connected to electronic devices, the scaffolds can be used to monitor neural activity, stimulate tissues and even promote regenerations of neurons. The study is described in a June 8 paper in Nature Nanotechnology.
Contributing to the work were Jia Liu, Tian-Ming Fu, Zengguang Cheng, Guosong Hong, Tao Zhou, Lihua Jin, Madhavi Duvvuri, Zhe Jiang, Peter Kruskal, Chong Xie, Zhigang Suo, Ying Fang
“I do feel that this has the potential to be revolutionary,” Lieber said. “This opens up a completely new frontier where we can explore the interface between electronic structures and biology. For the past thirty years, people have made incremental improvements in micro-fabrication techniques that have allowed us to make rigid probes smaller and smaller, but no one has addressed this issue – the electronics/cellular interface – at the level at which biology works.”
The idea of merging the biological with the electronic is not a new one for Lieber.
In an earlier study, scientists in Lieber’s lab demonstrated that the scaffolds could be used to create “cyborg” tissue – when cardiac or nerve cells were grown with embedded scaffolds. Researchers were then able to use the devices to record electrical signals generated by the tissues, and to measure changes in those signals as they administered cardio- or neuro-stimulating drugs.
“We were able to demonstrate that we could make this scaffold and culture cells within it, but we didn’t really have an idea how to insert that into pre-existing tissue,” Lieber said. “But if you want to study the brain or develop the tools to explore the brain-machine interface, you need to stick something into the body. When releasing the electronics scaffold completely from the fabrication substrate, we noticed that it was almost invisible and very flexible like a polymer and could literally be sucked into a glass needle or pipette. From there, we simply asked, would it be possible to deliver the mesh electronics by syringe needle injection, a process common to delivery of many species in biology and medicine – you could go to the doctor and you inject this and you’re wired up.'”
Though not the first attempts at implanting electronics into the brain – deep brain stimulation has been used to treat a variety of disorders for decades – the nano-fabricated scaffolds operate on a completely different scale.
“Existing techniques are crude relative to the way the brain is wired,” Lieber explained. “Whether it’s a silicon probe or flexible polymers…they cause inflammation in the tissue that requires periodically changing the position or the stimulation. But with our injectable electronics, it’s as if it’s not there at all. They are one million times more flexible than any state-of-the-art flexible electronics and have subcellular feature sizes. They’re what I call “neuro-philic” – they actually like to interact with neurons..”
Despite their enormous potential, the fabrication of the injectable scaffolds is surprisingly easy.
“That’s the beauty of this – it’s compatible with conventional manufacturing techniques,” Lieber said.
Read more: Injectable electronics
The Latest on: Injectable electronics
[google_news title=”” keyword=”Injectable electronics” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Injectable electronics
- Outside ‘boundaries of the law’: On video, Idaho Harm staff discuss drug-item giveawayson March 1, 2024 at 1:01 pm
We are very, very careful for every order that we send out. ... We let people know ... that this is a very big risk for utilizing these services.” ...
- 10 Most Powerful Cruisers Under $20,000on February 29, 2024 at 5:59 am
Innovations and developments have been observed in almost all the sections, be it design, technology, electronics, or last but not least ... With a compression ratio of 12:1 and electronic fuel ...
- Samsung Electronics Co Ltd 005930on February 28, 2024 at 10:30 pm
We sell different types of products and services to both investment professionals and individual investors. These products and services are usually sold through license agreements or subscriptions ...
- Tesla-Valve-inspired Injection Manifold Design Could Improve Performance of Rotating Detonation Engineson February 28, 2024 at 8:10 am
Researchers at Purdue University's College of Engineering are conducting tests on a patented Tesla valve-inspired injection manifold design to improve the efficiency of rotating detonation engines ...
- Surge in syphilis cases drives some doctors to ration penicillinon February 26, 2024 at 7:00 am
But this already difficult situation was complicated last spring by a shortage of a specific penicillin injection that is the go-to treatment for syphilis. The ongoing shortage is so severe that ...
- Injectable drug significantly reduces kids' reactions to food allergenson February 25, 2024 at 3:59 pm
A study led by Johns Hopkins Children's Center shows omalizumab—an injectable, Food and Drug Administration-approved medication for treating asthma and other allergic conditions—substantially reduced ...
- First Long-Acting Injectable HIV Treatment Works Better Than Daily Pills For Some Patients, GSK Sayson February 21, 2024 at 3:21 am
British pharma giant GSK on Wednesday announced promising results for a long-acting injectable HIV therapy, offering a hopeful alternative for people who take daily pills to halt the virus’s ...
- GSK's injectable HIV drug shows promise over daily pillson February 21, 2024 at 12:17 am
Feb 21 (Reuters) - British drugmaker GSK (GSK.L), opens new tab said on Wednesday its long-acting injectable HIV therapy showed promise in keeping the viral load suppressed compared to daily oral ...
- GSK's injectable HIV drug shows promise over daily pillson February 20, 2024 at 4:00 pm
(Reuters) - British drugmaker GSK said on Wednesday its long-acting injectable HIV therapy showed promise in keeping the viral load suppressed compared to daily oral treatment, especially in ...
- What is injection molding toolon February 11, 2024 at 12:00 pm
Opinions expressed by Entrepreneur contributors are their own.
via Bing News