An international scientific team has successfully created a three-dimensional model of a cancerous tumour using a 3D printer. Their model could ultimately help discover new drugs and cast new light on how tumours develop, grow and spread.
Presented in the IOP Publishing journal Biofabrication, the realistic 3D model consists of a scaffold of fibrous proteins coated in cervical cancer cells. A 10mm by 10mm grid structure – made from gelatin, alginate and fibrin – recreates the fibrous proteins that make up the extracellular matrix of a tumour. The grid structure is coated in Hela cells: a unique, “immortal” cell line that was originally derived from a cervical cancer patient in 1951.
The most effective way of studying tumours is in a clinical trial. However, ethical and safety limitations make it difficult for such studies to be carried out on a wide scale. To overcome this, two-dimensional models – consisting of a single layer of cells – have been created to mimic the physiological environment of tumours and test anti-cancer drugs in a realistic way.
With the advent of 3D printing, it is now possible to provide a more realistic representation of the environment surrounding a tumour. The researchers demonstrated this by comparing results from their 3D model with results from a 2D model.
After testing if the cells remained viable, or alive, after printing, the researchers examined how the cells proliferated, how they expressed a specific set of proteins that help tumours spread, and how resistant the cells were to anti-cancer drugs.
They found that 90% of the cancer cells remained viable after the printing process. In addition, the 3D model shared more similarities with a tumour than 2D models including a higher proliferation rate, higher protein expression and higher resistance to anti-cancer drugs.
“We have provided a scalable and versatile 3D cancer model that shows a greater resemblance to natural cancer than 2D cultured cancer cells,” says the lead author, Professor Wei Sun of Tsinghua University in China and Drexel University in the United States.
The researchers are now trying to understand both cell-cell and cell-substrate communication and immune responses for their printed tumour-like models. “With further understanding of these 3D models, we plan to use them to study the development, invasion, metastasis and treatment of cancer using specific cancer cells from patients,” says Professor Sun. “We can also use these models to test the efficacy and safety of new cancer treatment therapies and cancer drugs.”
The Latest on: 3D tumour model
[google_news title=”” keyword=”3D tumour model” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: 3D tumour model
- International MedTech Company KARL STORZ Acquires King’s College London’s 3D Medical Modelling Spin-Outon February 23, 2024 at 4:23 pm
Innersight Labs, a cutting-edge AI-powered medical software company spun-out from the School of Biomedical Engineering & Imaging Sciences at King's College London, has been acquired by leading ...
- Terahertz biosensor: Light waves see through skin to detect cancer earlyon February 21, 2024 at 2:27 am
The biosensor leverages these waves to provide a non-invasive method for analyzing underlying tissue properties.
- 3D Cell Cultures Market 2024-2028: Global Demand for 3D Cell Culture Solutions Surges with Expanding Biotechnology Applicationson February 20, 2024 at 8:09 pm
Disease modeling: 3D cell culture models can be used to study the biology of diseases and to develop new treatments. For example, 3D cancer models can be used to study tumor growth and metastasis, and ...
- MIT’s Albumin-based cancer vaccine shows promising results in trialson February 17, 2024 at 9:38 am
MIT's albumin-based cancer vaccine shows promise in clinical trials, yielding robust immune responses, raising hope for effective cancer treatment.
- Novel approach improves CAR T-cell therapy efficacy against acute myeloid leukemiaon February 13, 2024 at 5:13 am
St. Jude Children's Research Hospital scientists improved chimeric antigen receptor (CAR) T–cell immunotherapy for acute myeloid leukemia (AML), demonstrating better efficacy in the lab.
- 3D Printed Pelvis And Femur Implants For Bone Cancer Treatmenton February 5, 2024 at 7:23 pm
This replacement with a prosthetic was a first for cancer treatments in Vietnam ... explains the treatment process using 3D printed implant models. (Credit: Vietnam.vn) This kind of hip prosthesis ...
- Artificial oral mucosa as a model for testing dental biomaterialson February 4, 2024 at 4:00 pm
Hence, they investigated the possible use of oral cancer cells as an alternative to NOK for 3D models. Their results indicated that 3D-co-cultures of NOK and oral cancer cells reacted similarly to ...
- Lab-grown tumors predict treatment outcomes in landmark studyon February 2, 2024 at 7:27 am
The world-first study led by WEHI (based in Melbourne, Australia) found drug testing on tumor organoids—3D cancer models grown from a patient's own tissue—could show how they will respond to a ...
- Lab-grown tumors predict treatment outcomes in landmark studyon February 1, 2024 at 4:00 pm
Researchers have grown tumors in the lab to accurately predict which drugs will work for people with bowel cancer—before they begin treatment. The world-first study led by WEHI (based in ...
- Southampton surgeons use 3D printed liver model in UK firston February 1, 2024 at 10:16 am
Arjun Takhar from University Hospital Southampton said the study was a "unique opportunity" Surgeons have begun using 3D-printed models of patients' livers to help them perform a complex cancer ...
via Bing News