An injection of stem cells into the eye may soon slow or reverse the effects of early-stage age-related macular degeneration, according to new research from scientists at Cedars-Sinai
Currently, there is no treatment that slows the progression of the disease, which is the leading cause of vision loss in people over 65.
“This is the first study to show preservation of vision after a single injection of adult-derived human cells into a rat model with age-related macular degeneration,” said Shaomei Wang, MD, PhD, lead author of the study published in the journal STEM CELLS and a research scientist in the Eye Program at the Cedars-Sinai Board of Governors Regenerative Medicine Institute.
The stem cell injection resulted in 130 days of preserved vision in laboratory rats, which roughly equates to 16 years in humans.
Age-related macular degeneration affects upward of 15 million Americans. It occurs when the small central portion of the retina, known as the macula, deteriorates. The retina is the light-sensing nerve tissue at the back of the eye. Macular degeneration may also be caused by environmental factors, aging and a genetic predisposition.
When animal models with macular degeneration were injected with induced neural progenitor stem cells, which derive from the more commonly known induced pluripotent stem cells, healthy cells began to migrate around the retina and formed a protective layer. This protective layer prevented ongoing degeneration of the vital retinal cells responsible for vision.
Cedars-Sinai researchers in the Induced Pluripotent Stem Cell (iPSC) Core, directed by Dhruv Sareen, PhD, with support from the David and Janet Polak Foundation Stem Cell Core Laboratory, first converted adult human skin cells into powerful induced pluripotent stem cells (iPSC), which can be expanded indefinitely and then made into any cell of the human body. In this study, these induced pluripotent stem cells were then directed toward a neural progenitor cell fate, known as induced neural progenitor stem cells, or iNPCs.
“These induced neural progenitor stem cells are a novel source of adult-derived cells which should have powerful effects on slowing down vision loss associated with macular degeneration,” said Clive Svendsen, PhD, director of the Board of Governors Regenerative Medicine Institute and contributing author to the study. “Though additional pre-clinical data is needed, our institute is close to a time when we can offer adult stem cells as a promising source for personalized therapies for this and other human diseases.”
The Latest on: Age-Related Macular Degeneration
[google_news title=”” keyword=”Age-Related Macular Degeneration” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Age-Related Macular Degeneration
- Neovascular Age-Related Macular Degenerationon September 27, 2023 at 5:00 pm
Randomized, controlled clinical trials have demonstrated the value of laser photocoagulation and photodynamic therapy with verteporfin in selected patients with neovascular age-related macular ...
- UNITY Biotechnology Announces 48-Week Results from Phase 2 ENVISION Study of UBX1325 in Patients with Wet Age-Related Macular Degenerationon September 27, 2023 at 4:05 am
today announced results from Part B of the Phase 2 ENVISION study of UBX1325 in patients with wet age-related macular degeneration (AMD) who were not achieving optimum benefit with their ongoing ...
- Neovascular Age-related Macular Degeneration and anti-VEGF Nonresponderson September 24, 2023 at 5:00 pm
Neovascular age-related macular degeneration is responsible for the overwhelming majority of vision loss in age-related macular degeneration. Not too long ago, the disease was poorly controlled ...
- Age Related Macular Degeneration (AMD) Market 2023-2031 Market Insight: by Market Dynamics and Growth Rate | with 101 Pageson September 20, 2023 at 9:38 pm
This in-depth market research offers a thorough analysis of the global "Age Related Macular Degeneration (AMD) Market" as it is referred to in 101 of Pages, including industry size, market share ...
- 2023 Wet Age Related Macular Degeneration (AMD) Market Is Booming Globally Forecast 2030 | Report Pages 113on September 18, 2023 at 11:02 pm
Recently Updated comprehensive113-Page Reporton the Wet Age Related Macular Degeneration (AMD) Market, this analysis deep dives into market size, share, and industry trends. According to our ...
- Complement C3 Variant and the Risk of Age-Related Macular Degenerationon September 13, 2023 at 5:01 pm
Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors. Complement activation ...
- From hagfish to membrane: Modeling age-related macular degenerationon September 13, 2023 at 11:41 am
Researchers at Utah State University have successfully demonstrated that hagfish slime proteins can accurately replicate membranes in the human eye.
- From hagfish to membrane: Modeling age-related macular degenerationon September 12, 2023 at 5:00 pm
Professor Elizabeth Vargis and her team study a condition called age-related macular degeneration that causes damage to the retina, making it difficult to see. They study in vitro models ...
- Can Machine Learning Detect Age-Related Macular Degeneration?on September 4, 2023 at 5:00 pm
A research team from National Cheng Kung University (NCKU), led by Chih-Chung Hsu, an assistant professor at the Institute of Data Science, NCKU, has demonstrated that machine learning can assist in ...
- What is macular degeneration?on September 2, 2023 at 7:49 pm
Age-related macular degeneration is the No. 1 cause of vision loss for adults over 50. It may run in families but not always, so a routine screening is recommended for most people as they get older.
via Bing News