Masson’s trichrome staining: the cell nuclei are blue-black, the cytoplasms (cell bodies) are mauve and the collagen fibers are green.
Credit: Riccardo Di Corato – laboratoire MSC (CNRS/Université Paris Diderot)
By combining, in a liposome, magnetic nanoparticles and photosensitizers that are simultaneously and remotely activated by external physical stimuli (a magnetic field and light), scientists obtained total tumor regression in mice.
Non-toxic when they are not activated, such therapies can also achieve a reduction in adverse effects. These results demonstrate the importance of multiple treatments.
One of the strategies employed to limit the adverse effects of cancer therapies is the development of nanocarrier systems that can convey active ingredients to target tumor cells. These are referred to as “physical” therapies when the active substances, molecules or nanoparticles, can be remotely activated by external physical stimuli — in this case by light or a magnetic field. In this context, the study team developed a new type of carrier that combines photosensitivity and magnetism. To achieve this, they first encapsulated magnetic nanoparticles in the inner compartment of a liposome in sufficient quantities to render it ultra-magnetic, before incorporating photosensitizers into its lipid bilayer, while preserving an optimum size for circulation in the blood.
These liposomes, containing magnetic nanoparticles and photosensitizers, were injected directly into the tumor in the mouse model. The scientists thus combined two techniques to achieve complete destruction of cancer cells. The first one, magnetic hyperthermia, consists in exciting the nanoparticles with a magnetic field to raise the temperature of the tumor and destroy it.. The second method, photodynamic therapy, is made possible by the photosensitizers, which, when activated, release reactive oxygen species that are toxic to tumor cells. These two physical therapies act in synergy on the activity of the proteins involved in apoptosis, or programmed cell death. Their combination thus induces total regression of the tumor, while a single therapy is not able to stop its growth.
Read more: Combining magnetism and light to fight cancer
The Latest on: Tumor regression
via Google News
The Latest on: Tumor regression
- Preoperative prediction of perineural invasion with multi-modality radiomics in rectal canceron May 3, 2021 at 12:28 pm
Perineural invasion (PNI) as a grossly underreported independent risk predictor in rectal cancer is hard to identify preoperatively. We aim to predict PNI status in rectal cancer using multi-modality ...
- Race and prostate specific antigen surveillance testing and monitoring 5-years after definitive therapy for localized prostate canceron May 3, 2021 at 12:06 pm
Prostate-specific antigen (PSA) surveillance testing is a cornerstone of prostate cancer survivorship because patients with biochemical recurrence often have no symptoms. However, the investigation of ...
- Effect of COVID-19 on breast cancer treatment examinedon May 3, 2021 at 9:19 am
(HealthDay)—More patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2-negative breast cancer have been treated with neoadjuvant endocrine therapy (NET) due to ...
- PDS Biotech Advances the Fight Against Cancer with its Versamune® Platformon May 3, 2021 at 7:01 am
PDS Biotechnology Corporation (NASDAQ: $PDSB) will be reporting preliminary Phase 2 clinical data of its lead compound PDS0101 for the treatment of advanced HPV-associated ...
- Performance assessment of the metastatic spinal tumor frailty index using machine learning algorithms: limitations and future directions.on May 2, 2021 at 10:55 pm
Frailty is recognized as an important consideration in patients with cancer who are undergoing therapies, including spine surgery. The definition of frailty in the context of spinal metastases is ...
- Personalised follow-up care needed to address varying health burdens in breast cancer ptson May 2, 2021 at 9:00 pm
A study presented at the ESMO Breast Cancer 2021 Virtual Congress has shown that breast cancer survivors differ widely in the burden of symptoms they experience after the end of treatment and thereby ...
- These mutant cacti suggest that there are better ways to battle canceron May 2, 2021 at 4:00 am
A garden of unusual-looking desert plants has been assembled to remind us that the most aggressive fight isn’t always best.
- Targeted treatments for small-cell lung canceron April 27, 2021 at 8:12 am
A rapid screening process identified a two-drug combination that shrank small-cell lung tumors, which are often fatal within weeks of recurrence.
- Using estrogen to target drug-resistant breast cancer in miceon April 25, 2021 at 10:26 pm
Hitchcock's Norris Cotton Cancer Center (NCCC) hope to make estrogen therapy a more accessible treatment option for breast cancer patients who could benefit from it.
- Targeting drug-resistant breast cancer with estrogenon April 24, 2021 at 3:27 am
Hitchcock's Norris Cotton Cancer Center (NCCC) hope to make estrogen therapy a more accessible treatment option for breast cancer patients who could benefit from it. Anti-estrogen treatments, which ...
via Bing News
