Many potentially efficient drugs have been created to treat neurological disorders, but they cannot be used in practice.
Typically, for a condition such as epilepsy, it is essential to act at exactly the right time and place in the brain. For this reason, the team of researchers led by Christophe Bernard at Inserm Unit 1106, “Institute of Systems Neuroscience” (INS), with the help of scientists at the École des Mines de Saint-Étienne and Linköping University (Sweden) have developed an organic electronic micropump which, when combined with an anticonvulsant drug, enables localised inhibition of epileptic seizure in brain tissue in vitro. This research is published in the journal Advanced Materials.
Drugs constitute the most widely used approach for treating brain disorders. However, many promising drugs failed during clinical testing for several reasons:
- they are diluted in potentially toxic solutions,
- they may themselves be toxic when they reach organs to which they were not initially directed,
- the blood-brain barrier, which separates the brain from the blood circulation, prevents most drugs from reaching their targets in the brain,
- drugs that succeed in penetrating the brain will act in a non-specific manner, i.e. on healthy regions of the brain, altering their functions.
Epilepsy is a typical example of a condition for which many drugs could not be commercialised because of their harmful effects, when they might have been effective for treating patients resistant to conventional treatments .
During an epileptic seizure, the nerve cells in a specific area of the brain are suddenly activated in an excessive manner. How can this phenomenon be controlled without affecting healthy brain regions? To answer this question, Christophe Bernard’s team, in collaboration with a team led by George Malliaras at the Georges Charpak-Provence Campus of the École des Mines of Saint-Étienne and Swedish scientists led by Magnus Berggren from Linköping University, have developed a biocompatible micropump that makes it possible to deliver therapeutic substances directly to the relevant areas of the brain.
The micropump (20 times thinner than a hair) is composed of a membrane known as “cation exchange,” i.e., it has negative ions attached to its surface. It thus attracts small positively charged molecules, whether these are ions or drugs. When an electrical current is applied to it, the flow of electrons generated projects the molecules of interest toward the target area.
The Latest on: Drug delivery system
[google_news title=”” keyword=”Drug delivery system” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Drug delivery system
- Nanotechnology in Therapeuticson February 21, 2024 at 4:00 pm
Nanomedicine. 2012;7(8):1253-1271. Liposomes Liposomes are self-assembled artificial vesicles developed from amphiphilic phospholipids. These vesicles consist of a spherical bilayer structure ...
- Researchers design novel drug delivery system that could reverse Alzheimer's disease impacton February 21, 2024 at 2:22 pm
University of North Carolina at Chapel Hill researchers have developed a new drug delivery platform that harnesses helical amyloid fibers designed to untwist and release drugs in response to body ...
- Patient feedback is creating next-gen drug delivery deviceson February 20, 2024 at 5:04 am
The patient voice has grown in importance, and now it is being applied to develop and deliver more sophisticated drug delivery devices. Ben Hargreaves finds that connected devices can now provide ...
- UCF Researcher Innovates Nanotechnologies for Sustainable Agriculture and Enhanced Drug Delivery Systemson February 19, 2024 at 10:27 pm
Prolific University of Central Florida inventor Swadeshmukul Santra is developing new technologies that hold promise not only for sustainable agriculture, but also for improved medicine.Santra, a prof ...
- Liposomal and Lipid Drug Delivery Systems Market Analysis With Top Key Players, Applications, And Trends During The Forecast Periodon February 19, 2024 at 4:21 am
According to a new report published by ResearchVise, the global Liposomal and Lipid Drug Delivery Systems market has witnessed significant growth in the recent past and is expected to register robust ...
- Global Advanced Drug Delivery Systems Markets and Technologies Report 2024, with Compound Annual Growth Projections Through 2028on February 19, 2024 at 1:29 am
The "Global Markets and Technologies for Advanced Drug Delivery Systems" report has been added to ResearchAndMarkets.com's offering. The global market for advanced drug delivery systems was valued at ...
- Silo Pharma’s SP-26 Ketamine Implant Demonstrates Successful Drug Deliveryon February 14, 2024 at 6:45 am
Initial indications target fibromyalgia and chronic painLoaded and encapsulated drug maintains structural stability as implantable ...
- Gastro-retentive Drug Delivery Systems Market Targets US$ 24.8 Billion by 2033on February 11, 2024 at 11:17 pm
Gastro-retentive Drug Delivery Systems MarketAccording to a recently released Future Market Insights study, the gastro-retentive drug delivery systems market revenue is expected to generate sales of ...
- Self-nanoemulsifying Drug Delivery Systems: Formulation Insights, Applications and Advanceson February 11, 2024 at 3:59 pm
Nanoemulsions can have long-term colloidal stability when fabricated using optimum conditions. Owing to this property, nanoemulsions can be used as drug carriers and can impart long shelf-life to ...
- Researchers develop nanofiber-based drug delivery system for skin canceron January 23, 2024 at 4:00 pm
Accordingly, the integration of nanofibers with on-demand drug delivery systems can open up new possibilities for drug therapy." More information: Baljinder Singh et al, Light-responsive layer-by ...
via Bing News