A team of University of Rhode Island engineers led by Professor Mohammad Faghri has created a new paper-based platform for conducting a wide range of complex medical diagnostics.
The key development was the invention of fluid actuated valves embedded in the paper that allow for sequential manipulation of sample fluids and multiple reagents in a controlled manner to perform complex multi-step immune-detection tests without human intervention.
Faghri said that the platform technology can potentially be applied to a wide variety of medical diagnostics, from Lyme disease and HIV to Ebola and malaria. “If someone comes up with a new biomarker for detecting a disease, we can create a test for it using our platform,” he said. He also envisions applications in the veterinary medicine field, as well as for the detection of environmental contaminants and biological or chemical threats. “It could even be used at airports to test fluids for possible bioterror agents,” he added.
A number of companies have already expressed interest in adapting various applications to the new platform. A strong patent with broad claims has been issued by the U.S. Patent and Trademark Office for this technology, and two more are pending.
According to Faghri, paper-based lateral flow test strips, such as for pregnancy tests, have been commercially successful for many years. In these devices, a sample fluid wicks along a strip of paper, reacts with embedded reagents, and produces a colored signal result. However, more complex medical diagnostics such as enzymatic assay protocols require multiple reagents triggered at particular times during the process, which can only be accomplished autonomously using the proprietary microfluidic valve technology created by the URI research team.
“We combined the well-established test strip technology, micro-patterning techniques and our innovative paper-based valves to create a new class of strip tests that are capable of autonomously handling multiple reagents,” explained Faghri. “The sample fluid activates the flow of reagents in a predetermined sequence and time. When combined with an optical reader, which could even be a conventional smart phone, the lab-on-paper device provides accurate quantitative results.
“We’re the only research group in the world to have created fluidic valves on multi-layered paper without the use of external mechanical, electric or magnetic force and to use these valves to create fluidic circuits similar to electrical circuits,” he added.
The lab-on-paper devices are constructed with multiple layers of paper printed with wax to create a three-dimensional structure of valves and channels along which the fluid travels, triggering the reagents at the appropriate time and generating a result.
This new paper-based technology is the next generation of the lab-on-a-chip device the research team reported in 2011, which has been further refined since then. That device is now smaller and employs an innovative micropump for precise fluid movement within the cartridge’s microchannels. “Our new paper-based system, however, doesn’t need any pumping because the fluid flows naturally along the paper channels via wicking,” said Faghri. “It can perform enzymatic assays on paper autonomously with sensitivities close to laboratory techniques.”
The Latest on: Lab-on-paper
via Google News
The Latest on: Lab-on-paper
- Why ‘Batgirl’ Proves That Filmmakers Shouldn’t Be Hollywood Lab Rats (Column)on August 6, 2022 at 3:00 am
This isn’t the first time that HBO scrapped the work of its creators, but filmmakers should view all studio experiments with caution.
- State forensic science panel pulls accreditation of Texas lab after finding shoddy workon August 5, 2022 at 9:06 pm
The Texas Forensic Science Commission has withdrawn its accreditation of a Houston-area toxicology lab used by prosecutors nationwide for more than 25 ...
- From the Navy to a neuroscience lab: how a daughter’s diagnosis spurred her mother’s career shifton August 5, 2022 at 1:40 am
After enlisting in the Navy straight out of high school, Carina Block is now a postdoctoral researcher at Duke, a place she never pictured herself ending up.
- How Peter Stout Turned Around Houston’s Crime Labon August 3, 2022 at 6:00 am
Peter Stout’s buoyant presence cuts a sharp contrast to his grisly work as head of the. Defying the typical laboratory white, Stout is dressed in ...
- “A coordinated regulatory dance”: Levine lab identifies new elements involved in genome organizationon August 2, 2022 at 8:21 pm
Levine’s team’s work could have critical implications in treating a host of human diseases, from psychiatric disorders to cancer and diabetes.
- Missing Minnesota Lab Mix Found Safe After Almost a Month Lost in the Wildernesson August 2, 2022 at 1:31 pm
A dog lost in the wilderness for several weeks is back with his owners. According to The Minneapolis Star Tribune, Luigi, a Labrador retriever mix, went missing on June 25 in Minnesota's Boundary ...
- F&S Bullet Lab: We Test the 6.5 Creedmoor Remington Core-Lokt Tippedon August 2, 2022 at 1:16 pm
We tested Remington's new Core-Lokt Tipped bullet in 6.5 Creedmoor by firing it into Clear Ballistics gel. Here are the results.
- The rise and fall of the lab leak hypothesis for the origin of SARS-CoV-2on August 1, 2022 at 12:01 am
Two new studies were published last week that strongly support a natural zoonotic origin for COVID-19 centered at the wet market in Wuhan, China. Naturally, lab leak proponents soberly considered this ...
- The zombie lab leak ‘theory’ sees human responsibility for COVID in all the wrong placeson July 31, 2022 at 4:00 am
The determination to imbue the virus’ origins with human agency curiously coexists with our will to ignore our role in its perpetuation. | Opinion ...
- ‘A super unique setup’: WMU lab leads the way on compost testingon July 31, 2022 at 2:00 am
By composting more food and food-tainted paper products, people can sharply cut the amount of methane produced in landfills.
via Bing News