Scientists who have discovered the mechanism of a protein that suppresses inflammation in the body, say the information could potentially be used to develop new drugs to control inflammation.
The international study, led by a husband-and-wife team, Associate Professor Marcel Nold and Dr Claudia Nold from The Ritchie Centre at MIMR-PHI Institute of Medical Research and Monash University, focused on interleukin 37 (IL-37), a powerful inhibitor of inflammation that is generated by the body.
Previous research by the same team identified that IL-37, one of the rare anti-inflammatory mediators, acts much more broadly than others to regulate the immune response and protect the body from damage.
The new study, published in Nature Immunology, deciphers the mechanisms of how the body uses IL-37 as a molecular signal to regulate and control inflammation.
The team found that to achieve its protective effects, IL-37 utilises a set of very specific receptors on target cells. By binding to these receptors, IL-37 instructs those target cells to execute a cascade of events, which temper several of the molecular pathways by which the body mounts inflammatory responses.
Associate Professor Marcel Nold said inflammation is a double-edged sword.
“We all need inflammation to protect us from the harmful effects of bacteria, viruses or cancer. But in many diseases, there is too much inflammation; good examples are stroke, heart attack and auto immune diseases such as Crohn’s Disease or lupus,” he said.
“Rampant inflammation is harmful and leads to tissue damage, resulting in all kinds of side effects like pain, fatigue and regrettably also organ failure and death” Associate Professor Nold said.
Dr Claudia Nold said the study is universally applicable to all types of inflammation in patients of all ages, in conditions ranging from the common cold to serious life-threatening illnesses.
“IL-37 is able to override the body’s own destructive responses to injury and disease, harnessing its fundamental mechanisms of action,” she said.
Read more: Scientists override the body’s inflammatory response
The Latest on: Inflammation
[google_news title=”” keyword=”Inflammation” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Inflammation
- Potential Drug Target Identified for Infection, Inflammation and Hemolytic Diseaseson June 5, 2023 at 2:04 am
Researchers have found a key ‘on’ switch, called NLRP12, for innate immune cell death in diseases that cause red blood cells to rupture, which can lead to inflammation and multi-organ failure.
- Red Sox Place Chris Sale On Injured List With Shoulder Inflammationon June 2, 2023 at 7:58 pm
The Red Sox have placed starter Chris Sale on the 15-day injured list due to inflammation in his throwing shoulder. Corey Kluber ...
- Red Sox’ Chris Sale goes on IL with left shoulder inflammation: ‘I hate feeling like this’on June 2, 2023 at 5:24 pm
" I started having fun playing baseball again, and now I’m back to not having fun. And that sucks,” Sale said.
- 17 High-Protein Snacks to Help Reduce Inflammationon June 2, 2023 at 7:47 am
Recipes like our Pizza Pistachios and Easy Black Bean Dip are tasty and healthy snacks you have to try. This tuna spread recipe is a healthy twist on tuna salad and uses avocado and Greek yogurt in ...
- 3 Unexpected Foods You Didn’t Know Could Relieve Inflammation And Chronic Painon June 2, 2023 at 4:00 am
If you’re experiencing inflammation and chronic pain, there are several factors that could be contributing to the issue, including diseases and psychological stress. Luckily, there are several ways ...
- 5 Best CBD Oil for Pain & Inflammation: 2023 Updateon June 1, 2023 at 10:00 pm
We may receive a commission for purchases made through these links. Fortunately for patients living with chronic pain and inflammation, CBD oil is finally getting the recognition it deserves as a ...
- 5 Best CBD Oil for Pain & Inflammation: 2023 Updateon June 1, 2023 at 10:00 pm
We may receive a commission for purchases made through these links. Fortunately for patients living with chronic pain and inflammation, CBD oil is finally getting the recognition it deserves as a ...
- NLRP12 as a new drug target for infection, inflammation and hemolytic diseaseson June 1, 2023 at 10:55 am
Infections and other diseases can cause red blood cells to rupture, releasing the oxygen-binding molecule hemoglobin, which breaks down into heme. Free heme can cause significant inflammation and ...
- Haims: Neurodegenerative diseases and inflammationon May 29, 2023 at 1:44 pm
Two of the most common neurodegenerative diseases are Alzheimer’s disease and Parkinson’s disease. Not only here in the United States, but also globally, these progressive debilitating diseases pose ...
via Bing News