3-D engineered bone marrow makes functioning platelets

A team led by researchers at the Tufts University School of Engineering and the University of Pavia has reported development of the first three-dimensional tissue system that reproduces the complex structure and physiology of human bone marrow and successfully generates functional human platelets. Using a biomaterial matrix of porous silk, the new, scalable system is capable of producing platelets for future clinical use and also provides a laboratory tissue system to advance study of blood platelet diseases. Shown above are platelet-producing blood cells called megakaryocytes (blue) releasing filament-like
CREDIT
Courtesy Tufts University

Scalable model supports patient-specific treatments, advanced study of blood disorders

A team led by researchers at Tufts University School of Engineering and the University of Pavia has reported development of the first three-dimensional tissue system that reproduces the complex structure and physiology of human bone marrow and successfully generates functional human platelets. Using a biomaterial matrix of porous silk, the new system is capable of producing platelets for future clinical use and also provides a laboratory tissue system to advance study of blood platelet diseases.

“There are many diseases where platelet production or function is impaired,” says Alessandra Balduini, M.D., research associate professor in the Department of Biomedical Engineering at Tufts, associate professor at the Department of Molecular Medicine at the University of Pavia and co-corresponding author on the paper. “New insight into the formation of platelets would have a major impact on patients and healthcare. In this tissue system, we can culture patient-derived megakaryocytes — the bone marrow cells that make platelets — and also endothelial cells, which are found in bone marrow and promote platelet production, to design patient-specific drug administration regimes.”

The new system can also provide an in vitro laboratory tissue system with which to study mechanisms of blood disease and to predict efficacy of new drugs–providing a more precise and less costly alternative to in vivo animal models.

The Latest on: 3D tissue system

via Google News

The Latest on: 3D tissue system

Stem cell therapy could become cheaper and widely available
on August 1, 2022 at 4:16 pm
UTS researchers have developed a 3D printed system that could enable high quality, wide-scale stem cell production in Australia at a lower cost.
3D model of brain tumor environment could aid personalized treatment
on August 1, 2022 at 3:06 pm
Virginia Tech scientists at the Fralin Biomedical Research Institute at VTC have developed a novel 3D tissue-engineered model of the glioblastoma tumor microenvironment that can be used to learn why ...
How Deepmind’s AI decodes millions of proteins
on August 1, 2022 at 12:33 pm
Alphabet’s Deepmind Technologies recently released 3D predicted structures of over 200 million proteins. Generated by its AI system AlphaFold, it aims to help researchers enhance their understanding ...
Imaging Technology Illustrates the Migration Path of Neurons in Rett Syndrome
on August 1, 2022 at 9:10 am
With organoids to model initial development, scientists employed a developing microscopy technology to observe that new neurons struggled to attain their developmental goal.
Sentara Adds New Surgical System To Aid Breast Cancer Patients
on August 1, 2022 at 7:29 am
A new surgical system at Sentara Medical Center in Woodbridge will improve outcomes for breast cancer patients, the hospital said on Monday.
Advanced imaging reveals mired migration of neurons in Rett syndrome lab models
on July 29, 2022 at 9:59 am
Using an innovative microscopy method, scientists at The Picower Institute for Learning and Memory at MIT observed how newborn neurons struggle to reach their proper places in advanced human brain ...
3D Printing in Medical Applications Market Size Is Expected To CAGR of 14.28% from 2021 To 2027 | 109 Pages Report
on July 28, 2022 at 3:29 am
D Printing in Medical Applications Market Size Trend 2022, Analysis, growth, share, Status and Forecast 2027 | 109 Pages ...
Curi Bio Launches Mantarray™ Platform – 3D Engineered Muscle Tissues for Discovery of New Therapeutics
on July 27, 2022 at 6:12 am
3D Mantarray tissue models will also be compatible with Curi’s new Nautilus system (optical mapping system for voltage and calcium analysis). Additionally, Curi offers services and partnerships ...
Curi Bio Launches Mantarray™ Platform – 3D Engineered Muscle Tissues for Discovery of New Therapeutics
on July 27, 2022 at 6:00 am
Curi Bio, a leading developer of human stem cell-based platforms for drug discovery, today announced the commercial launch of the Mantarray™ platform for human-relevant 3D heart and skeletal ...
3D Bioprinting Market worth $3.3 billion by 2027 – Exclusive Report by MarketsandMarkets™
on July 25, 2022 at 7:09 am
D Bioprinting Market is projected to USD 3.3 billion by 2027 from USD 1.3 billion in 2022, at a CAGR of 20.8% between 2022 and 2027, according to a new report by ™. Factors such as technological ...