CNPMicrocapsule
via Queen Mary University of London
A new ‘microcapsule’ treatment delivery method developed by researchers at Queen Mary University of London (QMUL) could reduce inflammation in cartilage affected by osteoarthritis and reverse damage to tissue.
The research was funded by Arthritis Research UK and the AO Foundation.
A protein molecule called C-type natriuretic peptide (CNP), which occurs naturally in the body, is known to reduce inflammation and aid in the repair of damaged tissue. However, CNP cannot be used to treat osteoarthritis in patients because it cannot target the damaged area even when the protein is injected into the cartilage tissue. This is because CNP is easily broken down and cannot reach the diseased site.
The researchers constructed tiny microcapsules, just 2 microns in diameter, with individual layers containing CNP that could release the protein slowly and therefore deliver the treatment in the most effective way.
In experiments on samples of cartilage taken from animals, they showed that the microcapsules could deliver the anti-inflammatory CNP in a highly effective way. The researchers believe that injections of microcapsules could in the future be used to heal damaged cartilage in people with osteoarthritis. The injections could be delivered easily by a GP.
Dr Tina Chowdhury from QMUL’s School of Engineering and Materials Science, who leads the research, said:
“If this method can be transferred to patients it could drastically slow the progression of osteoarthritis and even begin to repair damaged tissue.
“CNP is currently available to treat other conditions such as skeletal diseases and cardiovascular repair. If we could design simple injections using the microcapsules, this means the technology has the potential to be an effective and relatively cheap treatment that could be delivered in the clinic or at home.”
Read more here: New ‘microcapsules’ have potential to repair damage caused by osteoarthritis
The Latest on: Microcapsules
via Google News
The Latest on: Microcapsules
- Biodegradable microcapsules guide neuronal development by delivering nerve growth factoron February 21, 2021 at 9:36 am
These microcapsules play a critical role in nerve growth factor, a peptide that is necessary for neuron growth. The findings of the study were published in the journal Pharmaceutics.
- Biodegradable microcapsules guide neuronal developmenton February 21, 2021 at 5:10 am
Researchers from Skoltech and their colleagues have demonstrated that nanoengineered biodegradable microcapsules can guide the development of hippocampal neuron ...
- Biodegradable microcapsules guide neuronal development by delivering nerve growth factoron February 21, 2021 at 4:56 am
Researchers from Skoltech and their colleagues have demonstrated that nanoengineered biodegradable microcapsules can guide the development of hippocampal neurons in an in-vitro experiment.
- Biodegradable microcapsules guide neuronal development by delivering nerve growth factoron February 21, 2021 at 2:06 am
Researchers from Skoltech and their colleagues have demonstrated that nanoengineered biodegradable microcapsules can guide the development of hippocampal neurons in an in-vitro experiment. These ...
- Microcapsule Market by Technology, End-use Industry, Shell Material, Core Material, and Region – Global Forecast to 2025on February 17, 2021 at 8:24 pm
According to the new market research report “Microcapsule Market By Shell Material (Melamine, Non-Melamine), Core Material (Agricultural Inputs, Food Additives, Pharmaceutical ...
- Biodegradable microcapsules provide nerve growth factor helpful in guiding neuronal developmenton February 17, 2021 at 8:32 am
The microcapsules deliver nerve growth factor, a peptide necessary for neuron growth. The paper describing this work was published in the journal Pharmaceutics and the study was conducted by ...
- Biodegradable microcapsules provide nerve growth factoron February 17, 2021 at 3:53 am
Researchers during a recent study demonstrated that the development of hippocampal neurons in a vitro experiment can be guided by nanoengineered biodegradable m ...
- Biodegradable microcapsules deliver nerve growth factor to guide neuronal developmenton February 16, 2021 at 11:04 am
Researchers from Skoltech and their colleagues have demonstrated that nanoengineered biodegradable microcapsules can guide the development of hippocampal neurons in an in vitro experiment.
- Nanoengineered microcapsules deliver nerve growth factor to guide neuronal developmenton February 16, 2021 at 2:36 am
Researchers have demonstrated that nanoengineered biodegradable microcapsules can guide the development of hippocampal neurons in an in vitro experiment. The microcapsules deliver nerve growth factor, ...
via Bing News
