Researchers could be closing in on a “fountain of youth” drug that can delay the effects of aging and improve the health of older adults, a new study suggests
Seniors received a significant boost to their immune systems when given a drug that targets a genetic signaling pathway linked to aging and immune function, researchers with the drug maker Novartis report.
The experimental medication, a version of the drug rapamycin, improved the seniors’ immune response to a flu vaccine by 20 percent, researchers said in the current issue of Science Translational Medicine.
The study is a “watershed” moment for research into the health effects of aging, said Dr. Nir Barzilai, director of the Institute for Aging Research at Albert Einstein College of Medicine in New York City.
Rapamycin belongs to a class of drugs known as mTOR inhibitors, which have been shown to counteract aging and aging-related diseases in mice and other animals.
Barzilai, who wasn’t involved in the study, said this is one of the first studies to show that these drugs also can delay the effects of aging in humans.
“It sets the stage for using this drug to target aging, to improve everything about aging,” Barzilai said. “That’s really going to be for us a turning point in research, and we are very excited.”
The mTOR genetic pathway promotes healthy growth in the young. But it appears to have a negative effect on mammals as they grow older, said study lead author Dr. Joan Mannick, executive director of the New Indications Discovery Unit at the Novartis Institutes for Biomedical Research.
When drugs like rapamycin are used to inhibit the effects of the mTOR pathway in mice, they “seem to extend lifespan and delay the onset of aging-related illnesses,” Mannick said.
Mannick and her colleagues decided to investigate whether a rapamycin-like drug could reverse the natural decline that elderly people experience in their ability to fight off infections.
In the clinical trial, more than 200 people age 65 and older randomly received either the experimental drug or a placebo for several weeks, followed by a dose of flu vaccine.
Flu is particularly hard on seniors, with people 65 and older accounting for nine out of 10 influenza-related deaths in the United States, according to background information provided by the researchers.
Those who received the experimental version of rapamycin developed about 20 percent more antibodies in response to the flu vaccine, researchers found. Even low doses of the medication produced an improved immune response.
The researchers also found that the group given the drug generally had fewer white blood cells associated with age-related immune decline.
Mannick called this study the “first baby step,” and was reluctant to say whether it could lead to immune-boosting medications for the elderly.
The Latest on: Anti-aging drug
[google_news title=”” keyword=”Anti-aging drug” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Anti-aging drug
- How Anti-Aging Hackers May Advance Serious Scienceon February 21, 2024 at 11:00 pm
They include off-label use of generic drugs such as diabetes med metformin and immune-system ... indicate that the rapamycin may help slow or even reverse some aspects of aging on the cellular level.
- Repair aging knees, through the nose — and moreon February 21, 2024 at 9:47 am
German researchers at the University Hospital Wurzburg regenerated cartilage from the nose to the knee. First, they took a small piece of cartilage from the nasal septum and grew it in the lab on a ...
- My anti-aging routine will help reduce your jiggly jowls – the sound effects I like to do are optionalon February 19, 2024 at 6:13 am
FOR a beauty pro, aging gracefully is the goal; for some added fun, she also likes to make a few noises while doing her routine. The anti-aging expert said her tips minimize sagging skin and fine ...
- Anti-Aging Drug For Dogs Createdon February 19, 2024 at 1:55 am
The first anti-aging drug designed specifically for dogs has entered clinical trials in a groundbreaking development. The drug is developed by San Francisco-based startup Loyal. Thus, this ...
- South Korea’s ‘Alchemist Project’: Advancing in Revolutionary Technologies Including Anti-Aging Drugson February 14, 2024 at 11:26 pm
South Korea’s Ministry of Trade, Industry, and Energy has announced the advancement of three groundbreaking research projects into the main research phase under the ‘Alchemist Project,’ aimed at ...
- The next leap in pet health: longevity drugs for dogson February 14, 2024 at 6:00 am
Find out how we could stave off the heartbreak of saying goodbye to our dogs, as three longevity drugs for dogs could soon be approved.
- 9 Best Peptides For Anti Aging & Tightening Wrinkleson February 13, 2024 at 10:52 am
Anti-aging peptides have made huge strides over the last few years ... Here, you'll find countless people sharing about their experience using the "miracle drug." But does NAD+ combat the signs of ...
- A new anti-aging pill for senior dogs just entered clinical trials. Could it one day help humans live longer?on February 11, 2024 at 3:59 pm
A first-of-its-kind anti-aging drug for dogs that targets the metabolic fitness process has now entered clinical trials, and the scientists behind the chewable pill say it could lay the groundwork ...
- Anti-aging drugs could one day help pets live longeron February 7, 2024 at 5:34 am
Anti-aging drugs could one day help pets live longer Companies are investing millions in combating aging and mortality. But this phenomenon doesn't just concern humans. A series of startups are ...
via Bing News