A way to block a pain pathway in animal models of chronic neuropathic pain including pain caused by chemotherapeutic agents and bone cancer pain suggesting a promising new approach to pain relief.
In research published in the medical journal Brain, Saint Louis University researcher Daniela Salvemini, Ph.D. and colleagues within SLU, the National Institutes of Health (NIH) and other academic institutions have discovered a way to block a pain pathway in animal models of chronic neuropathic pain including pain caused by chemotherapeutic agents and bone cancer pain suggesting a promising new approach to pain relief.
The scientific efforts led by Salvemini, who is professor of pharmacological and physiological sciences at SLU, demonstrated that turning on a receptor in the brain and spinal cord counteracts chronic nerve pain in male and female rodents. Activating the A3 receptor – either by its native chemical stimulator, the small molecule adenosine, or by powerful synthetic small molecule drugs invented at the NIH – prevents or reverses pain that develops slowly from nerve damage without causing analgesic tolerance or intrinsic reward (unlike opioids).
An Unmet Medical Need
Pain is an enormous problem. As an unmet medical need, pain causes suffering and comes with a multi-billion dollar societal cost. Current treatments are problematic because they cause intolerable side effects, diminish quality of life and do not sufficiently quell pain.
The most successful pharmacological approaches for the treatment of chronic pain rely on certain “pathways”: circuits involving opioid, adrenergic, and calcium channels.
For the past decade, scientists have tried to take advantage of these known pathways – the series of interactions between molecular-level components that lead to pain. While adenosine had shown potential for pain-killing in humans, researchers had not yet successfully leveraged this particular pain pathway because the targeted receptors engaged many side effects.
A Key to Pain Relief
In this research, Salvemini and colleagues have demonstrated that activation of the A3 adenosine receptor subtype is key in mediating the pain relieving effects of adenosine.
“It has long been appreciated that harnessing the potent pain-killing effects of adenosine could provide a breakthrough step towards an effective treatment for chronic pain,” Salvemini said. “Our findings suggest that this goal may be achieved by focusing future work on the A3AR pathway, in particular, as its activation provides robust pain reduction across several types of pain.”
The Latest on: Pain relief
[google_news title=”” keyword=”Pain relief” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Pain relief
- Sharp Pain in Your Ear? Here's What Your Body's Trying to Tell Youon March 30, 2023 at 8:18 am
Ear pain from a sinus infection isn't usually sharp or stabbing, unless the infection is very severe. In that case, you should seek treatment ASAP, says Dr. Mehdzizadeh. Jaw discomfort or soreness ...
- Why Reviewers Swear By This $28 Tool For Back Pain Reliefon March 30, 2023 at 7:32 am
If you’ve ever woken up with annoying pain in your neck or back, you may benefit from using an acupressure mat to get some much-needed relief. There’s one you can get right now on Amazon that ...
- Revolutionary pain relief cream and two-minute exercise to cure and prevent lower back painon March 30, 2023 at 3:38 am
Dr Helene Bertrand explores her lower back pain journey and the ways she has found to heal herself in an interview ...
- Physical activity for pain relief in OA RA flare-upson March 30, 2023 at 3:12 am
Dr. Sharma discusses the importance and role of Physical activity in relieving pain in OA RA flare-ups ...
- Gender bias can affect women's medical treatment. Here's how you can advocate for yourselfon March 30, 2023 at 3:00 am
For many women, it's the same story. Something starts to feel off, you're experiencing a new physical pain, but when you go to a doctor for treatment, they can't pinpoint what's wrong. Some might ...
- Pulsed radiofrequency therapy may improve sciatica painon March 30, 2023 at 12:00 am
People suffering from sciatica gain lasting relief from a procedure that uses a fine needle to heat nerve roots near the spine, a new clinical trial shows.
- These Are the Best Medications for Low Back Pain, According to New Researchon March 29, 2023 at 9:41 am
Popular back pain medications like acetaminophen and muscle relaxers may not help lower back pain, a new study finds. Experts share alternative pain relief options.
- Swearing is helpful for pain reliefon March 29, 2023 at 6:00 am
Neuroscientists say that swearing is useful for relieving pain and have ranked the most effective curse words to use when in agony.
- Pain Relief Patches Market With New Statistical Report 2029on March 28, 2023 at 9:48 pm
Insights] “Pain Relief Patches Market” Size 2023 Key players Profiled in the Report are [Hisamitsu, Mylan, Johnson ...
- 12 Best Mattress Toppers for Back Pain Relief, According to Expertson March 27, 2023 at 2:40 pm
Thankfully, the best mattress toppers for back pain can be a convenient solution to alleviate your back stiffness—and ultimately help you sleep more comfortably. When it comes to shopping for the best ...
via Bing News