A team of scientists from Arizona State University’s Biodesign Institute and IBM’s T.J. Watson Research Center have developed a prototype DNA reader that could make whole genome profiling an everyday practice in medicine.
“Our goal is to put cheap, simple and powerful DNA and protein diagnostic devices into every single doctor’s office,” said Stuart Lindsay, an ASU physics professor and director of Biodesign’s Center for Single Molecule Biophysics. Such technology could help usher in the age of personalized medicine, where information from an individual’s complete DNA and protein profiles could be used to design treatments specific to their individual makeup.
Such game-changing technology is needed to make genome sequencing a reality. The current hurdle is to do so for less than $1,000, an amount for which insurance companies are more likely to provide reimbursement.
In their latest research breakthrough, the team fashioned a tiny, DNA reading device a thousands of times smaller than width of a single human hair.
The device is sensitive enough to distinguish the individual chemical bases of DNA (known by their abbreviated letters of A, C, T or G) when they are pumped past the reading head.
Proof-of-concept was demonstrated, by using solutions of the individual DNA bases, which gave clear signals sensitive enough to detect tiny amounts of DNA (nanomolar concentrations), even better than today’s state-of-the-art, so called next-generation DNA sequencing technology.
Making the solid-state device is just like making a sandwich, just with ultra high-tech semiconductor tools used to slice and stack the atomic-sized layers of meats and cheeses like the butcher shop’s block. The secret is to make slice and stack the layers just so, to turn the chemical information of the DNA into a change in the electrical signal.
First, they made a “sandwich” composed of two metal electrodes separated by a two-nanometer thick insulating layer (a single nanometer is 10,000 times smaller than a human hair), made by using a semiconductor technology called atomic layer deposition.
Then a hole is cut through the sandwich: DNA bases inside the hole are read as they pass the gap between the metal layers.
“The technology we’ve developed might just be the first big step in building a single-molecule sequencing device based on ordinary computer chip technology,” said Lindsay.
The Latest on: DNA sequencing
via Google News
The Latest on: DNA sequencing
- Clinical Oncology Next Generation Sequencing Global Market Report 2022on May 24, 2022 at 1:39 am
Major players in the clinical oncology next-generation sequencing market are Thermo Fisher Scientific (Qiagen), Oxford Nanopore Technologies, QIAGEN, Myriad Genetics, Illumina, F. Hoffmann-La Roche, ...
- CD Genomics Supercharges Transcriptomics Research by Digital RNA Sequencing Technologyon May 23, 2022 at 2:55 pm
CD Genomics is proud to launch the Digital RNA Sequencing technology, a next-generation sequencing-based method that eliminates sequence-dependent PCR ...
- Refurbished DNA Sequencing Platforms Market | North America expected registering a CAGR of 3.2% during forecast periodon May 20, 2022 at 6:15 am
North America offers profitable opportunities for key players operating in the refurbished DNA sequencing platforms market, thereby registering the ...
- DNA polymerase market register a revenue CAGR of 6.4% during the forecast period 2021-2031on May 20, 2022 at 5:46 am
According to the newest analysis by Reports and Data, the global DNA polymerase market is estimated to reach USD 568.3 million in 2030, with a revenue CAGR of 6.4 percent over the forecast period.
- Researchers show the feasibility of a comprehensive sequencing approach in pediatric and young adult cancerson May 18, 2022 at 7:10 am
New findings from researchers at Memorial Sloan Kettering Cancer Center (MSK) and published today in the journal Nature Communications report the results of using a comprehensive sequencing approach ...
- DNA Sequencing Market Size to Rise by USD 23.56 bn | 38% of the market growth to originate from North America| Technavioon May 16, 2022 at 5:20 pm
According to the latest market analysis report "DNA Sequencing Market by Solution and Geography - Forecast and Analysis 2022-2026", the market will witness ...
- Brain tumour treatment using DNA sequencing gives ‘hope’ for patientson May 13, 2022 at 4:11 am
Brain tumour patients are beginning to benefit from new personalised treatment using DNA sequencing, the NHS has said. Patients with glioblastoma, the most aggressive and fatal form of brain tumour, ...
- Probe of DNA repeats reveals genetic link to schizophreniaon May 11, 2022 at 5:00 pm
Researchers at The Hospital for Sick Children (SickKids) and Centre for Addiction and Mental Health (CAMH) have found that repeated DNA sequences in the genome may contribute to an individual's risk ...
- Whole-genome sequencing being done on samples from people returning from Indiaon May 10, 2022 at 7:15 pm
Whole-genome sequencing is a comprehensive method of analysing the entire DNA sequence of an organism’s genes. Researchers believe that whole-genome sequencing of coronavirus could be instrumental in ...
- Democratizing Genomics, Sequentify Raises $7M to Enable DNA Sequencing at Scaleon May 10, 2022 at 4:17 am
600% revenue growth rate, Sequentify supplies Next Generation Sequencing libraries and software for cancer diagnostics, carrier screening and COVID-19 surveillance Sequentify, on track to 600% revenue ...
via Bing News