The St Vincent’s Hospital Heart Lung Transplant Unit has carried out the world’s first distant procurement of hearts donated after circulatory death (DCD). These hearts were subsequently resuscitated and then successfully transplanted into patients with end-stage heart failure.
Transplant Units until now have relied solely on donor hearts from brain-dead patients whose hearts are still beating. The use of DCD hearts, where the heart is no longer beating, represents a paradigm shift in organ donation and will herald a major increase in the pool of available hearts for transplantation.
St Vincent’s has recently transplanted two patients using DCD hearts both of whom have recovered extremely well. The DCD transplants were carried out following pioneering basic and translational research undertaken by the Victor Chang Cardiac Research Institute and St Vincent’s Hospital, who have jointly developed a special preservation solution that together with the use of a novel portable console to house, resuscitate and transport donor hearts; has made this milestone achievable.
The ex vivo Organ Care System (OCS – TransmedicsTM) involves the Transplant retrieval team connecting the donor heart to a sterile circuit where it is kept beating and warm thereby limiting the detrimental effects of cold ischaemia (a period where the heart is dormant without oxygen and nutrients) that occurs with the standard organ preservation mode of packing the heart on ice in an Esky. Once housed inside the portable device, the heart is reanimated, preserved and able to be functionally assessed until it is ready to be placed inside the recipient.
Coined the “Heart in a box”, for the past several months the OCS has provided the transplant surgeons greater versatility with regard to both organ preservation and resuscitation. This has enabled the St Vincent’s Transplant Unit to conduct several regular heart transplants this year through more long distance organ retrievals and most importantly, retrieval of “marginal hearts”, that is, brain death hearts previously regarded as being unsuitable for transplantation.
This portable OCS technology will help significantly in mitigating the significant disparity that remains between the increasing number of patients with end-stage heart failure on the transplant waiting list and the number of suitable donor-hearts that are available. Whilst the use of DCD organs has already made an enormous positive impact on liver, kidney and lung transplantation, it has to date not been possible to use DCD hearts. This is the first time internationally that human heart transplantation has been achieved with hearts donated following circulatory death and procured at a distance with portable organ preservation technology.
The Latest on: End-stage heart failure
[google_news title=”” keyword=”end-stage heart failure” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: End-stage heart failure
- Cardiac Ultrasound Systems Market Primed for US$ 2.48 Billion Ascendancy, Riding a Steady 5% CAGR by 2033on February 21, 2024 at 8:43 pm
It is anticipated that the cardiac assist device market growth would grow at a stunning 6.1% CAGR to reach US$ 2.48 billion by 2033, surpassing US$ 1.37 billion by 2023. The Cardiac Assist Devices ...
- Children's hospital advocates to close the gap in pediatric heart careon February 21, 2024 at 8:09 am
However, there is a notable gap in device options for infants and young children with end stage heart failure. Although tools for the youngest heart patients are limited, the Ochsner Children's ...
- Heart Health: Everything To Know About Minimally Invasive Structural Interventionson February 21, 2024 at 5:03 am
There is a wide range of cardiac diseases such as valvular heart disease, congenital defects and heart failure that can be treated without doing the traditional open-heart surgery.
- Heart Pumps Market Forecasted to Achieve 18.3% CAGR, Surpassing USD 12.3 billion by 2031: Transparency Market Research, Inc.on February 21, 2024 at 1:36 am
The value of the heart pumps sector is also being driven by the global increase in heart care awareness.Wilmington, Delaware, United States, Feb. 21, 2024 (GLOBE NEWSWIRE) -- Transparency Market ...
- Bridging the gap in pediatric heart care with advanced deviceson February 20, 2024 at 7:16 pm
Ochsner Children's Hospital, ranked among the top hospitals in the nation for pediatric cardiology and congenital heart surgery, is raising awareness of the need for more pediatric-specific heart ...
- Fundraiser launched to help brave Cassidy in her final monthson February 18, 2024 at 4:00 pm
A FUNDRAISER has been launched to help a brave young woman with just months to live. Cassidy Ley, 19, of Ventnor, is in end stage heart failure with a prognosis of six to 12 months left to live, and ...
- Support Pours In For Western Mass Baby In Need Of Heart Transplanton February 16, 2024 at 10:25 am
Austin is now a patient at Boston Children's Hospital and needs a Berlin Heart Mechanical Heart to keep his little heart beating until a donor organ can be found. His parents' friends have stepped up ...
- Westminster Mom Has So Much Heart, She Donated a Kidney to Her Toddleron February 14, 2024 at 11:17 pm
When their son, Hank, was born with end stage kidney failure, Jessica and Steven Shockney of Westminster knew what they had to do.After watching him suffer on ...
- Organ donor's heart saves Minnesota baby born with rare genetic disorderon February 14, 2024 at 4:57 am
"Take it day by day and know that you can get to a really beautiful place on the other side if you can just hold on," said mom Jessie Smith.
- Genomic study sheds light on immune microenvironment in transplanted pediatric heartson February 13, 2024 at 4:00 am
Pediatric heart transplantation has long been hailed as a life-saving intervention for children suffering from end-stage heart failure. While the ...
via Bing News