Weizmann Institute researchers suggest that the brain’s “immunological age” is what counts
How the brain ages is still largely an open question – in part because this organ is mostly insulated from direct contact with other systems in the body, including the blood and immune systems. In research that was recently published in Science, Weizmann Institute researchers Prof. Michal Schwartz of the Neurobiology Department and Dr. Ido Amit of Immunology Department found evidence of a unique “signature” that may be the “missing link” between cognitive decline and aging. The scientists believe that this discovery may lead, in the future, to treatments that can slow or reverse cognitive decline in older people.
Until a decade ago, scientific dogma held that the blood-brain barrier prevents the blood-borne immune cells from attacking and destroying brain tissue. Yet in a long series of studies, Schwartz’s group had shown that the immune system actually plays an important role both in healing the brain after injury and in maintaining the brain’s normal functioning. They have found that this brain-immune interaction occurs across a barrier that is actually a unique interface within the brain’s territory.
This interface, known as the choroid plexus, is found in each of the brain’s four ventricles, and it separates the blood from the cerebrospinal fluid. Schwartz: “The choroid plexus acts as a ‘remote control’ for the immune system to affect brain activity. Biochemical ‘danger’ signals released from the brain are sensed through this interface; in turn, blood-borne immune cells assist by communicating with the choroid plexus.This cross-talk is important for preserving cognitive abilities and promoting the generation of new brain cells.”
This finding led Schwartz and her group to suggest that cognitive decline over the years may be connected not only to one’s “chronological age” but also to one’s “immunological age,” that is, changes in immune function over time might contribute to changes in brain function – not necessarily in step with the count of one’s years.
The Latest on: Aging in the Brain
[google_news title=”” keyword=”Aging in the Brain” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Aging in the Brain
- Your Organs Might Be Aging at Different Rateson December 6, 2023 at 9:46 am
It turns out that your chronological age really is just a number. What’s more important for knowing disease risk is the biological age of each of your organs ...
- Blood Test Can Reveal if You Are at Risk From Organs Aging Prematurelyon December 6, 2023 at 8:00 am
"We can estimate the biological age of an organ in an apparently healthy person" and predict "a person's risk for disease," a neurologist said.
- At 63, Valerie Bertinelli Gets Real About Aging: ‘Parts of My Body Are Sagging’on December 5, 2023 at 5:30 am
Valerie Bertinelli shared her thoughts on aging and how she says “parts of my body are sagging.” Fans shared their sentiments in the comments.
- CABHI Supports 22 Organizations with Adopting Innovation to Enhance the Lives of Older Adults Across Canadaon December 5, 2023 at 2:13 am
Up to $3.3 million in funding available to foster innovation in healthcare TORONTO, Dec. 5, 2023 /CNW/ - Addressing the evolving needs of older adults, the Centre for Aging + Brain Health Innovation ...
- Thomas Kraynak: How your brain ages, and some ways aging might be slowedon December 3, 2023 at 2:30 am
I wish I could have scanned my Grandma Kraynak’s brain before she died. Most people in their seventies and beyond tend to experience memory and other cognitive problems, or even develop dementia or ...
- CANADA MARKS 5TH ANNUAL WOMEN'S BRAIN HEALTH DAYon December 2, 2023 at 4:02 am
to raise awareness about brain-aging diseases and to raise funds for more research that better meets the unique needs of women. "With women's cognitive well-being a priority, Women's Brain Health ...
- This protein could be the key to turning back your brain’s aging clockon November 24, 2023 at 8:20 pm
Researchers at Mount Sinai have discovered how the protein TIMP2 affects the hippocampus, a brain area vital for memory and learning. Using advanced techniques in mutant mouse models, the team showed ...
- Killing 'Zombie' Cells Emerges As Key to Reversing Covid-Induced Brain Agingon November 24, 2023 at 8:09 pm
Scientists at the University of Queensland have made a significant breakthrough in their research on Covid-19's impact on brain health. Using synthetic brain organoid models grown in a laboratory ...
- How Menopause Changes the Brainon November 24, 2023 at 5:08 am
Across the U.S., roughly 6 million adults 65 and older have Alzheimer’s disease. Almost two-thirds of them are women — a discrepancy that researchers have long attributed to genetics and women’s ...
- Neuroscientists Kill 'Zombie' Cells to Reverse COVID Brain Agingon November 23, 2023 at 6:27 am
Infection with SARS-CoV-2 accelerates the rate of premature aging in the brain. But what if there was a way to turn back the clock?
via Bing News