Scientists have used computer simulations to show how bacteria are able to destroy antibiotics – a breakthrough which will help develop drugs which can effectively tackle infections in the future.
Researchers at the University of Bristol focused on the role of enzymes in the bacteria, which split the structure of the antibiotic and stop it working, making the bacteria resistant.
The new findings, published in Chemical Communications, show that it’s possible to test how enzymes react to certain antibiotics.
It’s hoped this insight will help scientists to develop new antibiotics with a much lower risk of resistance, and to choose the best medicines for specific outbreaks.
Using a Nobel Prize-winning technique called QM/MM – quantum mechanics/molecular mechanics simulations – the Bristol research team were able to gain a molecular-level insight into how enzymes called ‘beta-lactamases’ react to antibiotics.
Researchers specifically want to understand the growing resistance to carbapenems, which are known as the ‘last resort’ antibiotics for many bacterial infections and super bugs such as E. coli.
Resistance to carbapenems makes some bacterial infections untreatable, resulting in minor infections becoming very dangerous and potentially deadly.
The Latest on: Antibiotics
via Google News
The Latest on: Antibiotics
- Proteon Pharma to develop bacteriophages as a sustainable alternative to antibiotics in poultry industryon October 13, 2021 at 9:30 pm
Proteon Pharma to develop bacteriophages as a sustainable alternative to antibiotics in poultry industry: Our Bureau, Mumbai Thursday, October 14, 2021, 10:00 Hrs [IST] Proteon Ph ...
- Scientists suggest a new approach to mitigating the collateral damage from antibioticson October 13, 2021 at 7:21 pm
Antibiotics help us to treat bacterial infections and save millions of lives each year. But they can also harm the helpful microbes residing in our gut, weakening one of our body's first lines of ...
- Tackling the collateral damage from antibioticson October 13, 2021 at 8:10 am
Antibiotics help us to get rid of bacterial infections – but they can also harm the helpful microbes residing in our guts. Researchers from the Typas group at EMBL Heidelberg and collaborators have ...
- Some antibiotics may kill 'helpful' gut bacteria, study findson October 13, 2021 at 8:01 am
Tetracyclines and macrolides, two commonly used classes of antibiotics, stop beneficial gut bacteria from growing and ultimately kill them, a study published Wednesday by Nature found.
- Study probes link between antibiotics during pregnancy and allergieson October 13, 2021 at 1:46 am
Doctors are investigating whether increased use of antibiotics during pregnancy and childbirth could be contributing to the rise in allergies ...
- Does a 2-Day Course of Antibiotics Lower the Incidence of Ventilator-associated Pneumoniaon October 13, 2021 at 1:35 am
The purpose of this double-blind, randomized control trial was to see if a 2-day course of amoxicillin-clavulanate could reduce the incidence of early ventilator-associated pneumonia in patients ...
- Conversations in the Cath Lab: Do You Use Antibiotics?on October 12, 2021 at 12:05 pm
When—if ever—are antibiotics warranted before vascular closure devices are used? Turns out, opinions are mixed.
- Cardboard cuttings, no antibiotics and food on the floor: Nature Strip’s different Everest prepon October 12, 2021 at 10:25 am
Trainer Chris Waler says Nature Strip’s hay fever problem is now behind him as his coat has the winning sheen heading into The Everest.
- Proteon Pharma to focus on development of Bacteriophages as a sustainable alternative to antibiotics in poultry industryon October 12, 2021 at 7:00 am
Proteon Pharmaceuticals India - a subsidiary of Proteon Pharmaceuticals SA Poland, today announced it will focus on the development of bacteriophages as a sustainable alternative to ...
- Inhaled Antibiotics Market Report 2021 Size with Segments Analysis, Competitive Landscape, Top Countries Data and Growth Opportunities to 2027on October 4, 2021 at 11:06 pm
Global “Inhaled Antibiotics Market” Size, Status and Growth Forecast to 2027: The Inhaled Antibiotics Market report ...
via Bing News