A potential breakthrough in techniques to develop drugs to treat diseases as diverse as cancer and Alzheimer’s has been reported by chemists at the University of Leicester in the UK.
The Jamieson Research Group in the Department of Chemistry at the University of Leicester claim to have developed a new process for generating a specific synthetic amino acid.
Amino acids are used to make all proteins – the Leicester team refers to them as “Mother Nature’s building blocks,” as they are essential for life.
“We are very proud of this research,” says lead scientist Dr. Andrew Jamieson, “it has taken several years of hard work to master the chemistry techniques to create these new building blocks, but now that we have conquered it, we have access to new building blocks that people have only ever dreamed of before!”
There are 20 naturally produced amino acids in total. By contrast, the new chemical synthesis of unnatural amino acids pioneered by the Leicester team could be used to make designer mini-proteins with entirely new structures and functions from those found in nature.
Dr. Jamieson explains:
“Unnatural amino acids, the building blocks, are described as chiral, meaning they have ‘handedness.’ A robust synthesis to selectively produce molecules with a particular handedness has not previously been reported. Our new practical method allows us to selectively synthesize only the ‘right handed molecules.’
This new research is important because it has uncovered a new, easier and quicker way to make these building blocks which can be used to make new drugs. We now have access to new building blocks to develop innovative new protein drugs for the treatment of disease.”
Dr. Jamieson mentions that a student also used the building blocks to synthesize a toxin produced by a sea snail, which the team hopes to develop as a new painkiller.
The Latest on: Designer proteins
[google_news title=”” keyword=”Designer proteins” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Designer proteins
- Nanoparticle flu vaccine design shows promise in early testson December 8, 2023 at 6:41 am
Existing flu vaccines provide only limited, seasonal protection because they target highly changeable proteins on the virus. Scripps Research scientists have now designed a vaccine that should work ...
- Plant protein ecosystem partners address lentil concerns through new AI technologyon December 6, 2023 at 8:01 am
Today, a consortium of partners representing Canada’s agriculture and agrifood sectors are announcing a project to develop artificial intelligence technology to address some of the biggest issues ...
- Hard to drug: Protein droplets reveal new ways to inhibit transcription factors in an aggressive form of prostate canceron December 4, 2023 at 9:11 am
Transcription factors play essential roles in turning the genetic information encoded in genes into proteins in all cells and organisms. These regulatory proteins bind DNA, turn genes on or off, and ...
- 'We are gaining a better understanding’: Scientists uncover new method to stop lung cancer proteinon December 2, 2023 at 12:00 am
A new study has identified a protein which could lead to the development of new anti-cancer drugs. The research showed that a protein known to stop tumours called RBM10 can slow down the growth of ...
- Faculty to use AI for Protein Design and Discovery with Support of $1.8 Million NIH Granton November 29, 2023 at 4:00 am
The National Institute of Health (NIH) has awarded Yunan Luo a grant for more than $1.8 million to use artificial intelligence (AI) to advance protein research.
- Protein engineer AI start-up Cradle raises $24m in Series A funding roundon November 28, 2023 at 5:14 am
Biotech AI start-up Cradle has raised $24m (€21.92m) in its Series A funding round and secured partnerships with industry leaders in pharmaceuticals and chemicals. The investment was led by private ...
- Dutch-Swiss startup Cradle raises €21.9M for pioneering Generative AI in protein designon November 28, 2023 at 3:19 am
Amsterdam and Zurich-based Cradle, a biotech startup, has raised $24M (approximately €21.92M) in a Series A funding round. The company specialises in ...
- Google Alum's Biotech Startup Cradle Raises $24M To Boost AI-Powered Protein Design And Engineeringon November 28, 2023 at 2:10 am
Dutch biotech startup Cradle has raised $24 million in Series A funding as it looks to boost its protein design and engineering process.
- Cradle uses generative AI to design proteins more efficiently. See the 17-slide deck it used to secure $24 million from Index Ventures.on November 28, 2023 at 12:00 am
The Dutch startup's aim is to help scientists design proteins more quickly than the industry standard, with its AI-based software.
- Cradle's AI-powered protein programming platform levels up with $24M in new fundingon November 27, 2023 at 4:02 pm
Biotech and AI startup Cradle is finding success with its generative approach to protein design, landing big customers and a hefty $24 million of new investment. The company exited stealth a little ...
via Bing News