Human skeletal muscle tissue 1 – TEM (Photo credit: Wikipedia)
What if repairing large segments of damaged muscle tissue was as simple as mobilizing the body’s stem cells to the site of the injury?
New research in mice and rats, conducted at Wake Forest Baptist Medical Center’s Institute for Regenerative Medicine, suggests that “in body” regeneration of muscle tissue might be possible by harnessing the body’s natural healing powers.
Reporting online ahead of print in the journal Acta Biomaterialia, the research team demonstrated the ability to recruit stem cells that can form muscle tissue to a small piece of biomaterial, or scaffold that had been implanted in the animals’ leg muscle. The secret to success was using proteins involved in cell communication and muscle formation to mobilize the cells.
“Working to leverage the body’s own regenerative properties, we designed a muscle-specific scaffolding system that can actively participate in functional tissue regeneration,” said Sang Jin Lee, Ph.D., assistant professor of regenerative medicine and senior author. “This is a proof-of-concept study that we hope can one day be applied to human patients.”
The current treatment for restoring function when large segments of muscle are injured or removed during tumor surgery is to surgically move a segment of muscle from one part of the body to another. Of course, this reduces function at the donor site.
Several scientific teams are currently working to engineer replacement muscle in the lab by taking small biopsies of muscle tissue, expanding the cells in the lab, and placing them on scaffolds for later implantation. This approach requires a biopsy and the challenge of standardizing the cells.
“Our aim was to bypass the challenges of both of these techniques and to demonstrate the mobilization of muscle cells to a target-specific site for muscle regeneration,” said Lee.
The Latest on: Muscle regeneration
via Google News
The Latest on: Muscle regeneration
- Astonishing Secret Switch Discovered That Could Revolutionize Heart Attack Treatmenton April 10, 2021 at 12:39 am
Scientists at the Victor Chang Cardiac Research Institute in Sydney have discovered a critical new gene that it is hoped could help human hearts repair damaged heart muscle after a heart attack. Resea ...
- Secrets of Healing the Heart Discovered in Zebrafish Studieson April 9, 2021 at 1:14 pm
This indicates that regeneration after a heart injury is not the same as ... after an event like a heart attack and supercharges the cells to heal damaged heart muscle. It’s an incredible discovery,” ...
- New discovery uncovers secret switch that could revolutionize heart attack treatmenton April 8, 2021 at 11:01 am
Scientists at the Victor Chang Cardiac Research Institute in Sydney have discovered a critical new gene that it is hoped could help human hearts repair damaged heart muscle after a heart attack.
- Angioplasty Gets a Boost from Smart Stents That Heal and Repair Damaged Tissueon April 8, 2021 at 5:00 am
EES also promote muscle regeneration in rats with hind limb ischemia. The researchers plan to test the stent in a large animal model as a step toward clinical trials.
- New discovery uncovers secret switch that could revolutionise heart attack treatmenton April 7, 2021 at 9:00 pm
Researchers have identified a genetic switch in zebrafish that turns on cells allowing them to divide and multiply after a heart attack, resulting in the complete regeneration and healing of damaged ...
- Ask The Dentist: Scientists will soon be able to regenerate teeth in humanson April 7, 2021 at 6:00 pm
This helps teeth function optimally when we chew and allows comfort in our facial muscles and jaw joints ... implement for humans due to high costs and safety factors. The tooth regeneration race is ...
- Boron-loaded hydrogel halves the recovery time for injured muscleson April 1, 2021 at 7:48 am
with the team's technique greatly accelerating their recovery and enabling the muscle to regenerate much more quickly. "We verified that, by adding boron to damaged muscle cells, their level of ...
- A new hydrogel for treatment and recovery of muscle injurieson March 31, 2021 at 11:21 am
A team from the Universitat Politècnica de València (UPV) and the CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) has designed and tested, at a preclinical level, a new biomaterial for ...
- New hydrogel that cuts recovery time in half from muscle injurieson March 31, 2021 at 9:09 am
A team from the Universitat Politècnica de València (UPV) and the CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) has designed and tested, at a preclinical level, a new biomaterial for ...
- New hydrogel that cuts in half recovery time from muscle injurieson March 30, 2021 at 9:00 pm
A team from the (UPV) and the CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) has designed and tested, at a preclinical level, a new biomaterial for the treatment and recovery of ...
via Bing News
