via DARPA
Prototype’s novel approach uses magnetic nano-sized beads to filter deadly microbes and toxins from the bloodstream
Sepsis—a life-threatening over-reaction by the immune system to infection—afflicts 18 million people a year worldwide and kills between 30 and 50 percent of them. Sepsis poses a significant threat to warfighters who suffer combat injuries that predispose them to infection. Antibiotics can kill sepsis-inducing microbes but their overuse is contributing to the threat of drug-resistant microbes and they don’t neutralize the toxins that some pathogens leave behind. Commercial dialysis equipment can remove toxins from the blood but is not built for routine use in theater.
DARPA’s Dialysis-Like Therapeutics (DLT) program seeks to develop integrated, portable and ruggedized technology that would enable widespread deployment of dialysis treatment to fight sepsis. The program recently tested a novel prototype that could greatly advance sepsis treatment and lead to increased survival of future sepsis patients. As reported in Nature Medicine (http://ow.ly/BvJOm), the DLT program successfully demonstrated one of the first technologies for pathogen removal via blood filtration. With a design inspired by the human spleen, the shoebox-sized prototype removes many of the microbes and toxins that can trigger sepsis.
“Sepsis is a massive problem for both civilian and military healthcare, which is why DARPA set out to develop more effective and portable technologies for sepsis treatment,” said U.S.Army Col. Matt Hepburn, DARPA program manager. “Our ‘artificial spleen’ prototype shows a promising new way to fight sepsis more quickly and thoroughly. The technology is also small and light, and usable either on its own or with commercial dialysis equipment.”
Eventually, Hepburn added, DLT could preclude the need to fully identify a bacterium or test whether it is antibiotic resistant—which can take hours or days—before beginning treatment. “We’re hopeful that this new technology could give doctors new tools to save lives in the future,” he said.
The Latest on: Artificial spleen
via Google News
The Latest on: Artificial spleen
- Recent reports of amputations and death highlight rare risk in dog salivaon November 16, 2021 at 11:53 am
It’s a very rare condition that happens most often to people who are asplenic, meaning they don’t have a spleen or their spleen doesn ... in the winter and that led to an infection of the artificial ...
- Epigenetics News and Researchon November 9, 2021 at 3:59 pm
The protein attached to HIVs' genetic material and prevented it from replicating, resulting in reduced levels of HIV in the bone marrow, spleen ... A novel artificial intelligence blood testing ...
- Kronos Bio Reports Recent Business Progress and Third-Quarter Financial Resultson November 9, 2021 at 1:39 pm
Additionally, Kronos Bio yesterday announced a multi-year collaboration with Tempus, a leader in artificial intelligence ... a next-generation spleen tyrosine kinase (SYK) inhibitor.
- Kronos Bio Reports Recent Business Progress and Third-Quarter Financial Resultson November 9, 2021 at 1:11 pm
Additionally, Kronos Bio yesterday announced a multi-year collaboration with Tempus, a leader in artificial intelligence and precision ... a next-generation spleen tyrosine kinase (SYK) inhibitor.
- GeneLab Data Used to Develop Artificial Intelligence Approach for Treating Spaceflight Muscle Disuse Atrophyon November 1, 2021 at 8:05 pm
Transcriptomic datasets from space-flown mice from GeneLab were extensively mined to extract the key genes that cause muscle atrophy in organ muscle tissues such as the thymus, liver, and spleen.
- Recently in the Space Biology Categoryon November 1, 2021 at 3:53 pm
Transcriptomic datasets from space-flown mice from GeneLab were extensively mined to extract the key genes that cause muscle atrophy in organ muscle tissues such as the thymus, liver, and spleen.
- Brave Alloa baby Ollie Mellon battled back from birth with organs out of placeon October 31, 2021 at 10:08 pm
LITTLE Ollie Mellon was saved with a high-tech artificial lung – after his own ... including his liver, spleen and kidneys, being in the wrong place at birth, Miss McGill knows she was right ...
- Rabbit Monoclonal Antibody: a New Diagnostics Technologyon October 28, 2021 at 5:00 pm
Both gene conversion and somatic hypermutation occur in secondary lymphoid tissues such as spleen, lymph nodes, and Peyer’s patches for secondary antibody repertoire diversifying and affinity ...
- HUTCHMED Initiates ESLIM-01, a Phase III Trial of HMPL-523 in Patients with Immune Thrombocytopenia in Chinaon October 27, 2021 at 5:05 pm
About HMPL-523 HMPL-523 is a novel, investigational, selective small molecule inhibitor for oral administration targeting spleen tyrosine kinase, also known as Syk. Syk is a major component in B-cell ...
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