An investigational new heart failure drug could be poised to change the face of cardiology based on Hot Line results presented today at ESC Congress 2014.
Findings from the PARADIGM-HF trial, published simultaneously in the New England Journal of Medicine, “are extraordinarily powerful and compelling; they are destined to change the management of patients with chronic heart failure for years to come,” said Milton Packer, MD, co-primary author of the study from University of Texas Southwestern Medical Center, in Dallas, Texas USA.
“This really is an astonishing result and a real breakthrough for patients with heart failure,” added John McMurray, MD, the other co-primary author, from the University of Glasgow, UK.
The new agent, an angiotensin receptor-neprilysin inhibitor (ARNI) known as LCZ696, has already been granted Fast Track status by the United States Food and Drug Administration (FDA) – a designation which can expedite the review of new medicines intended to treat serious or life-threatening conditions. Fast Track designation also allows for rolling submission in the US, which Novartis said it expects to complete by the end of 2014. The company said it aims to file in Europe in early 2015.
“To say that we are excited is an understatement. We are absolutely thrilled,” said Dr. Packer.
“Given the survival advantage of LCZ696 over currently available drugs, once this drug becomes available, it would be difficult to understand why physicians would continue to use traditional angiotensin converting-enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) for the treatment of heart failure.”
The Latest on: Heart failure
via Google News
The Latest on: Heart failure
- Chemicals produced in the gut after eating red meat may contribute to heart disease riskon August 1, 2022 at 4:34 pm
Chemicals produced by microbes in the digestive tract may be partly responsible for the increased heart disease risk associated with higher consumption of red meats such as beef and pork, a new study ...
- Two heart drugs may increase the risk of heart attack during hot-weather eventson August 1, 2022 at 4:05 pm
For people with coronary heart disease, beta-blockers can improve survival and quality of life, while aspirin and other antiplatelet medications can reduce the risk of a heart attack.
- Heart Disease Will Surge Over the Coming Decadeson August 1, 2022 at 2:04 pm
The prevalence of cardiovascular (CV) risk factors and disease is projected to fall in white individuals by 2060 and increase in all other races and ethnicities. For example, among Black adults, the ...
- Two heart medications tied to greater heart attack risk during very hot weatheron August 1, 2022 at 1:12 pm
For people with coronary heart disease, beta blockers can improve survival and quality of life, while aspirin and other anti-platelet medications can reduce the risk of a heart attack.
- Heart Failure-Related Deaths Up in Younger Adults in the U.S.on August 1, 2022 at 8:52 am
Heart failure-related mortality in young adults increased between 2012 and 2019 in the United States, according to a study published online July 27 ...
- Disparities Seen in LVAD Use for Heart Failure in Seniorson August 1, 2022 at 8:49 am
Disparities in left ventricular assist device (LVAD) use by race and sex exist among Medicare beneficiaries hospitalized for heart failure and are not ...
- Initiative addresses challenges of managing heart failureon August 1, 2022 at 8:46 am
A pilot program at a New York hospital designed to help patients manage heart failure after being discharged from the hospital quickly improved patient adherence to their medication and treatment plan ...
- Red meat consumption can increase the risk of heart disease by altering the gut microbiomeon August 1, 2022 at 8:07 am
The finding has uncovered a new target for possible treatments to combat heart disease. New research in the US suggests the consumption of red meat may be a primary driver of atherosclerotic ...
- This Bay Area doctor reversed heart disease. Now he wants to do it for Alzheimer’son August 1, 2022 at 6:27 am
At his nonprofit Preventive Medicine Research Institute in California, he’s using the same four lifestyle interventions to see if early-stage Alzheimer’s can be “slowed, stopped or even reversed” ...
- Cardiomyopathy is scary. But today, the heart disease is less deadly.on August 1, 2022 at 4:17 am
Cardiomyopathy results from a weakening of the heart muscle that causes the heart to beat less vigorously. As the heart loses strength, it often enlarges to compensate for its lac ...
via Bing News