Nobel laureate K. Barry Sharpless at The Scripps Research Institute (TSRI)
The findings open a doorway on an unexplored chemical galaxy containing vast numbers of new molecules for making drugs, plastics and unprecedented smart materials
Chemists led by Nobel laureate K. Barry Sharpless at The Scripps Research Institute (TSRI) have used his click chemistry to uncover unprecedented, powerful reactivity for making new drugs, diagnostics, plastics, smart materials and many other products.
The new SuFEx—Sulfur Fluoride Exchange—reactions enable chemists to link molecules of their choice together using derivatives of a common commercial chemical considered essentially inert. The Sharpless team made this chemical reliably and predictably reactive. Astonishingly, acid-base constraints are rarely a concern, though they are central to nature’s chemistry and an enormous hurdle for chemists. The stabile linkers are also non-polar and can enter cells, so have potential for crossing the blood-brain barrier.
Consequently, SuFEx gives easy access to an entire, unexplored galaxy within the chemical universe.
“This is a new, emergent phenomenon,” said Sharpless, the W.M. Keck Professor of Chemistry and member of the Skaggs Institute for Chemical Biology at TSRI.
Click chemistry, conceived in the mid-90s as a method for discovering new and improving existing chemical reactivity, became universally used in the chemical sciences after the 2002 discovery of copper-catalyzed azide-alkyne cycloaddition (CuAAC). Now SuFEx is the second “perfect” click reaction to be discovered at TSRI.
The Latest on: Click Chemistry
via Google News
The Latest on: Click Chemistry
- Bae took these - Sister Derby says as she drops beautiful photos after finding loveon January 18, 2022 at 1:56 pm
Multiple award-winning Ghanaian musician Deborah Vanessa Owusu-Bonsu famed as Sister Derby, has been spotted having fun with her handsome boyfriend, David.
- Andrew Wiggins gets real on Warriors’ chemistry with Klay Thompson backon January 18, 2022 at 1:53 pm
Tuesday night, the Golden State Warriors will host their second home game with Klay Thompson in the lineup. Since his return, the Warriors have won just one out of four games he has appeared in this ...
- Automated fast-flow instrument that can synthesize peptide-nucleic acids in a single shoton January 12, 2022 at 6:20 am
Researchers in the lab of Bradley Pentelute, MIT professor of chemistry, have invented a fully automated fast-flow instrument that can synthesize peptide-nucleic acids in a single shot.
- Synthesis too slow? Let this robot do it.on January 11, 2022 at 2:10 pm
MIT researchers invented a fully automated fast-flow instrument called Tiny Tides that can synthesize cell-penetrating peptide-conjugated peptide nucleic acids (PPNAs) in a single shot, significantly ...
- Shasqi to Present at the 40th Annual J.P. Morgan Healthcare Conferenceon January 7, 2022 at 5:32 am
Mejía Oneto, M.D., Ph.D., will present at the 40th Annual J.P. Morgan Healthcare Conference on Monday, January 10, 2022, at 10 a.m. EST. Dr. Mejía Oneto will provide an overview of Shasqi, recent ...
- From click chemistry to antibiotic spider silkon January 3, 2022 at 4:00 pm
Antimicrobial activity can be maintained for at least five days. The Nottingham research team has shown for the first time how so-called click chemistry can be used to attach molecules, such as ...
- It takes two: The future of click chemistry therapeuticson December 23, 2021 at 5:16 pm
Twenty years ago ‘click chemistry’, a simple yet powerful concept to tackle this challenge, was first coined by Hartmuth Kolb, M.G. Finn and Nobel prize winner Barry Sharpless. The term ...
- Click Chemistry Lab (IMAGE)on December 6, 2021 at 8:00 am
Moses’ group at Cold Spring Harbor Laboratory, seen drawing out a “click” chemistry reaction. Click reactions allow chemists to assemble molecules quickly, reliably, and cleanly.
- Winner: 2021 Organic Division Horizon Prize:on June 8, 2021 at 2:50 am
A multidisciplinary collaboration has opened up a huge number of possibilities in synthetic chemistry through developing the technique of multidimensional click chemistry. Click chemistry is a method ...
- Boronic Acid Functionalized Magnetic Nanoparticles via Thiol-ene Click Chemistry for Selective Enrichment of Glycoproteinson March 31, 2021 at 3:59 pm
A simple, novel approach was developed for the preparation of boronic acid functionalized Fe3O4 magnetic nanoparticles (MNPs) via thiol-ene (TE) click reaction. In this work, two clickable Fe3O4 MNPs ...
via Bing News
