A new study from the Gladstone Institutes has revealed a way to alleviate the learning and memory deficits caused by apoE4, the most important genetic risk factor for Alzheimer’s disease, improving cognition to normal levels in aged mice.
In the study, which was conducted in collaboration with researchers at UC San Francisco and published today in the Journal of Neuroscience, scientists transplanted inhibitory neuron progenitors—early-stage brain cells that have the capacity to develop into mature inhibitory neurons—into two mouse models of Alzheimer’s disease, apoE4 or apoE4 with accumulation of amyloid beta, another major contributor to Alzheimer’s. The transplants helped to replenish the brain by replacing cells lost due to apoE4, regulating brain activity and improving learning and memory abilities.
“This is the first time transplantation of inhibitory neuron progenitors has been used in aged Alzheimer’s disease models,” said first author Leslie Tong, a graduate student at the Gladstone Institutes and UCSF. “Working with older animals can be challenging from a technical standpoint, and it was amazing to see that the cells not only survived but affected activity and behavior.”
The success of the treatment in older mice, which corresponded to late adulthood in humans, is particularly important, as this would be the age that would be targeted were this method ever to be used therapeutically in people.
The Latest on: Reversing memory loss
[google_news title=”” keyword=”Reversing memory loss” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Reversing memory loss
- If you experience brain fog, memory loss during long flights, here’s what you should doon February 6, 2023 at 12:19 pm
Your brain is 73 per cent water and only two per cent of dehydration in your brain can lead to memory loss and decline in your cognitive function,” she explained. Thus, you must never undermine the ...
- Brain health – Preventing and coping with memory losson January 31, 2023 at 2:25 am
If “forgetfulness” starts to impact on day-to-day living, then it is significant memory loss and medical attention needs to be sought from a specialist/ geriatrician as soon as possible. The good news ...
- An action plan to prevent Alzheimer's diseaseon January 30, 2023 at 4:00 pm
Memory loss, behavioural changes, cognitive deficits: Alzheimer's disease leads to a dramatic loss of autonomy for those affected and has a heavy impact on health costs. Its prevention has become ...
- Memory loss could be a warning sign of high cholesterol - and 4 ways to reduce riskon January 30, 2023 at 4:40 am
Dr Joseph Ambani from GlowBar claims memory loss is an unusual symptom of too much cholesterol. “High cholesterol is a common condition that can have a variety of symptoms,” he explained.
- Suffering with memory loss? It could be a sign your cholesterol is too highon January 28, 2023 at 3:14 am
One such sign, he said, is memory loss. “High cholesterol is a common condition that can have a variety of symptoms,” he told Express.co.uk. READ MORE: Dr Mosley shares 'gentle' movement to ...
- Memory Loss After a Traumatic Brain Injury (TBI) and How to Improve It by David Priede, PhDon January 22, 2023 at 4:00 pm
In summary, memory loss is a common and potentially severe consequence of traumatic brain injury (TBI). Early diagnosis and treatment, including rehabilitation, can help to minimize the effects of ...
- Memory loss: When to seek helpon January 20, 2023 at 5:45 am
There's a difference, however, between normal changes in memory and memory loss associated with Alzheimer's disease and related disorders. And some memory problems are the result of treatable ...
- Memory Loss: Treatment, Cost and Side Effectson January 19, 2023 at 4:00 pm
Memory loss is the condition where a patient is unable to recall the long term, short term, or both types of memories. It may be mild as occasionally forgetting names or misplacing small things, or ...
- Common Asthma Drug may Help Reverse Memory Losson January 13, 2023 at 7:48 am
Amnesia, is profound memory loss caused by a physical injury inflicted on the brain, by an infection or by a ... Drug toxicity is an adverse reaction of the body towards a drug that results as a ...
- Definition of 'memory loss'on January 9, 2023 at 4:01 pm
There are no drugs to reverse memory loss. They hope to discover why certain people suffer from memory loss. As many as half of such patients suffer minor brain damage such as memory loss. There is ...
via Bing News
