A new study from the Gladstone Institutes has revealed a way to alleviate the learning and memory deficits caused by apoE4, the most important genetic risk factor for Alzheimer’s disease, improving cognition to normal levels in aged mice.
In the study, which was conducted in collaboration with researchers at UC San Francisco and published today in the Journal of Neuroscience, scientists transplanted inhibitory neuron progenitors—early-stage brain cells that have the capacity to develop into mature inhibitory neurons—into two mouse models of Alzheimer’s disease, apoE4 or apoE4 with accumulation of amyloid beta, another major contributor to Alzheimer’s. The transplants helped to replenish the brain by replacing cells lost due to apoE4, regulating brain activity and improving learning and memory abilities.
“This is the first time transplantation of inhibitory neuron progenitors has been used in aged Alzheimer’s disease models,” said first author Leslie Tong, a graduate student at the Gladstone Institutes and UCSF. “Working with older animals can be challenging from a technical standpoint, and it was amazing to see that the cells not only survived but affected activity and behavior.”
The success of the treatment in older mice, which corresponded to late adulthood in humans, is particularly important, as this would be the age that would be targeted were this method ever to be used therapeutically in people.
The Latest on: Reversing memory loss
[google_news title=”” keyword=”Reversing memory loss” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Reversing memory loss
- Virginia Tech electrical engineer works to reverse memory loss in Alzheimer’s diseaseon November 29, 2023 at 10:03 am
A Virginia Tech electrical engineer is partnering with neuroscience professionals in creating a new device to slow or reverse the spread of memory loss in those with Alzheimer's disease.
- Killing 'Zombie' Cells Emerges As Key to Reversing Covid-Induced Brain Agingon November 24, 2023 at 9:08 am
Researchers have found a way to reverse a cellular process triggered by Covid that contributes to premature aging of the brain.
- Neuroscientists Kill 'Zombie' Cells to Reverse COVID Brain Agingon November 23, 2023 at 6:27 am
Infection with SARS-CoV-2 accelerates the rate of premature aging in the brain. But what if there was a way to turn back the clock?
- Researchers discover way to reverse brain aging caused by COVID-19on November 22, 2023 at 4:29 am
University of Queensland researchers have found a way to reverse a cellular process triggered by COVID-19 that contributes to premature aging of the brain.
- Reversing ‘zombie’ brain fog and memory loss after Covid-19 infection, scientists revealon November 21, 2023 at 4:17 pm
Scientists have uncovered how to reverse the ageing effects of ‘zombie’ cells.
- Definizione di memory losson November 20, 2023 at 4:00 pm
There are no drugs to reverse memory loss. They hope to discover why certain people suffer from memory loss. As many as half of such patients suffer minor brain damage such as memory loss. There is ...
- The Alzheimer's Solution: A revolutionary guide to how you can prevent and reverse memory loss - Softcoveron November 13, 2023 at 1:18 pm
Based on the largest clinical and observational study to date,The Alzheimer's Solution, by leading neurologists and Alzheimer's specialists Drs Dean and Ayesha Sherzai, provides the essential ...
- A jab to boost memoryon November 4, 2023 at 5:00 pm
A simple injection could reverse memory loss and brain deterioration caused by ageing, scientists claim. They have carried out tests of a new technique to replace and repair lost brain cells.
via Bing News
