Currently, no cure exists for Alzheimer’s disease, the devastating neurological disease affecting more than 5 million Americans.
But scientists are now reporting new progress on a set of compounds, initially developed for cancer treatment, that shows promise as a potential oral therapy for Alzheimer’s. Their study appears in ACS’ Journal of Medicinal Chemistry.
Carlo Ballatore, Kurt R. Brunden and colleagues explain that in a healthy brain, the protein known as tau binds to and stabilizes microtubules, which are cellular components made of protein inside cells. Microtubules are critical for performing many processes in the cell, such as growth and division. In the brain, they are particularly important for transporting molecules or other “cargo,” such as nutrients. But in people with Alzheimer’s disease, tau doesn’t bind well to microtubules and clumps up in the brain. That leaves microtubules in disarray. Scientists believe that this process leads to the mental problems associated with the disease, including memory loss, dementia and ultimately nerve cell death. The researchers have previously shown that when agents that can stabilize microtubules are given to mice with Alzheimer-like traits, their cognition has improved, and nerve cell loss is reduced. But the experimental compounds so far have not been good drug candidates mainly because they must be injected, which can be painful. The Ballatore and Brunden teams wanted to test a series of compounds, already identified as potential anti-fungal and anti-cancer agents, that patients might one day be able to take orally.
They gave the compounds to mice by mouth and found that the drugs reached the brain, took on the role of tau and stabilized microtubules in the animals’ brains. This led the scientists to conclude that the molecules from these classes could be good oral therapy candidates for treating Alzheimer’s and related disorders.
The Latest on: Alzheimer’s
via Google News
The Latest on: Alzheimer’s
- Alzheimer's disease: Five things to knowon September 24, 2022 at 5:19 am
Alzheimer's disease affects more than 30 million people worldwide and remains an illness for which there is no cure.
- Walk to fight Alzheimer’s today in St. Charleson September 24, 2022 at 4:36 am
Alzheimer’s disease can rob a person of their memories, their physical independence, and eventually their lives.
- Alzheimer's disease diagnosis based on fabricated data — here's what it meanson September 24, 2022 at 4:00 am
The pursuit of a cure for Alzheimer’s disease is becoming an increasingly competitive and contentious quest with recent years witnessing several important controversies.
- News Briefs: Alzheimer's Association plans educational programson September 24, 2022 at 2:31 am
The Alzheimer's Association Northwest Ohio Chapter is hosting two in-person educational programs in Napoleon and Fremont that will offer ways to connect and communicate at each stage of dementia. The ...
- Watch out, Alzheimer’s! Big new grant at UCI, new drug trial at Hoag coming for youon September 24, 2022 at 12:37 am
We remain in our infancy in our field compared to other fields of medicine, but we’re learning at an incredible rate.’ ...
- Early, Midlife Infections Up Alzheimer's, Parkinson's Riskon September 23, 2022 at 11:40 am
Early and midlife infections treated in outpatient or inpatient hospital settings upped the risk of a subsequent Alzheimer's or Parkinson's disease diagnosis, a case-control study in Sweden showed. A ...
- Milwaukee exhibit addresses Alzheimer's, a growing problem within Latino communityon September 23, 2022 at 10:23 am
This is the story behind a new exhibit that addresses a growing problem within the Latino community through an artistic lens and a family finding hope through illness.
- Columbus Walk to End Alzheimer's raises awareness, celebrates communityon September 23, 2022 at 3:06 am
That day eight years ago brought about two significant events in the life of the Hilliard resident: Her youngest granddaughter was born and her mother died from Alzheimer's disease at the age of 95.
- Minipigs Carrying Gene Mutation Associated With Alzheimer’s Provide New Research Toolon September 23, 2022 at 12:47 am
Minipigs with a mutation to the SORL1 gene that is associated with Alzheimer's could provide new research insights into treatments for the disease that are effective in the early stages.
- Can We Beat Alzheimer’s? Biogen and Eisai’s Latest Drug Trial Will Offer Clues.on September 22, 2022 at 11:46 am
The company’s last attempt to target the devastating disease flopped. Results from a key trial of Biogen and Eisai’s new drug, lecanemab, are coming soon—and have huge implications.
via Bing News