Sean Davies, Ph.D., center, Zhongyi Chen, M.D., Ph.D., left, and Lilu Guo, Ph.D., are studying using bacteria as a therapeutic compound in the gut to counteract the effects of a high-fat diet. (photo by Joe Howell)
A probiotic that prevents obesity could be on the horizon.
Bacteria that produce a therapeutic compound in the gut inhibit weight gain, insulin resistance and other adverse effects of a high-fat diet in mice, Vanderbilt University investigators have discovered.
“Of course it’s hard to speculate from mouse to human,” said senior investigator Sean Davies, Ph.D., assistant professor of Pharmacology. “But essentially, we’ve prevented most of the negative consequences of obesity in mice, even though they’re eating a high-fat diet.”
Regulatory issues must be addressed before moving to human studies, Davies said, but the findings published in the August issue of the Journal of Clinical Investigation suggest that it may be possible to manipulate the bacterial residents of the gut – the gut microbiota — to treat obesity and other chronic diseases.
Read more . . .
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