Treatment reverses symptoms of type 2 diabetes in mice without side effects.
In mice with diet-induced diabetes—the equivalent of type 2 diabetes in humans—a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days.
The discovery by Salk scientists, published today in the journal Nature, could lead to a new generation of safer, more effective diabetes drugs.
The team found that sustained treatment with the protein doesn’t merely keep blood sugar under control, but also reverses insulin insensitivity, the underlying physiological cause of diabetes. Equally exciting, the newly developed treatment doesn’t result in side effects common to most current diabetes treatments.
“Controlling glucose is a dominant problem in our society,” says Ronald M. Evans, director of Salk’s Gene Expression Laboratory and corresponding author of the paper. “And FGF1 offers a new method to control glucose in a powerful and unexpected way.”
The Latest on: FGF1
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The Latest on: FGF1
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Usually, the eye initiates a healing response when cells come into contact with Fibroblast Growth Factor 1 (FGF1), a key catalyst for cell division in the cornea. FGF1's primary role is to ...
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FGF1, FGF2 and FGF4 have been studied in clinical trials for the treatment of cardiovascular disease. The results of most of these trials have been unclear. However, some promising prospects remain.
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Bradshaw and Thomas first identified acidic FGF (FGF1) and Bradshaw and the other co-founders, all of whom were his postdocs or doctoral students, continued to advance the field. The technology ...
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