NIH trial success suggests a new treatment option for older, sicker patients
Adults stop anti-rejection drugs after stem-cell transplant reverses sickle cell disease NIH trial success suggests a new treatment option for older, sicker patients
Half of patients in a trial have safely stopped immunosuppressant medication following a modified blood stem-cell transplant for severe sickle cell disease, according to a study in the July 1 issue of the Journal of the American Medical Association. The trial was conducted at the National Institutes of Health‘s Clinical Center in Bethesda, Maryland, by researchers from NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Heart, Lung, and Blood Institute.
The transplant done in the study reversed sickle cell disease in nearly all the patients. Despite having both donor stem-cells and their own cells in their blood, the patients stopped the immunosuppressant medication without experiencing rejection or graft-versus-host disease, in which donor cells attack the recipient. Both are common, serious side effects of transplants.
“Typically, stem-cell recipients must take immunosuppressants all their lives,” said Matthew Hsieh, M.D., lead author on the paper and staff clinician at NIH. “That the patients who discontinued this medication were able to do so safely points to the stability of the partial transplant regimen.”
The Latest on: Sickle cell disease
via Google News
The Latest on: Sickle cell disease
- Sickle Cell Advocacy Group Hosting "Conversations"on August 20, 2021 at 7:44 am
The Sickle Cell Consortium, a U.S.-based non-profit organized to ensure sickle cell patients and caregivers are at the center of disease education, research, legislation, and policy, announced today ...
- Networking California for Sickle Cell Care celebra su reunión inauguralon August 18, 2021 at 3:39 pm
SACRAMENTO, California, 18 de agosto de 2021 /PRNewswire-HISPANIC PR WIRE/ -- El día de hoy, Networking California for Sickle Cell Care celebró su reunión inaugural, la primera vez que los ...
- 8-year-old named ambassador hospital after beating back blood disease and rare brain syndromeon August 18, 2021 at 12:08 pm
Camryn Kellam was living with sickle cell blood disease and Moyamoya disease a t8 years old. VALHALLA, New York (WCBS) -- Being an ambassador is a big job for a young girl. But has proved that she’s ...
- Trial study at Children's Hospital Colorado is curing teens of sickle cell diseaseon August 18, 2021 at 6:47 am
About 100,000 people in the United States have sickle cell disease, but a medical breakthrough is happening at Children's Hospital Colorado.
- Sickle cell trait: an unsound cause of deathon August 17, 2021 at 5:05 pm
In forensic pathology, cause of death is defined as the disease or injury that triggers the events that lead to death. If a chronically ill woman dies from a gunshot wound, it is this injury, not her ...
- 8-Year-Old Named Ambassador At Maria Fareri Children’s Hospital After Beating Back Blood Disease And Rare Brain Syndromeon August 17, 2021 at 4:35 pm
Being an ambassador is a big job for a young girl. But 8-year-old Camryn Kellam has proved that she's pretty much up to any challenge.
- Networking California for Sickle Cell Care Holds Inaugural Meetingon August 17, 2021 at 1:00 pm
Today Networking California for Sickle Cell Care held its inaugural meeting, marking the first time that clinicians from the ten participating Network clinics ...
- ASH Research Collaborative Announces First Ten Clinical Trial Consortia to Join the Sickle Cell Disease Clinical Trials Networkon August 16, 2021 at 7:41 am
The ASH Research Collaborative (ASH RC) has announced the first 10 clinical research consortia to join the ASH RC Sickle Cell Disease Clinical Trials Network. The sites will be able to enroll children ...
- Kenya Targets Easing Sickle Cell Disease Pain Through Quality and Affordable Careon August 13, 2021 at 3:41 am
Health experts in Kenya aim to reduce the number of children born with sickle cell disease -- an inherited blood disorder -- by more than 12 times through public education and awareness, as the ...
- Unmasking sickle cellon August 12, 2021 at 10:10 pm
From malaria treatment to bitter herbs, people with sickle cell are not having it easy when seeking treatment. A study done at Queen Elizabeth Central Hospital in 2011 among children aged between ...
via Bing News