Research explains action of drug that may slow aging and related disease

The target is an enzyme called mTOR, which regulates metabolism. Drugs that block this enzyme—such as rapamycin—allow mice and other animals to live longer. “Rapamycin always expands life ...

Being diagnosed with type 1 diabetes today means a lifetime of insulin injections – as of yet, we don't have a simple one-time fix on hand.

The first of its three phases looked into the anti-rejection medicine rapamycin, and whether or not it could help in extending the lives of dogs. The drug is already used in humans to aid their ...

The Dog Aging Project's first of three phases aimed to discover whether the anti-rejection medicine rapamycin could help extend dogs' lives. Sign up to our TeamDogs newsletter for your weekly dose ...

A new research perspective published in Oncoscience by Mikhail Blagosklonny, M.D., Ph.D., looks at the possibility of immediate life extension using rapamycin. "Here I discuss how combining ...

“Here I discuss how combining rapamycin with other modalities may let us live long enough to benefit from future discoveries in cellular reprogramming and what needs to be done at Altos Labs to ...

After the cultures were established, we stimulated the cells with TGF−β (5 ng/ml), pirfenidone (1 mg/ml) and rapamycin (1 μg/ml). Besides the treatment of rapamycin and pirfenidone without TGF ...

Pirfenidone is currently one of the primary choices for the treatment of IPF in clinical practice, however, it does not stop or cure the disease completely, suggesting that a combination with ...

San Antonio — Executives at Rapamycin Holdings believe a decades-old drug used to prevent organ transplant rejection could find a new use as a treatment for prostate cancer, and hope to begin ...

The antitumour drug rapamycin targets TOR, a kinase that is part of the PI3K–AKT–mTOR cascade, involved in regulating protein translation, cell growth and autophagy. Reducing TOR function is known to ...